Navigation Links
Gov't Creates Gene Database of Normal Human Tissues

ed so many tissue samples (158), or included samples of tissue from different parts of the same organs from multiple donors. Tissue samples were harvested an average of 11 hours after death, from males and females of different ethnic groups, ranging from ages 3 months to 39 years old.

The very large cDNA microarray they constructed has more than 42,000 detectors built into two chips using verified cDNA libraries upon which many other researchers currently rely. Analyzing the organ tissue with this tool allowed Khan and his team to identify 18,927 genes that constitute their database. "We found that each organ had a unique expression level profile," said Khan, "and, remarkably, any truly random subset of 1,000 genes could distinguish one organ from another."

Each organ revealed a very distinct profile of active genes, different from all others. However, the gene profiles from different organs that share similar biological functions also showed patterns of expression. For example, though the cerebrum and the cerebellum are two distinct parts of the brain, located apart from each other and doing very different jobs, their gene expression profiles reflected their commonality as part of the nervous system. Similarly, "muscle contraction" genes were found in skeletal muscle, smooth muscle tissue, and the heart -- all organs that share a common way of functioning.

To illustrate the kind of useful data that can emerge from using this tool, Khan's team analyzed 100 samples of the most common pediatric solid tumor cancer, neuroblastoma (NB), which accounts for 7 percent to 10 percent of all childhood cancers. Even though the tumor samples were taken from a variety of patients with different stages of cancer, the database kicked out a list of 19 genes that were consistently overexpressed compared to normal brain tissue.

"All of these genes are involved in one way or another with the kinds of activities associated with the development of cancer -
'"/>

Source:NIH


Page: 1 2 3 4

Related biology news :

1. PANTHER Protein Classification System Database 5.0
2. Software Tool for Converting Scientific Text into a Database of Functional Relationships
3. IMF Launches World’s First DNA Database for Myeloma Patients
4. Leptin-signaling Protein Maintains Normal Body Weight And Energy Balance In Mice
5. Normal chromosome ends elicit a limited DNA damage response
6. FDA Approves Human Hookworm Vaccine for Phase I Safety Trials
7. New Clues Add 40,000 Years to Age of Human Species
8. Human Cells Filmed Instantly Messaging for First Time
9. Analysis Of Human Genome To Predict The Development Of Illnesses
10. Human Eggs Can Develop From Ovarian Surface Cells In Vitro
11. Determining The Fate Of Cells In The Human Body
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Gov Creates Gene Database Normal Human Tissues

(Date:10/16/2014)... are anything but sustainable: environmental damage to soil ... increasingly evident. Despite their disadvantages, however, monocultures remain ... the sole possibility of achieving higher yields in ... an ecology professor at the University of Zurich, ... forestry. After all, a new study carried out ...
(Date:10/15/2014)... N.Y. , Oct. 15, 2014 ... solutions for home and community-based care, today announced ... of implementing Sandata,s Santrax® Electronic Visit Verification™ Solution ... Services is a home health company founded in ... Texas . The study ...
(Date:10/15/2014)... The Ebola virus is spreading rapidly and to an ... experienced in the past and the virus shows a ... been recorded before. For this reason, the German National ... of Science and Engineering, and the Union of the ... statement on the Ebola epidemic today. , In the ...
Breaking Biology News(10 mins):Plant communities produce greater yield than monocultures 2Plant communities produce greater yield than monocultures 3Sandata Announces Case Study with Quality Care Services, Inc. 2Academies call for consequences from the Ebola virus epidemic 2Academies call for consequences from the Ebola virus epidemic 3Academies call for consequences from the Ebola virus epidemic 4Academies call for consequences from the Ebola virus epidemic 5
... each living cell needs both to build new and ... a number of intracellular systems work in concert to ... damaged proteins. When proteins or peptides mutate, they can ... intracellular environment. In Huntington's disease (HD) the disease provoking ...
... Wildlife Conservation Society working in Iran has successfully fitted ... marking the first time this highly endangered population of ... found throughout the continent, Asiatic cheetahs now live only ... Kavir Desert. WCS's government partner in Iran, the Department ...
... An international group of scientists has announced a ... describe the activities of genes in living organisms. ... use to describe the complex events that occur ... host. Understanding these events is crucial for developing ...
Cached Biology News:Proteasome activator enhances survival of Huntington's disease neuronal model cells 2In Iran, cheetahs collared for the first time 2Uniform language for describing genes of pathogenic and beneficial microbes 2Uniform language for describing genes of pathogenic and beneficial microbes 3
(Date:10/20/2014)... , Oct. 20, 2014  GenVec, Inc. (NASDAQ: ... Horovitz , Ph.D., from its board of directors effective on ... August 2003, and served as its chairman from June 2006 ... the Nominating and Corporate Governance and Audit Committees of the ... than a decade of dedicated service to GenVec, and its ...
(Date:10/20/2014)... 20, 2014 OncLive® ... Cancer Center at Thomas Jefferson University has joined ... the Strategic Alliance Partnership program, the Sidney Kimmel ... to raise awareness of the Center’s cutting-edge research ... projects. Clinicians and other health care professionals from ...
(Date:10/20/2014)... Local veterinary surgeon, Dr. Tim McCarthy is ... donor stem cells for dogs with osteoarthritis. Dr. McCarthy ... performed clinical stem cell therapy for 7 years. The ... a single injection of donor stem cells into one ... and inflammation in the treated joints. , Candidates ...
(Date:10/19/2014)... 20, 2014 OCTOBER 20-22, ... (ABIM). ABIM will take place at ... about ABIM 2014 is now available at ... representing companies and organizations from all over ... information on the latest products and developments ...
Breaking Biology Technology:Zola P. Horovitz To Retire From GenVec Board 2Sidney Kimmel Cancer Center at Thomas Jefferson University Partners With OncLive 2Sidney Kimmel Cancer Center at Thomas Jefferson University Partners With OncLive 3Cascade Veterinary Referral Center Seeks Candidates for an Investigational Study of Stem Cells for Dogs with Arthritis 2
... Norlight Telecommunications , a Brookfield, Wisconsin, ... Protocol service for small and medium-sized businesses in Wisconsin ... to offer the service to businesses in Minnesota, Michigan, ... marketing. , , IPLive will integrate voice, data ...
... Wisconsin-based Analogix joins French company to provide drug purification ... businesses Alliant Energy announces dip in ... furniture store selects Citrix IT tools ... purification products , Analogix , a maker of ...
... courtesy of Silicon Graphics Inc. Chippewa Valley, Wis. ... fastest supercomputer in about 129 days, and it was the ... SGI announced the completion of the $50 million project for ... after the space shuttle that crashed last year, runs on ...
Cached Biology Technology:Tech Digest: whats moving in the Midwest (11/1/04) 2SGIs Wisconsin branch builds fastest supercomputer yet in four months 2
Yields DNA greater than 50 kb in length from yeast, fungi, Gram neg. and Gram pos. bacteria...
Mouse monoclonal [1Q17] to TGE Virus peplomer ( Abpromise for all tested applications)....
Jak3 Antibody Ship: Hot Store: -20 C...
14-3-3 tau Antibody Shipping Temperature: HOT Storage Temperature: -20C...
Biology Products: