Navigation Links
Genrate: a generative model that finds and scores new genes and exons in genomic microarray data

Abstract : Recently, researchers have made some progress in using microarrays to validate predicted exons in genome sequence and find new gene structures. However, current methods rely on separately making threshold-based decisions on intensity of expression, similarity of expression profiles, and arrangements of exons in the genome.

We have taken a Bayesian approach and developed GenRate, a generative model that accounts for both genome-wide expression data taken from multiple conditions (e.g. tissues) and co-location and density of probes in DNA sequence data.

GenRate balances probabilistic evidence derived from different sources and outputs scores (log-likelihoods) for each gene model, enabling the estimation of false-positive and false-negative rates. The model has a number of local minima that is exponential in the length of the DNA sequence data, so direct application of the EM learning algorithm produces poor results. We describe a novel way of parameterizing the model using examples from the data set, so that good solutions are found using an efficient algorithm. We apply GenRate to a subset of mouse genome-wide expression data that we have created, and discuss the statistical significance of the genes found by GenRate. Three of the highest-ranking gene structures found by GenRate, each containing thousands of bases from the genome, are confirmed using RT-PCR experiments.


'"/>

Source:PubMed


Page: 1

Related biology news :

1. Pinpointing the cause of a neurodegenerative disorder
2. Study ties new cell-death mechanism to developmental and degenerative brain disorders
3. Sticky mice lead to discovery of new cause of neurodegenerative disease
4. Nanotechnology propels advances in regenerative medicine research
5. Moonlighting enzyme linked to neurodegenerative disease
6. Stanford scientists make major breakthrough in regenerative medicine
7. Stem cells act through multiple mechanisms to benefit mice with neurodegenerative disease
8. Scientists identify new model Of NK cell development
9. Molecular models advance the fight against malaria
10. NYU and MSKCC research provides model for understanding chemically induced cancer initiation
11. Genetic therapy reverses nervous system damage in animal model of inherited human disease
Post Your Comments:
(Date:4/2/2015)... -- Fingerprint Cards (FPC) has received an ... distributor World Peace Industrial Group (WPI), part of WPG ... major part of the shipments will take place during ... manufacturers in China . The order ... revenue guidance of + 1 000 MSEK for 2015.  ...
(Date:3/31/2015)... , March 31, 2015   Guidepoint , a ... of the Post-Surgical Pain Management TRACKER, part of the ... usage trends in the medical device and therapeutics markets. ... data including treatment volumes, market share, and adoption rates ... associated with joint surgery. The Post-Surgical Pain ...
(Date:3/24/2015)... 24, 2015 Research and Markets ( http://www.researchandmarkets.com/research/kvdtcw/face_and_voice ) ... - Global Strategic Business Report" report to their offering. ... Biometrics in US$ Thousands by the following Segments: Face Biometrics, and ... Canada , Japan , ... Middle East & Africa , and ...
Breaking Biology News(10 mins):Fingerprint Cards Receives Touch Fingerprint Sensor Order of SEK 110 Million 2Guidepoint Launches Post-Surgical Pain Management TRACKER 2Guidepoint Launches Post-Surgical Pain Management TRACKER 3Face and Voice Biometrics - Global Strategic Business Report 2015: Face Recognition Gains Prominence in Immigration Control 2Face and Voice Biometrics - Global Strategic Business Report 2015: Face Recognition Gains Prominence in Immigration Control 3Face and Voice Biometrics - Global Strategic Business Report 2015: Face Recognition Gains Prominence in Immigration Control 4Face and Voice Biometrics - Global Strategic Business Report 2015: Face Recognition Gains Prominence in Immigration Control 5Face and Voice Biometrics - Global Strategic Business Report 2015: Face Recognition Gains Prominence in Immigration Control 6
... research findings suggest that an experimental ultrasensitive medical imaging ... "nanocages" might enable both the early detection and treatment ... laser pulses through the skin to detect hollow nanocages ... gold and silver - that are injected into the ...
... JOLLA, CA April 12, 2010 Scientists at The ... human embryonic stem cells are so difficult to culture in ... the field closer to the day when stem cells can ... being published in the journal Proceedings of the National ...
... OHIO -- April 12, 2010 For millions of Americans ... onset typically in adulthood) the associated risk of cancer is ... excess insulin whether naturally produced by the body or ... incidence of some common cancers. With the ...
Cached Biology News:Ultrasensitive imaging method uses gold-silver 'nanocages' 2Scripps Research scientists solve mystery of fragile stem cells 2Scripps Research scientists solve mystery of fragile stem cells 3Case Western Reserve team discovers 'smart' insulin molecule 2
(Date:4/24/2015)... 2015 /PRNewswire/ - BioAmber Inc. (NYSE: BIOA ) ... supplier of bio-succinic acid used to produce a ... applications that Bayer MaterialScience has begun commercializing.    ... eco, a series of bio-based waterborne polyurethane ... as 65%.  IMPRANIL ® eco has been ...
(Date:4/24/2015)... -- Navitas Life Sciences is delighted to announce the appointment of ... Services. Shalabh is a proven leader in Life Science consulting ... as well as a Strategy consultant at Accenture. ... ... to welcome Shalabh into this critical role and also as ...
(Date:4/23/2015)... Marshall, MN (PRWEB) April 24, 2015 ... agreement with Advanced Birthright Nutrition® (ABN) for the exclusive ... Milk Cup. The new technology is a new in-line ... swine producers by allowing them to move supplementation milk ... running. , “This technology lets producers get ...
(Date:4/23/2015)... MISSISSAUGA, ON , April 23, 2015 /CNW/ ... major sustainable packaging award from North ... Packaging,s Brandcheck Competitor Comparison won Silver in the ... Awards. The Brandcheck "Competitor Comparison" is ... set of North American and Global peers. This ...
Breaking Biology Technology:Bayer MaterialScience Names BioAmber As Its Supplier For New Product Line - Bio-succinic acid forms backbone of innovative new bio-based polyurethanes for textiles 2Bayer MaterialScience Names BioAmber As Its Supplier For New Product Line - Bio-succinic acid forms backbone of innovative new bio-based polyurethanes for textiles 3Bayer MaterialScience Names BioAmber As Its Supplier For New Product Line - Bio-succinic acid forms backbone of innovative new bio-based polyurethanes for textiles 4Shalabh Kumar Joins Navitas Life Sciences to Lead their Clinical and Regulatory Services Teams 2Ralco Acquires License to Birthright™ Moveable Milk Cup 2
... CASTRES, France , July 2, 2010 ... Officer at Pierre Fabre,Group starting September 1, 2010 . , ... Until now, Olivier Bohuon ... division. As such, he ran the,group,s entire pharmaceutical activities from Chicago ...
... starts from a roll of flexible foil onto which the ... finally rolled up onto the coil again. Encapsulated and ready-to-use ... to the customer,s specification. As the whole process from feedstock ... paves the way towards mass production of solar cells and ...
... BELGRADE, Mont. , July 1 ... developer of anti-infective coatings for medical applications and revolutionary ... the appointment of three seasoned financial experts to its ... R. Frank whose asset management experience spans 31 ...
Cached Biology Technology:Olivier Bohuon Joins Pierre Fabre 2Mass production of polymer solar cells is within reach 2Bacterin International Appoints Three New Members to Its Board of Directors 2Bacterin International Appoints Three New Members to Its Board of Directors 3Bacterin International Appoints Three New Members to Its Board of Directors 4
RABBIT ANTI HUMAN CYTOCHROME P450 1A1/2 Immunogen: Purified human CYP1A2 expressed in E.Coli ...
... cloning of BAC (100+kb), fosmid (40kb), and ... stability than any othe BAC vector. On ... yields and easy recombinant DNA purification. Available ... (pSMART VC) vectors for the highest insert ...
... Error-free cloning of BAC (100+kb), fosmid ... Greater insert stability than any othe BAC ... for high yields and easy recombinant DNA ... or transcription-free (pSMART VC) vectors for the ...
RABBIT ANTI GLYCINE...
Biology Products: