Navigation Links
Ghost protein leaves fresh tracks in the cell

rrectly to the cell membrane." In fact, the genetically engineered flies often survived to adulthood, while mutants that lacked spectrin altogether died very early in development.

Meanwhile, Dubreuil discovered that another region of spectrin, called the PH domain, unexpectedly played an critical role. Removing the PH domain left spectrin unable to bind to the membrane in certain cells, and those flies died.

Dubreuil's research seeks to clarify how these proteins function in different cells. The hope is that researchers may one day create therapeutic molecules to compensate for genetic lesions in diseases such as hereditary anemia, Duchenne muscular dystrophy, cardiac arrhythmia and the degenerative brain disease spinocerebellar ataxia 5.

"As we learn more about mutations involving spectrin and their relationships to human diseases, we're going to have more and more questions about how these mutations affect specific functions of the molecule," he said.


'"/>

Source:University of Illinois at Chicago


Page: 1 2

Related biology news :

1. New, automated tool successfully classifies and relates proteins in unprecedented way
2. New binding target for oncogenic viral protein
3. Controversial drug shown to act on brain protein to cut alcohol use
4. Timing is everything: First step in protein building revealed
5. UWs Rosetta software to unlock secrets of many human proteins
6. Researchers find how protein allows insects to detect and respond to pheromones
7. Signaling protein builds bigger, better bones in mice
8. Ancient olfaction protein is shared by many bugs, offering new pest control target
9. Automatic extraction of gene/protein biological functions from biomedical text
10. Discovery of key proteins shape could lead to improved bacterial pneumonia vaccine
11. Scientists develop new color-coded test for protein folding
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Ghost protein leaves fresh tracks the cell

(Date:12/11/2009)... demand for premium fruit increases, growers are being ... And to boost their bottom line, orchard owners ... fruit quality while reducing labor costs. , Hand ... produce larger, healthier fruit, is among the most ... on fruit production overhead, and, ultimately, prices paid ...
(Date:12/11/2009)... that green plants photosynthesize, absorb carbon dioxide and ... effects that photosynthesis has had on Earth. One ... and evolution of photosynthesis is Jeffrey Touchman, assistant ... Sciences. , Oxygen, one of the by-products of ... descendants (including algae and higher plants), transformed the ...
(Date:12/11/2009)... and degrade the diverse types of defective proteins and ... Sabine C. Horn, Professor Thomas Sommer, Professor Udo Heinemann ... for Molecular Medicine (MDC) Berlin-Buch, Germany, have now found ... complex that plays a critical role in the quality ... identification and disposal of various defectively produced proteins. ( ...
Breaking Biology News(10 mins):Horizontal string trimmer reduces labor costs, increases peach size 2'Extreme' genes shed light on origins of photosynthesis 2'Extreme' genes shed light on origins of photosynthesis 3MDC researchers identify a scaffold regulating protein disposal 2One in Four Teen Girls Have STDs 61946 1One in Four Teen Girls Have STDs 61946 2One in Four Teen Girls Have STDs 61946 3Fat around the middle increases the risk of dementia 61944 1Diabetics show alarming increase in morbid obesity 61942 1Diabetics show alarming increase in morbid obesity 61942 2
... about what it,s like to be a bat, but for ... aspects of the human brain and nervous system. , Cynthia ... at the University of Maryland, College Park, Md., is one ... the heads of bats. , Her new research suggests there ...
... of Natural Science, or MNS, recently participated in a project ... world. This study the largest study of bird genetics ... evolutionary tree, but completely redrawn it. The results of this ... genetic resources collection, will be published in Science ...
... Research by two Kansas State University scientists could ... oil-rich algae in oceans for biofuel. , K-State,s ... manufacturing systems engineering, and Wenqiao "Wayne" Yuan, assistant ... a $98,560 Small Grant for Exploratory Research from ...
Other Biology News:What it's like to be a bat 2What it's like to be a bat 3'Early bird' project really gets the worm 2Algae from the ocean a sustainable energy source of the future 2
(Date:12/14/2009)... has completed the delivery of Brookfield Engineering’s Powder Flow Tester ... enclosure with a smaller footprint and more compact design. ... ... 2009 -- ThermoFab, a US-based thermoforming company, has completed the ... move from sheet metal to a plastic enclosure with a ...
(Date:12/11/2009)... BOULDER, Colo., December 10, 2009 miRagen Therapeutics, ... lives by developing innovative microRNA-based therapeutics for cardiovascular ... data demonstrating that microRNA-206 (miR-206) plays a crucial ... (ALS or Lou Gehrig,s disease) and in neuromuscular ... in the December 11 issue of the journal ...
(Date:12/11/2009)... December 11 Algeta ASA (OSE: ... first clinical center in the,US, the Tulane ... patients,in the phase III clinical study of ... hormone-refractory) prostate cancer,(CRPC) that has metastasized to ... The ALSYMPCA (ALpharadin in SYMptomatic Prostate CAncer) ...
(Date:12/11/2009)... Hatboro, PA December 11, 2009 -- Esco announces the opening of ... will serve as a technical service, training and logistics center to ... area of New Product Introductions (NPI) for temperature-controlled laboratory equipment. ... ... announces the opening of a NEW 2nd North American facility in ...
Breaking Biology Technology:Thermofab Helps Brookfield Engineering Move To A Compact Custom Plastic Enclosure 2miRagen announces discovery of key microRNA implicated in Lou Gehrig's disease 2Algeta Announces First US Patient Randomized in ALSYMPCA Phase III Study at Tulane Cancer Center, New Orleans 2Algeta Announces First US Patient Randomized in ALSYMPCA Phase III Study at Tulane Cancer Center, New Orleans 3Algeta Announces First US Patient Randomized in ALSYMPCA Phase III Study at Tulane Cancer Center, New Orleans 4
... S*BIO Pte Ltd, a cancer therapeutics,company, today announced ... led by Bio*One Capital and new investor Aravis ... Fund advised by,Adamant Biomedical Investments AG and Zurcher ... fund the development efforts of its,two lead compounds, ...
... SYDNEY, Australia, Oct. 19 /Xinhua-PRNewswire-FirstCall/ --,Pharmaceutical company ... it had received approval to market Aridol ... Aridol is indicated for measuring airway hyperresponsiveness ... countries - Denmark, Finland, France, Germany,Greece, Ireland, ...
... Mattel Children,s Hospital UCLA today announced the launch ... explore the future of personalized medicine for children, ... is one of the world,s first dedicated solely ... , "Why develop a nanopediatrics program? Because children ...
Other Biology Technology:S*BIO Completes US$26 Million Equity Financing 2S*BIO Completes US$26 Million Equity Financing 3S*BIO Completes US$26 Million Equity Financing 4Pharmaxis Aridol Approved for Sale in Switzerland 2Mattel Children's Hospital UCLA launches program in nanopediatrics 2
... of Ham's F-12 was developed for culturing ... fusion. The modification consists of doubling the ... acid. The salt concentrations have been altered ... zinc sulfate per liter, which may render ...
... is an 18 amino acid synthetic peptide whose sequence corresponds to ... peptide is (amino to carboxy terminus): M(1) - A - S ... A - S - P - R - D - A ... peptide may be used for neutralization and control experiments with the ...
... Kit enables complete conversion of unmethylated ... 6 hours. The highly sensitive method ... degradation and a spin-column-based purification and ... reliable results for all downstream applications. ...
... or individual RNA sequences from high throughput synthesis ... RNAs from LC Sciences. These products provide a ... of DESIGNED sequences delivered in a microtube as ... a single verified RNA sequence. This is a ...
Biology Products: