Navigation Links
Grand Challenges in Global Health initiative funds Yale project

Yale has been offered $17 million from the Grand Challenges in Global health initiative to genetically engineer mice with immune systems similar enough to humans to aid in testing the safety and effectiveness of potential vaccines.

Funded by the Bill & Melinda Gates Foundation, the Yale project will be headed by Richard A. Flavell, M.D., Sterling Professor and Chair of Immunobiology at Yale University School of Medicine, and Howard Hughes Medical Institute investigator.

Flavell and his team will study a novel solution to a problem facing many vaccine developers. Some of the most promising vaccines for HIV and a range of other diseases are made from weakened versions of the infectious agent. These cannot be studied in human trials unless researchers are confident that they are safe.

"A big need in the world of vaccine development is the ability to predict whether vaccines for humans are safe and effective," said Flavell. "We are grateful to the Grand Challenges in Global Health Initiative for providing the funds to develop a predictive model system for vaccine testing."

Yale School of Medicine Dean Robert Alpern, M.D., said, "This generous grant from the Grand Challenges in Global Health Initiative provides a boost to Yale's ongoing initiatives in basic science and clinical research. It will advance research on diseases that have an effect on communities worldwide."

The goal of this award is to provide to the research community a suitable model system to test live attenuated vaccines for use in the developing world. Flavell said the mice generated would be made available to the broader scientific community in order to meet the charitable objectives of the Grand Challenges Initiative. Flavell will collaborate with the Institute for Research in Biomedicine in Switzerland and with Regeneron Pharmaceuticals in Tarrytown, New York.

The team will engineer a mouse model in which critical components of the human immune syste
'"/>

Source:Yale University


Page: 1 2

Related biology news :

1. Measurement Challenges In Detecting Cancer Biomarkers
2. Global analysis of membrane proteins
3. Global warming increases oyster sensitivity to pollution
4. Global study shows all tobacco bad for the heart
5. Global warming may warrant new approaches to ecosystem restoration
6. Global warming may have damaged coral reefs forever
7. Global malaria map key weapon in fight against malaria, scientists say
8. Global changes alter the timing of plant growth, scientists say
9. Global map shows new patterns of extinction risk
10. Global sunscreen has likely thinned, report NASA scientists
11. Global survey of lizards reveals greater abundance of animals on islands than on mainland ecosystems
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Grand Challenges Global Health initiative funds Yale project

(Date:4/17/2014)... ideas about domestication derive from Charles Darwin, whose ... animal-breeding practices during the 19th century, a period ... , It is from Darwin that we inherit ... animals from wild species and total human control ... management in this industrial setting has been applied ...
(Date:4/16/2014)... State University researchers have identified a new syndrome called ... and muscle mass with obesity. , "It used to ... better your bones would be because the bones were ... Professor of Nutrition at Florida State. "But, that,s only ...
(Date:4/16/2014)... Nicolas Doucet of the Centre INRSInstitut Armand-Frappier has just received ... in the amount of nearly US$600,000. The 5-year grant is ... called RNases and to explore their biomedical potential in the ... , "Receiving a grant at this level is ...
Breaking Biology News(10 mins):The story of animal domestication retold 2The story of animal domestication retold 3The story of animal domestication retold 4Researchers: Obesity can amplify bone and muscle loss 2High-level NIH grant goes to professor Nicolas Doucet of INRS 2
... U.S. west coast is among the richest ecosystems in the ... a great diversity of marine life. Like coastal regions in ... new study led by scientists at the University of California, ... impacts are highest on marine predators such as whales, seals, ...
... better electronics developed during the last decade, as ... energy storage, and clean water. However, exposure to ... and the environment. As a resource for ... Center for Sustainable Nanotechnology (VTSuN) has joined the ...
... University studying the cause of a rare childhood disease ... new findings may provide clues to understanding more common ... tools to treat them. In today,s online edition ... Hart and Jiali Li in the Department of Cell ...
Cached Biology News:Study maps human impacts on top ocean predators along US west coast 2Study maps human impacts on top ocean predators along US west coast 3Nanomaterials database improved to help consumers, scientists track products 2Nanomaterials database improved to help consumers, scientists track products 3Nanomaterials database improved to help consumers, scientists track products 4Rare childhood disease may hold clues to treating Alzheimer's and Parkinson's 2Rare childhood disease may hold clues to treating Alzheimer's and Parkinson's 3
(Date:1/15/2014)... More than 5 million Americans are ... 3 seniors will die with Alzheimer’s or another dementia, ... have shocked many Americans into looking for ways to ... tragic age-related cognitive disorders. Jonathan Weisman, president of Biohack ...
(Date:1/15/2014)... DTS Language Services, Inc . is pleased to announce ... organizations who need document translations. Clients will now have ... in advance with a selection of nearly 50 life science ... critical factor in clinical and scientific fields, and decrease the ...
(Date:1/15/2014)... AudioNotch is the internet's leading provider of Notched Sound ... Patients listen to sound therapy that is tailor-made for ... to months, their tinnitus volume decreases. , AudioNotch has previously ... Notched White Noise. Now, AudioNotch is pleased to announce to ...
(Date:1/14/2014)... Carahsoft and CDS Federal Services have scheduled a ... EST (11am PST), “Natural Language Processing: Converting Raw Data ... can turn raw, heterogeneous data into actionable knowledge to ... webinar will last approximately one hour. , Synopsis: Big ...
Breaking Biology Technology:Biohack Pure Offers 5 Tips for Increasing Memory in 2014 2DTS Improves Efficiency for Life Science Document Translations 2Webcast - Natural Language Processing: Converting Raw Data into Actionable Knowledge – Hosted by Carahsoft and CDS Federal Services 2
... , More sensitive than ... Linear quantitation of mRNA targets , over a 106-fold range ... as 500 fg total RNA 1/20th of a single cell! , Fast, ... 15 min , , ...
... Fluorescence activated cell sorting (FACS) is a , ... individual cells using fluorescent probes that bind specifically to ... commonly used to collect , cells of a given ... , Figure 1.Linear Amplification from 1-1000 Cells. , ...
... Remove >90% of mammalian RNA from , ... Simple procedure takes less than 2 hours , ... with , MICROB Express Bacterial mRNA Purification Kit ... bacterial RNA isolated from host cells , ...
Cached Biology Technology:HIGH SENSITIVITY qRT-PCR 2HIGH SENSITIVITY qRT-PCR 3HIGH SENSITIVITY qRT-PCR 4HIGH SENSITIVITY qRT-PCR 5Cells-to-cDNA II Using FACS Sorted Cells 2Bacterial RNA Isolation From Infected Eukaryotic Hosts 2Bacterial RNA Isolation From Infected Eukaryotic Hosts 3Bacterial RNA Isolation From Infected Eukaryotic Hosts 4Bacterial RNA Isolation From Infected Eukaryotic Hosts 5Bacterial RNA Isolation From Infected Eukaryotic Hosts 6
...
... inhibition of RNase A-type ribonucleases Product Description: ... nonhuman origin that binds noncovalently and inactivates ... B, and C). It does not interfere ... or CL3. QIAGEN RNase Inhibitor inhibits greater ...
...
... Radiochemical Purity is >95%\nNEN Radiolabeled Ligands\n\nReceptor-related ... continual availability of new radiolabeled ligands selected ... offers a wide range of products and ... including over 400 state-of-the-art radioligands. If you ...
Biology Products: