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GlycoFi and Dartmouth report full humanization of yeast glycosylation pathway in Science

of producing higher recombinant protein titers, shorter fermentation times, and the ability to grow in chemically defined media, without risk of viral contamination from animal-derived ingredients.

"Switching to this technology will also provide improvements in product uniformity and overall production economics," Dr. Gerngross said. He noted that the GlycoFi and Dartmouth research team had previously published work showing how a panel of glyco-engineered yeast cell lines, displaying a more limited repertoire of human glycosylation reactions, had allowed the scientists to study the relationship between specific glycosylation structures on antibodies and their killing activity on cancer cells. Using this technology, the team had identified glycosylation structures that significantly improved an antibodies ability to kill cancer cells compared to the same antibody manufactured using mammalian cell culture.

"By engineering yeast to perform the final and, most complex step of human glycosylation, we are now able to conduct far more extensive structure-function investigations on a much wider range of therapeutic protein targets," Dr. Gerngross commented.
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Source:JKureczka@comcast.net


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