( I the research team included scientist...)Genomics-based vaccine could prevent deadly cattle disease

I, the research team included scientists from: the Ludwig Institute for Cancer Research in Brussels; the Wellcome Trust Center for Human Genetics in Oxford; Sanofi Pasteur in Toronto; the University of Edinburgh; and Merial SAS, an international animal health company. ILRI and Merial have partnered to develop a vaccine against East Coast fever.

By using genomics to understand and fight T. parva, scientists may make advances against related parasites that cause malaria, tuberculosis, and other diseases in which killer T cells also play a role in immunity. What's more, because T. parva launches a cancer-like illness inside the white blood cells of cattle, it may provide a model system for understanding the mechanics of cancer biology.

But for Nene, who was born in Kenya and worked at ILRI for 15 years before coming to TIGR in 2001, the march against East Coast fever is significant reward, itself. "This disease takes an enormous toll on the local society and economy of rural areas across eastern and central Africa, including Maasai and other pastoral communities," he says.

In particular, East Coast fever kills cattle kept by families trying to rise out of poverty. If researchers are successful, Nene notes, the entire region will have new reason to hope for a better life. Evans Taracha, ILRI project leader, also highlights the importance of strategic research partnerships to overcome this and similar diseases.

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Source:The Institute for Genomic Research


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