Navigation Links
Groovy protein essential for promoting cancer development

Scientists have determined the detailed structure of an essential piece of the telomerase enzyme, an important contributor to the vast majority of human cancers. Understanding the physical shape of the protein has led to a better understanding of how it acts to immortalize cells ?and should help scientists design broadly effective cancer drugs.

Until now, the lack of detailed structural information about the enzyme has hindered progress in developing agents to inhibit it, say the researchers, who published their findings in an advance online publication in Nature Structural & Molecular Biology on February 5, 2006. Howard Hughes Medical Institute President Thomas R. Cech, whose laboratory is at the University of Colorado at Boulder, led the study, conducted with colleagues Steven A. Jacobs and Elaine R. Podell.

Cancer researchers have long sought a way to subdue telomerase, an enzyme whose excessive activity contributes to the unchecked growth of as many as 90 percent of human tumors. The enzyme is vital for some rapidly dividing cells ?such as those in a developing embryo ? where it extends telomeres, the regions of highly repetitive DNA found at the ends of chromosomes. In most healthy adult cells, telomerase is shut off, and telomeres slowly shrink during cell division ?a normal process that helps limit cells' lifespan. Cancer cells, however, usually find a way to turn telomerase back on, achieving a dangerous immortality.

"Getting telomeres replicated again is required for carcinogenesis to proceed," Cech explained. "It's an essential step in the development of cancer, and that makes it of a lot of interest therapeutically, because it is a target that could impact a wide variety of cancers."

Telomerase inhibitors have been in clinical development for many years, but, Cech said, progress has been slow. "The development of anti-telomerase chemotherapeutics has been challenged by the fact that there was no structural basi
'"/>

Source:Howard Hughes Medical Institute


Page: 1 2 3 4

Related biology news :

1. New, automated tool successfully classifies and relates proteins in unprecedented way
2. New binding target for oncogenic viral protein
3. Controversial drug shown to act on brain protein to cut alcohol use
4. Timing is everything: First step in protein building revealed
5. UWs Rosetta software to unlock secrets of many human proteins
6. Researchers find how protein allows insects to detect and respond to pheromones
7. Signaling protein builds bigger, better bones in mice
8. Ancient olfaction protein is shared by many bugs, offering new pest control target
9. Automatic extraction of gene/protein biological functions from biomedical text
10. Discovery of key proteins shape could lead to improved bacterial pneumonia vaccine
11. Scientists develop new color-coded test for protein folding
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Groovy protein essential for promoting cancer development

(Date:10/17/2014)... To date, antidotes ... doctors are often limited to supportive therapy such as induced ... of drugs involved. So what can be done if a ... professor Jean-Christophe Leroux from the Institute of Pharmaceutical Sciences at ... "The task was to develop an agent that could eliminate ...
(Date:10/16/2014)... Mary,s Virginia Institute of Marine Science have received ... Agency to identify the streams and wetlands most ... to help local governments and citizens conserve these ... a dataset of tidal-marsh observations first gathered by ... historical baseline can today,s researchers accurately map the ...
(Date:10/16/2014)... challenged conventional thinking on how the bowel lining develops ... how bowel cancer starts. , The researchers produced evidence ... the ,crypts, that are a feature of the bowel ... bowel cancer development, a controversial finding as scientists are ... 3D imaging technologies, Dr Chin Wee Tan and Professor ...
Breaking Biology News(10 mins):Emergency aid for overdoses 2Emergency aid for overdoses 3EPA grant will help localities conserve headwater wetlands 2EPA grant will help localities conserve headwater wetlands 3Cryptic clues drive new theory of bowel cancer development 2
... experiences trauma or disease, such as muscular dystrophy, ... cells" respond to repair and regenerate the muscle. ... such as muscular dystrophy, which affect muscle stability ... used time-lapse photography to document satellite cell movements ...
... PHILADELPHIA Although acute myeloid leukemia (AML) is relatively ... the risk, according to a recent paper published in ... of the American Association for Cancer Research. Julie ... and clinical research at the University of Minnesota, said ...
... to the poles, and you,ll notice that the ... equator. Move from lowland to mountains, and you,ll ... varied. Ecologists have proposed various explanations for these ... processes. New findings by University of ...
Cached Biology News:Caught on tape: Muscle stem cells captured on video by MU researcher 2Climate change and mountain building led to mammal diversity patterns 2
(Date:10/25/2014)... October 24, 2014 This research ... PBS, Starch Based Plastics, Regenerated Cellulose, PCL), by ... Trends and Forecasts to 2019”, defines and segments ... and forecast of its global volume and value. ... Figures spread through 178 Slides and in-depth TOC ...
(Date:10/25/2014)... (PRWEB) October 24, 2014 A new ... overcome several pitfalls of current skin grafting technologies, it ... produces hair. The method, outlined in the October issue ... for treating deep skin injuries that result from severe ... completely destroys the skin’s regenerative elements. These wounds heal ...
(Date:10/25/2014)... NEW YORK , Oct. 24, ... formerly Access Pharmaceuticals, Inc. (ACCP), a biopharmaceutical company ... has implemented a 1-for-50 reverse split of its ... on Friday, October 24, 2014. PlasmaTech,s common stock ... CUSIP number 72754H109 and temporary ticker symbol "ACCPD". ...
(Date:10/25/2014)... 2014 Research and Markets has ... Product , Research Area & by End User - ... In this report, the global epigenetics ... areas, and end users. The product segments of the ... & consumables, kits, and reagents. The subsegments of the ...
Breaking Biology Technology:Biodegradable Plastics Market Projected to $3,476.87 Million by 2019 - Report by MarketsandMarkets 2Biodegradable Plastics Market Projected to $3,476.87 Million by 2019 - Report by MarketsandMarkets 3Biodegradable Plastics Market Projected to $3,476.87 Million by 2019 - Report by MarketsandMarkets 4New engineering method shows promise for faster healing, more cosmetically appealing skin grafts 2New engineering method shows promise for faster healing, more cosmetically appealing skin grafts 3PlasmaTech Biopharmaceuticals, Inc. Announces Reverse Stock Split, Ticker Change and Launches New Corporate Website 2Global Epigenetics (VLA, WBA, NBA, RTA, Rotary-Wing Aircraft) Market - Forecast to 2019 2Global Epigenetics (VLA, WBA, NBA, RTA, Rotary-Wing Aircraft) Market - Forecast to 2019 3
... in a hexagonal, chicken wire structure holds great ... conductive, graphene may one day replace conventional silicon microchips, ... In addition to potential applications in integrated circuits, solar ... material has attracted the attention of physicists for its ...
... Inc. (NYSE Amex: NBS ), an international biopharmaceutical company ... will present on a panel at the 31st Annual Cowen Group ... March 7, 2011 at 1 PM and Dr. Robin Smith, the ... at 10:15 AM. The Conference will be held at the Boston ...
... Corporation (Nasdaq: VOLC ), a leading developer ... enhance the diagnosis and treatment of coronary and peripheral ... market the Eagle Eye® Platinum digital IVUS catheter in ... PCI Live Demonstration Course in Kurashiki, which starts on ...
Cached Biology Technology:Probing atomic chicken wire 2Probing atomic chicken wire 3Probing atomic chicken wire 4NeoStem to Present at Cowen Group 31st Annual Health Care Conference on March 7 and 8 2NeoStem to Present at Cowen Group 31st Annual Health Care Conference on March 7 and 8 3Volcano Announces the Introduction of the Eagle Eye® Platinum Digital IVUS Catheter at the 20th PCI Live Demonstration Course in Kurashiki 2Volcano Announces the Introduction of the Eagle Eye® Platinum Digital IVUS Catheter at the 20th PCI Live Demonstration Course in Kurashiki 3
Recommended for supporting the growth of anchorage-dependent cells including human and mouse stromal cells, mesenchymal cells and cell lines....
... number is a new product ... Cornings product number. If showing ... under the old Sigma-Aldrich number ... for assistance. ID clarifier: cap, ...
Extremely high efficiency packaging extracts useful for transfecting our EpiFOS™ or CopyControl™ Fosmids, or any DNA vector with cos sites. A tremendous value when conpared to the competition...
... General description: Workstation for PCR set-up ... 96 MicroWell format to hold 0.2 ml PCR tubes, ... compatible with automated handling systems Removable tray ... Compatible with V-bottom 0.2 ml tube block thermal ...
Biology Products: