Navigation Links
Grand Challenges in Global Health initiative funds Yale project

Yale has been offered $17 million from the Grand Challenges in Global health initiative to genetically engineer mice with immune systems similar enough to humans to aid in testing the safety and effectiveness of potential vaccines.

Funded by the Bill & Melinda Gates Foundation, the Yale project will be headed by Richard A. Flavell, M.D., Sterling Professor and Chair of Immunobiology at Yale University School of Medicine, and Howard Hughes Medical Institute investigator.

Flavell and his team will study a novel solution to a problem facing many vaccine developers. Some of the most promising vaccines for HIV and a range of other diseases are made from weakened versions of the infectious agent. These cannot be studied in human trials unless researchers are confident that they are safe.

"A big need in the world of vaccine development is the ability to predict whether vaccines for humans are safe and effective," said Flavell. "We are grateful to the Grand Challenges in Global Health Initiative for providing the funds to develop a predictive model system for vaccine testing."

Yale School of Medicine Dean Robert Alpern, M.D., said, "This generous grant from the Grand Challenges in Global Health Initiative provides a boost to Yale's ongoing initiatives in basic science and clinical research. It will advance research on diseases that have an effect on communities worldwide."

The goal of this award is to provide to the research community a suitable model system to test live attenuated vaccines for use in the developing world. Flavell said the mice generated would be made available to the broader scientific community in order to meet the charitable objectives of the Grand Challenges Initiative. Flavell will collaborate with the Institute for Research in Biomedicine in Switzerland and with Regeneron Pharmaceuticals in Tarrytown, New York.

The team will engineer a mouse model in which critical components of the human immune syste m replace the similar regions of the mouse. A new technology developed at the Institute for Research in Biomedicine introduces cells from human umbilical cord blood into mice to establish a human immune system. "Using this technology and the genetic modification of the mouse, we will end up with a reasonably faithful replica of the human immune system," said Flavell.

The project is titled "A Mouse Model to Evaluate Live-Attenuated Vaccine Candidates."


Source:Yale University

Related biology news :

1. Measurement Challenges In Detecting Cancer Biomarkers
2. Global analysis of membrane proteins
3. Global warming increases oyster sensitivity to pollution
4. Global study shows all tobacco bad for the heart
5. Global warming may warrant new approaches to ecosystem restoration
6. Global warming may have damaged coral reefs forever
7. Global malaria map key weapon in fight against malaria, scientists say
8. Global changes alter the timing of plant growth, scientists say
9. Global map shows new patterns of extinction risk
10. Global sunscreen has likely thinned, report NASA scientists
11. Global survey of lizards reveals greater abundance of animals on islands than on mainland ecosystems
Post Your Comments:

(Date:9/28/2015)... , Sept. 28, 2015 CLEAR, ... that its expedited traveler service is coming ... transforms travel, bringing a frictionless experience, serious ... "CLEAR offers our travelers an ... service," said Jim Smith , Executive ...
(Date:9/28/2015)... 28, 2015 The global ... USD 12.03 billion by 2020, growing at a CAGR ... as Backside Illumination (BSI) technique to improve picture quality ... period.      (Logo: , ... to reduce loss and, thus, reduce the noise interference ...
(Date:9/28/2015)... SAN JOSE, Calif. , Sept. 28, 2015 /PRNewswire/ ... developer of human interface solutions, today announced that Lenovo ... area touch fingerprint sensor, FS4202, for its latest smartphone, ... enables secure, password-free access to unlock the device and ... consumers. The feature-rich Natural ID FS4202 ...
Breaking Biology News(10 mins):
(Date:10/13/2015)... Calif. , Oct. 13, 2015  Cepheid (Nasdaq: ... quarter ending September 30, 2015. --> ... results, total revenue for the third quarter of 2015 ... loss per share is expected to be approximately $(0.32) ... results, non-GAAP net loss per share for the third ...
(Date:10/13/2015)... Research and Markets( ) has announced ... for Bone Morphogenetic Protein Growth Factor Therapy - 16 ... --> --> Bone morphogenetic proteins ... bone after a fracture. In nature, these proteins have ... of the skeleton. There are twenty different BMPs that ...
(Date:10/13/2015)... ... October 13, 2015 , ... AxioMx Inc. ... it has received a Phase I Small Business Innovative Research (SBIR) grant (1R43GM112204-01A1). ... General Medical Sciences (NIGMS), will fund the development of a technique to rapidly ...
(Date:10/13/2015)... 13, 2015  According to Kalorama Information, the ... $102 billion by the end of 2015. Clinical ... industry, as it is estimated that approximately 80% ... tests. In addition to diagnosing patients, clinical lab ... progression, monitor drug treatment and conditions, and determine ...
Breaking Biology Technology: