Navigation Links
Grand Challenges in Global Health initiative funds Yale project

Yale has been offered $17 million from the Grand Challenges in Global health initiative to genetically engineer mice with immune systems similar enough to humans to aid in testing the safety and effectiveness of potential vaccines.

Funded by the Bill & Melinda Gates Foundation, the Yale project will be headed by Richard A. Flavell, M.D., Sterling Professor and Chair of Immunobiology at Yale University School of Medicine, and Howard Hughes Medical Institute investigator.

Flavell and his team will study a novel solution to a problem facing many vaccine developers. Some of the most promising vaccines for HIV and a range of other diseases are made from weakened versions of the infectious agent. These cannot be studied in human trials unless researchers are confident that they are safe.

"A big need in the world of vaccine development is the ability to predict whether vaccines for humans are safe and effective," said Flavell. "We are grateful to the Grand Challenges in Global Health Initiative for providing the funds to develop a predictive model system for vaccine testing."

Yale School of Medicine Dean Robert Alpern, M.D., said, "This generous grant from the Grand Challenges in Global Health Initiative provides a boost to Yale's ongoing initiatives in basic science and clinical research. It will advance research on diseases that have an effect on communities worldwide."

The goal of this award is to provide to the research community a suitable model system to test live attenuated vaccines for use in the developing world. Flavell said the mice generated would be made available to the broader scientific community in order to meet the charitable objectives of the Grand Challenges Initiative. Flavell will collaborate with the Institute for Research in Biomedicine in Switzerland and with Regeneron Pharmaceuticals in Tarrytown, New York.

The team will engineer a mouse model in which critical components of the human immune syste
'"/>

Source:Yale University


Page: 1 2

Related biology news :

1. Measurement Challenges In Detecting Cancer Biomarkers
2. Global analysis of membrane proteins
3. Global warming increases oyster sensitivity to pollution
4. Global study shows all tobacco bad for the heart
5. Global warming may warrant new approaches to ecosystem restoration
6. Global warming may have damaged coral reefs forever
7. Global malaria map key weapon in fight against malaria, scientists say
8. Global changes alter the timing of plant growth, scientists say
9. Global map shows new patterns of extinction risk
10. Global sunscreen has likely thinned, report NASA scientists
11. Global survey of lizards reveals greater abundance of animals on islands than on mainland ecosystems
Post Your Comments:
(Date:10/13/2008)...arch may help reveal why different parts of the br...e sclerosis (MS). According to a new study in mice...a protein produced by invading T cells dictates wh...s under fire. The studyfrom researchers at the Uni...e and Washington University in St. Louiswill be pu...
(Date:10/12/2008)...ng up excess neurotrophic factor from neuronal syn...ssion to affect processes such as learning and mem...nts of learning and memory are long-term potentiat...which affect neurons, ability to communicate with ...ay a stronger electrical response to the same leve...
(Date:10/12/2008)...elease is also available in French . , Resear...and GlaxoSmithKline Inc. have identified two genet... astounding sevenfold increase the risk of male pa...t. 12 in the journal Nature Genetics. , About ...ldness by age 45. The condition,s social and econo...
(Date:10/12/2008)...s week Nature Nanotechnology journal (October 12...for Nanotechnology (LCN) at UCL are using a novel ...s of vancomycin, one of the few antibiotics that c...ions such as MRSA. The researchers, led by Dr Rach...d ultra-sensitive probes capable of providing new ...
Breaking Biology News(10 mins):Astrocytes and synaptic plasticity 2Researchers discover baldness gene: 1 in 7 men at risk 2Nanotechnology boosts war on superbugs 2Otter Tail Corporation Holds 2008 Annual Meeting 3A Shareholders Elect Directors 3B Board Declares Quarterly Dividend 16788 1Otter Tail Corporation Holds 2008 Annual Meeting 3A Shareholders Elect Directors 3B Board Declares Quarterly Dividend 16788 2Otter Tail Corporation Holds 2008 Annual Meeting 3A Shareholders Elect Directors 3B Board Declares Quarterly Dividend 16788 3CryoLife Announces Release Date and Teleconference Call Details for First Quarter 2008 Financial Results 16786 1CryoLife Announces Release Date and Teleconference Call Details for First Quarter 2008 Financial Results 16786 2PA Department of Health Warns Consumers About Adverse Reactions From Dietary Supplements 16784 1PA Department of Health Warns Consumers About Adverse Reactions From Dietary Supplements 16784 2Boston Scientific Announces Japanese Approval of Heart Failure Lead 4582 1Boston Scientific Announces Japanese Approval of Heart Failure Lead 4582 2Boston Scientific Announces Japanese Approval of Heart Failure Lead 4582 3
...ing viral infections such as HIV and herpes, a rec...be possible to deactivate such viruses indefinitel... scientists Leor Weinberger and Thomas Shenk hope ...human immunodeficiency virus (HIV) and other virus...The researchers have discovered a specific genetic...
...hnic Institute have found a new pathway by which c... million grant from the National Institutes of Hea...ells decide to stick to a surface, which could lea...his pathway to the physiology and development of o... produce system responses, like the remodeling of ...
...monwealth University Massey Cancer Center today pr...iation of Cancer Research,s annual meeting suggest...or chronic lymphocytic leukemia (CLL). , In this...ate director of translational research, interactio...harmaceuticals) and bortezomib with belinostat (ak...
... more likely to have a Body Mass Index (BMI) of mo...r-olds are five times more likely, according to re...ctrica. , Swedish researchers who studied BMI figu...ades discovered that obesity levels had risen sign...were much more constant among teenagers included i...
Other Biology News:Scientists find potential 'off-switch' for HIV virus 2Scientists find potential 'off-switch' for HIV virus 3Scientists find potential 'off-switch' for HIV virus 4New molecular pathway could reveal how cells stick together 220-year study shows significant rise in childhood obesity, especially among girls 2
(Date:10/13/2008)... No Child Should Die of Diabetes, BRUSSE...iabetes,Federation (IDF) announced today that it i...r action to secure care for the thousands of child...access to care., The meeting, Access to Essential... World, will be held on Saturday, October 25 in Lo...
(Date:10/13/2008)...Mass., Oct. 13 /- Thursday ...g in Boston Scientific,s (NYSE: BSX ),stock. As a...se, a,significant portion of this trading was due ...by Boston Scientific,s co-founders Pete Nicholas a...iday, approximately 31,million shares in aggregate...
(Date:10/13/2008)...ARA, Calif., Oct. 13 /- WebLOQ, Inc.,...r secure and compliant eBusiness and,data-in-motio...ine and,Joint has deployed the WebLOQ ePrivacy sol...he center, along with their healthcare partner, th...al practices, has,implemented WebLOQ,s hosted, on ...
(Date:10/13/2008)...N-LE-PONT, France, October 13 /PRNewswire-FirstCal...precedent, Essilor has now,completed the acquisiti...AG, the world leader in prescription optical equip...e coating units and surfacing,machines, as well as...ported EUR161 million in revenue in 2007 and emplo...
Breaking Biology Technology:International Diabetes Federation Calls for Global Action to Keep All Children With Diabetes Alive 2International Diabetes Federation Calls for Global Action to Keep All Children With Diabetes Alive 3Boston Scientific Provides Update on Involuntary Selling of Its Stock by Co-Founders 2Boston Scientific Provides Update on Involuntary Selling of Its Stock by Co-Founders 3Monterey Spine and Joint Deploys WebLOQ ePrivacy Solution for HIPAA Compliant Health Information Exchange 2Monterey Spine and Joint Deploys WebLOQ ePrivacy Solution for HIPAA Compliant Health Information Exchange 3
...s in chains. Fail to develop the talents of any on...wealth. This quotation is taken from Tony Blairs L...n 1999. It opens chapter one of The Mismanagement ... forthcoming book by British HR researchers Anthon...e main focus of their research was on how universi...
...automatic inventory tracking are not quite here ye...company ePC Group , has a few words to say about ... eInnovate and UW E-Business Institute held June ...s from retailers such as Wal-Mart to implement RFI...ahead of the pack. For others, an RFID implementat...
...lectric Company, recently announced the first pati..., at Froedtert Hospital in Milwaukee. , ,The Lig...organ in one second, scan the whole body in less t... coronaries in fewer than five heartbeats. , ,In a...s, totaling 40 millimeters of anatomical coverage....
... way to summer heat, long weekends and beach vacat...on the nightstand and imagine that we,ll have just...eading. , ,Recently, I had occasion to ask a numbe...gathered up their responses both classic business...etter Summer Reading List: , , A Short History of ...
Other Biology Technology:Talent Mismanagement 2Talent Mismanagement 3RFID: a 30-year project 2New CT scanner by GE Healthcare advances imaging technology 2DEMOletter's Summer Reading List 2DEMOletter's Summer Reading List 3DEMOletter's Summer Reading List 4
Human Granulocyte Macrophage Colony Stimulating Factor, Unconjugated from PeproTech
...ate biopanning experiments, complexity ~2 x 10^9 i...100 pmol), for manual DNA sequencing, -96 gIII Seq...ncing, Host E. coli strain ER2738, Control target ...ocols for surface panning, solution panning, and E...
The CHEMICON Re-Blot Western Blot Recycling Kit is effective for removal of antibodies from Western blots that have been developed with chemiluminescence or radioactive iodine or other isotopes. It i
Immulon 2HB ELISA strips, high binding irradiated surface to provide increased binding affinity for hydrophilic proteins and complexes. Flat bottom works well for reagent injection while provid
Biology Products: