Navigation Links
Grabbing addiction by the tail

s were removed from the cell surface, whether the process could be halted, and, if it could, whether the addicted rats would exhibit fewer signs of behavioral sensitization. Wang's research has made significant progress toward answering these questions.

The researchers began by building a peptide ?a long molecule made from a string of amino acids ?with a structure similar to the tail of the glutamate receptor that is anchored inside the cell. In addiction, cellular machinery tugs on this tail, pulling the entire receptor into the cell. Without its business end sticking out into the synapse, or space between neurons, the receptor no longer works.

Wang's peptide tricks the cellular machinery into tugging on it instead of the receptor's tail. "Once it gets inside the neuron, the peptide competes with the receptor for binding to the machinery," Wang explained. With the cellular machinery otherwise occupied, the glutamate receptors stay on the cell surface, where they continue to receive signals.

After confirming these results in cell cultures, Wang and colleagues tested the peptide in rats that had been given amphetamine once every other day for 20 days. During this period, the animals displayed stereotypical behavior such as repeated sniffing, licking, and grooming, indicating a craving for the drug. Such behavior parallels the compulsive thought patterns that people addicted to drugs experience, said Anthony Phillips, Wang's colleague at the University of British Columbia and a co-author of the article.

After keeping the rats drug-free for 21 days, the researchers gave the animals a small amount of drug again. The rats immediately displayed intense stereotypical behavior ?a sign of behavioral sensitization. The behavior meant that the glutamate receptors in the animals' neurons were rapidly internalized, said Wang. "It's the trigger that leads to sustained motivation to seek a drug."

In contrast, addicted animals who receive
'"/>

Source:Howard Hughes Medical Institute


Page: 1 2 3

Related biology news :

1. Gene controlling circadian rhythms linked to drug addiction
2. A link is found between morphine addiction and the tendency to explore
3. Team discovers possible universal strategy to combat addiction
4. Smokers invite to test vaccine against nicotine addiction
5. Altered perception of reward in human cocaine addiction
6. Study highlights new and cheaper way to treat heroin addiction
7. An elephant tail
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Grabbing addiction the tail

(Date:10/17/2014)... This news release is available in German . ... need millions of sperms every day in order to reproduce? ... questions are the topic of the latest issue of the ... 16th, 2014). The evolutionary biologist Steven Ramm from Bielefeld University ... nature, it is not unusual for a female to copulate ...
(Date:10/16/2014)... constantly wages war on the human body. Battles ... stalemate. In pancreatic cancer, this stalemate—known as tumor ... aggressively malignant, a phenomena that is poorly understood. ... the laboratory of Salvatore Torquato, a Professor of ... conditions surrounding tumor dormancy and the switch to ...
(Date:10/16/2014)... Melbourne researchers have challenged conventional thinking on how the ... new mechanism for how bowel cancer starts. , The ... maintaining and regenerating the ,crypts, that are a feature ... are involved in bowel cancer development, a controversial finding ... existence. , Using 3D imaging technologies, Dr Chin Wee ...
Breaking Biology News(10 mins):Sperm wars 2Modeling tumor dormancy 2Cryptic clues drive new theory of bowel cancer development 2
... Ariz. One of the great mysteries of life is how ... into something as complex as a living cell? For more ... steps on the road to life. Until recently, their focus has ... have been synthesized on the early Earth, or perhaps in space. ...
... Cladophora in the Great Lakes, including phosphorus-rich Lake Erie, ... onto the radar of scientists, including Mercyhurst University biologist Steven ... that incidences of avian botulism are linked to Cladophora ... pathogens have sparked renewed attention in the nuisance algae. ...
... than 70 humans and 200 Asian elephants every year. One ... moving the elephants into ranges away from humans, often into ... that include elephants raiding crops, breaking into homes and injuring ... to be published Dec. 7 in PLOS ONE ...
Cached Biology News:ASU researchers propose new way to look at the dawn of life 2ASU researchers propose new way to look at the dawn of life 3Grant furthers Mercyhurst research for human pathogens in Great Lakes 2Relocating elephants fails to decrease human-wildlife conflict 2
(Date:10/18/2014)... The Asian arthroscopic devices report defines and segments ... of revenue. The arthroscopic devices market in Asia is ... a CAGR of 6.5% from 2013 to 2018. , ... market, to get an idea of the in-depth analysis ... of arthroscopic devices market in the same region, and ...
(Date:10/18/2014)... NY (PRWEB) October 18, 2014 The ... healthy rate in the five years to 2014. The ... federal renewable energy tax credits that encouraged the use ... enacted renewable portfolio standards (RPSs), which require local utilities ... of their total energy portfolio. Increased campaigning for green ...
(Date:10/17/2014)... received a $451,781 Air Force Office of Scientific Research ... and nano-scale level that will provide clues for predicting ... and Aerospace Engineering, said the new technology and process ... of an aircraft,s wing., "We,ll be able to determine ... at it on this scale," Huang said. "Certain patterns ...
(Date:10/17/2014)... Bioquell, provider of germ-eliminating robots and ... around the world to decontaminate locations where Ebola-infected ... many places the hydrogen peroxide vapor technology is ... and at the National Institutes of Health (NIH) ... utilized to decontaminate patient rooms, equipment, and an ...
Breaking Biology Technology:The Asian arthroscopic devices market is estimated to grow to $712.3 million by 2018 - New Report by MicroMarket Monitor 2The Asian arthroscopic devices market is estimated to grow to $712.3 million by 2018 - New Report by MicroMarket Monitor 3The Asian arthroscopic devices market is estimated to grow to $712.3 million by 2018 - New Report by MicroMarket Monitor 4Biomass Power in the US Industry Market Research Report from IBISWorld Has Been Updated 2Biomass Power in the US Industry Market Research Report from IBISWorld Has Been Updated 3UT Arlington project to detect possible damages in aircraft parts early in process 2Bioquell’s Vapor Producing Robots Selected to Combat Ebola in Hospitals Around the World 2Bioquell’s Vapor Producing Robots Selected to Combat Ebola in Hospitals Around the World 3Bioquell’s Vapor Producing Robots Selected to Combat Ebola in Hospitals Around the World 4Bioquell’s Vapor Producing Robots Selected to Combat Ebola in Hospitals Around the World 5Bioquell’s Vapor Producing Robots Selected to Combat Ebola in Hospitals Around the World 6
... , DURHAM, N.C., Nov. 25 Research ... water purification system NanoPure(TM) developed from carbon nanotubes to ... Viswarup and other leaders in Hyderabad, India today. Initial ... confirmed that the majority of the drinking water available ...
... ON, Nov. 25 /PRNewswire/ - Cytochroma today announced the appointment ... Moldt will replace Mr. Ulrik Spork as the Novo A/S ... remains unchanged at six members. , "We are very pleased ... to benefiting from his experience and guidance as Cytochroma continues ...
... This release is available in German . ... RFID tags (Radio Frequency Identification) are increasingly finding their way ... or goods and identify them automatically by radio frequency. The ... the label. Smart labels can be affixed to goods under ...
Cached Biology Technology:North Carolina-based Cnanoz Unveils NanoPure(TM) to Government Leaders in Hyderabad, India 2Cytochroma Announces Appointment of Peter Moldt to Board of Directors 2Intelligence inside metal components 2
Recombinant Feline IFN-alpha...
... ELISA Development kit contains the basic components ... to measure natural and recombinant canine Monocyte ... supernates and serum.1 Each kit contains sufficient ... 96-well plates, provided that the following conditions ...
ROCK-1 (cleaved) Monoclonal Ab 100 ug purified mouse monoclonal antibody. Clone# 12M03. Reacts with human. Tested in Western blot analysis....
Spastin (Sp 3G11/1)...
Biology Products: