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Gold nanoparticles could improve antisense cancer drugs

DNA-modified nanoparticles act as messenger RNA "sponges" that bind to their targets and prevent them from being converted into proteins.

In their experiments the researchers targeted mRNA sequences that code for enhanced green fluorescent protein (EGFP) expressed in a mouse cell. The antisense sequence of the DNA attached to the nanoparticles was complementary to the mRNA for EGFP expression. When the nanoparticles were introduced to the cells the fluorescence dimmed -- a result of the nanoparticles binding to the mRNA and shutting down the protein's expression, or fluorescence.

"In the future, this exciting new class of antisense material could be used for the treatment of cancer and other diseases that have a genetic basis," said Mirkin, who is George B. Rathmann Professor of Chemistry, professor of medicine and professor of materials science and engineering.

In addition to Mirkin, other authors on the Science paper are Nathaniel L. Rosi (co-first author), David A. Giljohann (co-first author), C. Shad Thaxton, Abigail K. R. Lytton-Jean and Min Su Han, all from Northwestern University.


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Source:Northwestern University


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