Navigation Links
Getting to the heart of the heart

n, which lit up when a gene called Nkx2.5 was activated. Orkin and Wu then showed that these cells further differentiated into both myocardial cells and smooth-muscle cells.

Next, using the same fluorescent "tags," Orkin and Wu isolated the same cardiac progenitor cells directly from live mice early in embryonic development.

"There have been a number of publications about stem-like cells in the heart, but these are the first studies to identify such cells during embryonic development, and to show that they give rise to different cell types," says Orkin, who is the David G. Nathan Professor of Pediatrics at Harvard Medical School and also chairs the department of pediatric oncology at Dana-Farber Cancer Institute. He and Wu are also members of the Harvard Stem Cell Institute.

"Previously, it had been thought that each cell type in the heart had a different origin. Now, it's pretty clear that some have common origins," Orkin adds. "This changes the notion of how the heart develops. Instead of multiple different cell types migrating and coming together to form the heart, the heart comes from stem cells that give rise to multiple cell types in the same local environment ?a simpler way of building the organ. And because these cells can make multiple cell types, they could be more useful in repairing the heart than any single kind of cell."

Orkin cautions that there are many steps before cardiac progenitor cells could be used to repair a human heart. The studies were done in mice, and it's still unknown what factors make embryonic stem cells differentiate into cardiac progenitors, or what factors make cardiac progenitors differentiate into more specialized heart cells. But ultimately, cardiac surgeons at Children's hope to be able to use cardiac stem cells to repair congenital heart defects such as defective heart valves, missing or undeveloped arteries, or underdeveloped heart chambers.

"If you understand the process of how
'"/>

Source:Children's Hospital Boston


Page: 1 2 3

Related biology news :

1. Getting close to nature is good for you
2. Getting an evolutionary handle on life after reproduction
3. Getting old? Slowing down? Blame inefficient mitochondria
4. UCSD team discovers specialized, rare heart stem cells in newborns
5. Single stem cells from bone heal a broken heart
6. Python a hearty eater
7. Columbia study shows widely used artery clearing device does not help patients during heart attack
8. Researchers reveal secret of key protein in brain and heart function
9. Stem cell therapy successfully treats heart attack in animals
10. New defibrillator signals doctor of patients irregular heartbeat or device malfunction
11. Survival of heart patients on beta-blockers varies greatly with genetic variation
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Getting the heart the heart

(Date:7/31/2015)... 2015 Den 10. internationale konference om Genomik ... 22. - 25. oktober i Shenzhen ... fødselsdag i år. Siden starten i 2006 er ICB ... ,omik,-feltet, og er en af de mest dynamiske, entusiastiske ... på nylige gennembrud og fremskridt inden for ,omik,-forskning, som ...
(Date:7/31/2015)... 31 de julho de 2015 A 10 ... ) será realizada pela BGI de 22-25 de outubro de ... A conferência está celebrando seu 10 o. ... ICG se tornou uma das reuniões mais influentes do ... científicos mais dinâmicos, entusiastas e prazerosos. ...
(Date:7/31/2015)... de julio de 2015 La 10 th ... por medio de BGI del 22 al 25 de octubre de ... Este año, la conferencia celebra su décimo aniversario. Desde ... en una de las reuniones anuales más influyentes del mundo ... reuniones más dinámicas, entusiastas y mejores a nivel científico. ...
Breaking Biology News(10 mins):Den 10. internationale konference om Genomics (ICG-10) åbner i oktober 2A 10a. Conferência Internacional sobre Genômica (ICG-10) será em outubro 2A 10a. Conferência Internacional sobre Genômica (ICG-10) será em outubro 3La 10th International Conference on Genomics (ICG-10) se llevará a cabo en octubre 2La 10th International Conference on Genomics (ICG-10) se llevará a cabo en octubre 3
... Scientists believe they have found an explanation for a ... , Researchers at Washington University School of Medicine in ... Nile virus can enter a nerve cell, replicate and ... traveling this infectious pathway can break into the central ...
... all its forms, but not all water in our life systems ... a cup of tea is different from the water in our ... have a complete understanding as to why intracellular water is different ... conflicting theories. The very structure of water, as an open system ...
... are wildly unfavorable environments. Struggling for oxygen and ... systems, tumor cells in fact require sophisticated adaptations ... sought ways to circumvent these adaptations to destroy ... Medical School (UMMS), have defined a method to ...
Cached Biology News:West Nile virus' spread through nerve cells linked to serious complication 2West Nile virus' spread through nerve cells linked to serious complication 3Let's talk -- new paradigms in the research of the biomolecular composition of water 2Sidestepping cancer's chaperone 2
(Date:8/3/2015)... , Aug. 3, 2015  MiMedx Group, Inc. ... utilizing human amniotic tissue and patent-protected processes to develop ... Care, Surgical, Orthopedic, Spine, Sports Medicine, Ophthalmic and Dental ... at the 35 th Annual Canaccord|Genuity Growth Conference ... "Pete" Petit, Chairman and CEO, William C. Taylor ...
(Date:8/3/2015)... ... August 03, 2015 , ... Nine field days to promote practices ... Hosted by the Soil Health Partnership , the field days will demonstrate how ... potentially increasing farm productivity and income. , Brent Bible has practiced no-till farming and ...
(Date:8/3/2015)... Md. , Aug. 3, 2015   Intrexon ... will release first half and second quarter 2015 financial ... th , 2015.  The Company will host a conference ... and provide a general business update. The ... US) and 1-412-902-4262 (International), and asking to join the ...
(Date:8/3/2015)... WA (PRWEB) , ... August 03, 2015 , ... ... and TLD5000 diaphragm vacuum pumps to its comprehensive line of analytical laboratory equipment. ... steel valves, these versatile pumps provide a chemically resistant and maintenance-free solution for ...
Breaking Biology Technology:MiMedx To Present At 35th Annual Canaccord|Genuity Growth Conference 2Soil Health Field Days Kick Off Throughout Midwest 2Soil Health Field Days Kick Off Throughout Midwest 3Intrexon to Announce First Half and Second Quarter 2015 Financial Results and Host Conference Call on August 10th 2Sterlitech Launches New Line of Vacuum Pumps 2
... Genzyme Corp. said on Wednesday it has agreed ... Wisconsin-Madison biotech spinoff, for $600 million in cash. , ,Bone ... more than $2 billion and almost 7,000 employees worldwide, plan ... companies recently reported healthy quarterly profits and revenues. Bone Care ...
... a new copy machine for $57,000. , ,The Z-Corp ... typical office copier: It makes three-dimensional models of small structures ... , ,Using white polymer powder and colored inks, the printer ... a time. Z-Corp is headquartered in Burlington, Massachusetts. , , ...
... can submit executive summaries of their businesses for angel ... May 9. , ,The Wisconsin Angel Network ... investor networks with entrepreneurs based on the investors' market ... a deal-flow pipeline, has been designed to be a ...
Cached Biology Technology:Massachusetts firm to buy UW spinoff Bone Care for $600 million 2Massachusetts firm to buy UW spinoff Bone Care for $600 million 3Start-ups, angels can connect on new state Web site 2Start-ups, angels can connect on new state Web site 3
... anti-freeze environment for enzyme conjugated antibodies and ... viscosity solution at -20C , No ... is convenient , Contains preservatives to ... Protect enzyme conjugates during storage without the ...
A collection of 42 spots with normal tissues from different organs of C57 mice, rat and human....
... voice-coil scanning and positioning system is ... have to be positioned or scanned ... It provides superior responsiveness compared to ... mechanics (X or XY stage) are ...
Improves spot morphology and DNA binding to the slide resulting in increased hybridization signal. ID Clarifier: Optimized spotting solution for use with SigmaScreen APS Coated Slides for Microarrays...
Biology Products: