Navigation Links
Getting old? Slowing down? Blame inefficient mitochondria

Mitochondria are the cell's equivalent of power stations. A power station burns fuel to build up steam pressure and uses that pressure to drive a turbine linked to a dynamo. This in turn generates electricity. In mitochondria, the fuel is oxidised and builds up a pressure of hydrogen ions (protons). These force through molecular turbines and enable the cell to generate ATP, an energy unit that can be used throughout the cell.

Just as you can work out a power station's efficiency by seeing how much electricity it produces for each unit of oxygen and fuel it burns, you can assess the efficiency of mitochondria by monitoring the amount of ATP produced for every unit of oxygen used.

Researchers from various departments of the University of Washington, Seattle, compared resting muscle cells from young (7-month) and old (30-month) mice. They found that old muscle used around half as much energy as young muscle, but that the mitochondria used just as much oxygen at both ages. This represents a 50% loss in efficiency.

"The best explanation for this loss of efficiency is that the mitochondria become leaky as they get old. Protons leak back into the mitochondria without making ATP, and so reduce the coupling between oxygen use and ATP production," says lead author David Marcinek, who works in the department of radiology.

This inefficiency means that elderly people's muscle produce less useable energy (ATP) for every unit of oxygen consumed, making normal activity seem more challenging and limiting their range of activities.


Source:Blackwell Publishing Ltd.

Page: 1

Related biology news :

1. Getting close to nature is good for you
2. Getting an evolutionary handle on life after reproduction
3. Getting to the heart of the heart
4. Slowing the racing heart
5. Blame the brain for high blood pressure
6. Computational model simulates AZT metabolism in mitochondria
7. Protein sensor for fatty acid buildup in mitochondria
Post Your Comments:

(Date:3/29/2017)... -- higi, the health IT company that operates the largest ... , today announced a Series B investment from BlueCross ... new investment and acquisition accelerates higi,s strategy to create ... health activities through the collection and workflow integration of ... and secures data today on behalf of over 36 ...
(Date:3/24/2017)... Controller General of Immigration from Maldives Mr. Mohamed Anwar and ... international IAIR Award for the most innovative high security ePassport and eGates  ... ... Maldives Immigration Controller General, Mr. Mohamed Anwar ... right) have received the IAIR award for the "Most innovative high security ...
(Date:3/23/2017)... Research and Markets has announced the addition of the ... Forecast to 2025" report to their offering. ... The Global Vehicle Anti-Theft System ... over the next decade to reach approximately $14.21 billion by 2025. ... forecasts for all the given segments on global as well as ...
Breaking Biology News(10 mins):
(Date:10/12/2017)... ... 2017 , ... BioMedGPS announces expanded coverage of SmartTRAK Business ... US Hemostats & Sealants. , SmartTRAK’s US Market for Hemostats and Sealants module ... and biologic sealants used in surgical applications. BioMedGPS estimates the market will grow ...
(Date:10/11/2017)... ... ... eye wash is a basic first aid supply for any work environment, but most personal ... rinse first if a dangerous substance enters both eyes? It’s one less decision, and likely ... dual eye piece. , “Whether its dirt and debris, or an acid or alkali, getting ...
(Date:10/11/2017)... ... 11, 2017 , ... Disappearing forests and increased emissions are the main causes ... each year. Especially those living in larger cities are affected by air pollution related ... the most pollution-affected countries globally - decided to take action. , “I knew I ...
(Date:10/10/2017)... ... October 10, 2017 , ... ... program has won a US2020 STEM Mentoring Award. Representatives of the FirstHand program ... in Volunteer Experience from US2020. , US2020’s mission is to change the trajectory ...
Breaking Biology Technology: