Navigation Links
Ghost protein leaves fresh tracks in the cell

Spectrin and ankyrin are two essential proteins acting like bricks and mortar to shape and fortify cell membranes. But distinguishing which protein is the brick and which is the mortar has turned out to be difficult. New evidence suggests that spectrin can do both jobs at once.

Ron Dubreuil, associate professor of biological sciences at the University of Illinois at Chicago, reports the finding in the Oct. 23 issue of the Journal of Cell Biology.

Spectrin was first discovered in red blood cells, where it forms a protein scaffold under the cell's membrane. It was named for its ability to maintain the shape of cell "ghosts," which have been emptied of their contents. Ankyrin serves as the mortar that attaches spectrin to the red blood cell membrane.

Dubreuil and his UIC co-workers have spent a decade looking at different types of cells -- mostly epithelial -- trying to learn what cues tell spectrin where to assemble in cells. They use the fruit fly as their test animal because its genetic makeup has many striking similarities to humans.

"In our study, we showed spectrin doesn't have to bind to ankyrin to do its job," said Dubreuil. "This hints at a complexity we never had any idea about in trying to understand how these molecules work."

Dubreuil and his colleagues initially assumed that ankyrin was the key to targeting spectrin in all cells. But research in many laboratories had failed to find a cue for targeting that acted through ankyrin, so Dubreuil reworked his hypothesis.

"We decided to throw out our assumptions and start fresh," he said.

A laboratory fly was genetically engineered so that spectrin could no longer bind to ankyrin -- which, Dubreuil assumed, meant that spectrin should no longer attach to the membrane.

"We thought that was going to kill the function of the protein," he said, "but it didn't affect the ability of the protein to reach its destination at all. The molecule targeted co
'"/>

Source:University of Illinois at Chicago


Page: 1 2

Related biology news :

1. New, automated tool successfully classifies and relates proteins in unprecedented way
2. New binding target for oncogenic viral protein
3. Controversial drug shown to act on brain protein to cut alcohol use
4. Timing is everything: First step in protein building revealed
5. UWs Rosetta software to unlock secrets of many human proteins
6. Researchers find how protein allows insects to detect and respond to pheromones
7. Signaling protein builds bigger, better bones in mice
8. Ancient olfaction protein is shared by many bugs, offering new pest control target
9. Automatic extraction of gene/protein biological functions from biomedical text
10. Discovery of key proteins shape could lead to improved bacterial pneumonia vaccine
11. Scientists develop new color-coded test for protein folding
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Ghost protein leaves fresh tracks the cell

(Date:5/7/2015)... , May 7, 2015 ... sensors, FPC1022 and FPC1035, FPC,s smallest touch fingerprint ... are mainly considered for integration on the backside ... smartphone OEMs increased possibilities to integrate touch fingerprint ... size also improves possibilities for module manufacturers to ...
(Date:5/6/2015)... AVIV, Israel , May 6, 2015 ... world,s most established helmet producer, announced today that they ... Smart Helmet, the world,s first bio-sensing cycling helmet and ... be released in two new colors in order to ... for the product. In addition, LifeBEAM and Lazer announced ...
(Date:5/5/2015)... May 5, 2015, NXT-ID, Inc. (NASDAQ: NXTD ... on the growing mobile commerce market, reminds investors and media ... Officer, is presenting  at CARTES SECURE CONNEXIONS AMERICA 2015, held ... The three-day conference is organized into a ... in is themed Global Fraud: Where is the Trust ...
Breaking Biology News(10 mins):FPC Introduces its Smallest Touch Fingerprint Sensors to Date 2LifeBEAM and Lazer Announce Expanded Partnership in Bio-Sensing Sports Gear 2LifeBEAM and Lazer Announce Expanded Partnership in Bio-Sensing Sports Gear 3NXT-ID, Inc.'s CTO, David Tunnell, Presents at CARTES SECURE CONNEXIONS AMERICA 2015 Today in Washington DC. 2NXT-ID, Inc.'s CTO, David Tunnell, Presents at CARTES SECURE CONNEXIONS AMERICA 2015 Today in Washington DC. 3
... Nine faculty members from The University of Texas at ... The University of Texas System Board of Regents for ... with a $25,000 cash award and recognize faculty members ... performance and innovation at the undergraduate level. The professors ...
... Schools of Medicine and Dentistry has received an award of ... Refinement and Reduction of Animals in Research (NC3Rs), for a ... of mouse cell which could be used in place of ... lung conditions. Macrophages are crucial components of the immune ...
... UCLA that conducts kidney tests and transmits data through ... frequent office visits by people with diabetes and others ... device was developed in the research lab of Aydogan ... the UCLA Henry Samueli School of Engineering and Applied ...
Cached Biology News:9 UT Arlington educators honored for teaching excellence 2Funding for animal testing alternative 2UCLA researchers invent portable device for common kidney tests 2
(Date:5/7/2015)... 2015 Kiadis   ... company developing innovative immunotherapy treatments, today announces the ... an independent member of its Supervisory Board. ... experience in the oncology and immunology field, including ... was Senior Vice-President and had responsibility for the ...
(Date:5/7/2015)... , May 7, 2015 ... pharmaceuticals company, today announces positive results from the ... hyperphosphataemia related to dialysis dependent chronic kidney disease ... by leading Cambridge -based scientists ... novel phosphate binder that is based on proprietary ...
(Date:5/6/2015)... , May 6, 2015 ... anzukündigen, dass das Unternehmen einen mehrjährigen Vertrag ... dem das Unternehmen exklusiv für den Vertrieb ... 2 S) konventionellen und organischen Wein- und ... tritt ab sofort in Kraft. ...
(Date:5/6/2015)... 6, 2015 Bone Biologics, Corp., ("Bone Biologics") announced ... Capital, LLC ("Hankey Capital") of Los Angeles, CA. ... use in bone regenerative medicine using the patented recombinant human ... undergoing spinal fusion. Michael Schuler , ... completion of this round of funding which will allow the ...
Breaking Biology Technology:Kiadis Pharma Appoints Dr. Vincent Brichard to its Supervisory Board 2Kiadis Pharma Appoints Dr. Vincent Brichard to its Supervisory Board 3Kiadis Pharma Appoints Dr. Vincent Brichard to its Supervisory Board 4Phosphate Therapeutics Announces Positive Results in the PEACH Pivotal Study of its Novel Phosphate Binder (PT20) for the Treatment of hyperphosphataemia 2Phosphate Therapeutics Announces Positive Results in the PEACH Pivotal Study of its Novel Phosphate Binder (PT20) for the Treatment of hyperphosphataemia 3Renaissance Yeast Inc. ernennt Quercus Europe, S.L. zum exklusiven Fachhändler für Schwefelwasserstoff-vermeidende Wein- und Mosthefen in Spanien 2Bone Biologics Corp Completes Financing With Hankey Capital, LLC 2Bone Biologics Corp Completes Financing With Hankey Capital, LLC 3
... SUNNYVALE, Calif., Sept. 14 Pharmacyclics, Inc. (Nasdaq: ... innovative small molecule drugs for the treatment of immune mediated ... results for the fourth quarter and fiscal year ended June ... 17, 2009 at 1:30 p.m. PDT (4:30 p.m. EDT). To ...
... , , JOHNSON CITY, Tenn., ... a potent radioprotectant as well as radiomitigator, protects against lethal, whole-body ... exposure. , , In recent experiments, the ... dose at either 48 or 72 hours after lethal, whole-body gamma ...
... , ... To achieve high levels of protein expression, many researchers have abandoned cloning in ... at a reasonable cost. Unlike a natural gene, a synthetic gene can be ... potential to be a huge advantage, as most researchers have come to accept ...
Cached Biology Technology:Pharmacyclics Announces Date of Fourth Quarter and Fiscal Year End 2009 Conference Call 2Rx100 Rescues Life if Administered Up to 72 Hours After Exposure to Lethal, Whole-Body Radiation! 2DNA2.0 Unlocks The Secrets Of Optimized Gene Design: Company Identifies Codon Choice Design Principles for Optimal Protein Expression 2DNA2.0 Unlocks The Secrets Of Optimized Gene Design: Company Identifies Codon Choice Design Principles for Optimal Protein Expression 3DNA2.0 Unlocks The Secrets Of Optimized Gene Design: Company Identifies Codon Choice Design Principles for Optimal Protein Expression 4
... Novel Object Records behavior directed toward examining ... line is a family of instruments all built ... extraction software and that can track two fields ... Software automatically extracts animal positions and records ...
... Magnetofection technology, SilenceMag is the most ... rapid and easy to use, SilenceMag ... Specifically designed for siRNA delivery, SilenceMag ... low doses of siRNA.,SilenceMag formulation gives ...
... technology, SilenceMag is the most efficient ... and easy to use, SilenceMag is ... designed for siRNA delivery, SilenceMag allows ... doses of siRNA.,SilenceMag formulation gives reliable ...
... O 2 S 2 Formula ... crystalline powder Assay: greater than or ... Melting Point: greater than or equal ... or equal to 1% Storage: ...
Biology Products: