Navigation Links
GlycoFi announces the first production of antibodies with human glycosylation in yeast

Researchers at GlycoFi and Dartmouth College have reported the first production of monoclonal antibodies with human sugar structures in yeast.

This research, published online January 22 and in the February issue of the journal Nature Biotechnology, demonstrates that antibodies with human sugar structures (glycosylation) can be produced in glyco-engineered yeast cell lines, and that by controlling the sugar structures of antibodies, their therapeutic potency can be significantly improved. Moreover, this same approach offers the potential to improve other glycosylation-dependent drug properties (such as solubility, half-life, or tissue distribution). Given the mature and well-established nature of yeast-based protein production technology, the reported work also promises to improve the production and scale-up economics of antibody manufacturing.

Monoclonal antibodies constitute the majority of therapeutic proteins currently in clinical and preclinical development, and additionally represent some of the largest selling products to emerge from the biotechnology industry. Monoclonal antibodies often achieve their therapeutic benefit through two binding events: 1) the binding of the variable domain of the antibody to a specific marker protein, such as the CD20 receptor on the surface of cancer cells, followed by 2) the recruitment of immune system "effector" cells that bind the constant domain of the antibody and destroy the cancer cell to which the antibody is bound. Research has shown that this process, known as antibody dependent cell cytotoxicity (ADCC), is sensitive to the composition of sugars (or "glycans") in the antibody's constant region. Moreover, in the absence of these sugars, the antibodies can bind to antigens but do not elicit ADCC.

"Mammalian cell cultures currently used for most therapeutic protein production produce a mixture of glycoforms and typically do not allow for the control of glycosylation," said Tillman Gerngross, chief
'"/>

Source:JKureczka@comcast.net


Page: 1 2 3

Related biology news :

1. GlycoFi and Dartmouth report full humanization of yeast glycosylation pathway in Science
2. Wiley announces publication of Databasing the Brain
3. Nonlinear Dynamics announces more details of its global partnership with PerkinElmer
4. Neurologix announces positive results of gene therapy clinical trial in Parkinsons disease
5. Eisai announces Phase II data on E7389, a potential new therapy for the treatment of breast cancer
6. NHGRI announces new sequencing targets
7. CHAVI announces international search for genes affecting HIV response
8. NHGRI announces latest sequencing targets
9. MUHC announces a transplant first in Quebec
10. St. Jude announces breakthrough in eye cancer treatment
11. NIH announces phase III clinical trial of creatine for Parkinsons disease
Post Your Comments:
(Date:4/13/2015)... 2015  higi, a leading cloud-based consumer engagement platform ... engage with their communities around health and wellness, announced ... secure API.  ... affordable, and convenient vehicle to receive validated health information ... The API will allow higi,s trusted partners, on ...
(Date:4/2/2015)... 2, 2015 In the ... far outperforms the strongest competitors, showing outstanding performance ... the system is capable of a throughput of ... up to be ten times faster than most ... performance.      (Photo: http://photos.prnewswire.com/prnh/20150402/738673-a ...
(Date:4/1/2015)... 2015   Medisafe ™, the leading global medication ... iOS and Android smartphones and tablets, ... the platform to allow patients to track and correlate ... time, patients will be able to visualize in real-time ... biometrics, such as glucose levels and blood pressure. ...
Breaking Biology News(10 mins):higi Launches Seamless Access to HIPAA-Compliant Health Outcomes and Activity Data 2higi Launches Seamless Access to HIPAA-Compliant Health Outcomes and Activity Data 3DERMALOG AFIS Emerges as Performance Winner in NIST Benchmark Test 2DERMALOG AFIS Emerges as Performance Winner in NIST Benchmark Test 3Medisafe Announces Launch of Biometric Integration, Enabling Patients to Stay Adherent to Their Meds and See Tangible Health Results 2
... BAHAMAS (September 29, 2009)It is well known that people from ... the pristine waters, spectacular coral reefs and great fishing. Tourism ... employs up to 60% of the total workforce in the ... possible for visitors to come and enjoy the natural beauty ...
... new study of microscopic marine microbes, called phytoplankton, by ... University of South Carolina has solved a ten-year-old mystery ... ocean. Roughly a decade ago scientists discovered ... matter. Not only were the researchers surprised to find ...
... ARBOR, Mich.---Brain implants that can more clearly record signals ... the University of Michigan. The findings could eventually lead ... Parkinson,s disease and paralysis. Neural electrodes must work ... the electrodes are implanted, the brain first reacts to ...
Cached Biology News:Combining sun, sand and science in the Bahamas 2Combining sun, sand and science in the Bahamas 3Mystery solved: Marine microbe is source of rare nutrient 2Mystery solved: Marine microbe is source of rare nutrient 3A step toward better brain implants using conducting polymer nanotubes 2A step toward better brain implants using conducting polymer nanotubes 3
(Date:4/29/2015)... 29, 2015 SPIE DSS, ... on the East Coast, reaffirmed its value last week ... developers, and industry suppliers to meet and advance the ... applications. , The event included 55 conferences in two ... sensing and imaging -- and an exhibition showcasing 382 ...
(Date:4/29/2015)...   Doximity , the leading online medical network ... members, announced a new, instant method for physicians to ... one click, all US physicians can quickly submit their ... an open job opportunity, and a recruiter will reach ... percent of physicians are open to new jobs, and ...
(Date:4/29/2015)... AlloSource ®, one of the ... and soft-tissue allografts for use in surgical procedures ... the launch of AlloSkin™ AC, an acellular dermal ... (CMS) also moved AlloSkin™ RT, a meshed human ... category for reimbursement. "AlloSource is committed ...
(Date:4/29/2015)... York, NY (PRWEB) April 29, 2015 Gene ... and replace it with the normal gene in human cardiac ... Cardiovascular Research Center at Icahn School of Medicine at Mount ... of Nature Communications. , “Genetic mutations, the small random, ... culprits in the weakening heart muscle seen in patients with ...
Breaking Biology Technology:SPIE DSS provides venue for collaboration vital to research, applications advances 2SPIE DSS provides venue for collaboration vital to research, applications advances 3SPIE DSS provides venue for collaboration vital to research, applications advances 4Doximity Offering Hospitals Easy, Efficient Physician Application Tool 2AlloSource Announces New Possibilities In Wound Care 2Gene Therapy Clips Out Heart Failure Causing Gene Mutations 2Gene Therapy Clips Out Heart Failure Causing Gene Mutations 3Gene Therapy Clips Out Heart Failure Causing Gene Mutations 4
... but the way we think about work life isn't. ... work, but nobody is ready to translate this into ... equality and life satisfaction." , ,This quote by ... Rhonda Rappaport, Suzan Lewis and Richenda Gambles entitled, "Work-Personal ...
... Wis. - Guitarists and other musicians will find a ... City, thanks to a deal struck by a local online ... music store, reached an agreement Friday to distribute the ... , ,Musicnotes now will be able to offer its customers ...
... ranked among the best places to work for professionals ... they offer employee incentives designed to boost worker production ... Insurance Co. , Milwaukee, American Family Insurance Group ... Bay, all fell within the top 75 in a ...
Cached Biology Technology:Work-life imbalance - A global problem getting worse 2Work-life imbalance - A global problem getting worse 3Work-life imbalance - A global problem getting worse 4Work-life imbalance - A global problem getting worse 5Wisconsin companies among Best IT Workplaces 2
... performance agitation and temperature control for microbiology ... wells independently and is suitable for DASGIP ... working volume. Its temperature ranges from approximately ... well is equipped with an individual electrical ...
... analyzes and reports the data from any one ... a chart recorder. The final data is sent ... end-point selection is automatic for Systolic, Mean, Heart ... The user is always in the position to ...
... DNA microarrays designed for your specific applications ... Paraflo microfluidic synthesis platform. Thousands of customer ... LC Sciences can provide assistance with custom ... part of our comprehensive Custom DNA Microarray ...
... RNA aptamer screening and binding optimization and ... microfluidic on-chip synthesis platform. These microarrays are ... Aptamer Microarray Service. Probe Content ... contains greater than 1500 known aptamer sequences. ...
Biology Products: