Navigation Links
Genomic comparison of lactic acid bacteria published

With public concerns at a fevered pitch over the bacterial contamination of spinach, it is easy to lose track of how bland and deprived our world would be without the contribution to our food supply of such benign microbial players as lactic acid-producing bacteria. Researchers from the U.S. Department of Energy Joint Genome Institute (DOE JGI) and the University of California, Davis, and their colleagues have characterized the genome sequences of nine different lactic acid-producing bacteria, or LAB, and have published their findings in the October 17 edition of the Proceedings of the National Academy of Sciences (http://www.pnas.org/cgi/content/abstract/0607117103v1). The small LAB genomes encode a diverse repertoire of genes for efficient carbon and nitrogen acquisition from the nutritionally rich environments they inhabit and reflect a limited range of biosynthetic capabilities promising broad industrial applications.

Lactic acid-producing bacteria play a key role in the production of fermented foods and beverages, accounting for tens of billions of dollars in sales annually. Products constituting a fine repast, such as wine, salami, cheese, sourdough bread, pickles, yogurt, cocoa, and coffee are all enhanced by LAB, which ferment six-carbon sugars, or hexoses, to produce lactic acid.

"DOE JGI's contribution to the whole study of lactic acid bacteria is simply immense," said David Mills, Associate Professor, Viticulture & Enology, University of California, Davis, and senior author on the study. "Access to the genome sequences for these fermentative microorganisms will dramatically increase our understanding of their role in industrial food production, leading to more optimized production schemes. For example, a better understanding of the role of lactic acid bacteria in cheese ripening will result in production strategies that reduce ripening time and thereby save energy. Moreover, lactic acid bacteria are used for production of various commercial bioproducts such as dextran and antimicrobials. The availability of these genome sequences will foster development of additional production schemes for biofuels and other important chemicals."

The publication is the culmination of a multiyear effort by the Lactic Acid Bacteria Genome Consortium, a group of at least a dozen academic organizations formed in 2001. Paul Richardson, DOE JGI Genomic Technologies Program head, said that the functional classification embraced a variety of industrially important genera, including Lactococcus, Enterococcus, Oenococcus, Pediococcus, Streptococcus, Leuconostoc, and Lactobacillus species. "The sequence of these diverse species offered a window into the sugar metabolism and energy conversion systems of LAB, and the evolution of these systems, which helped identify key enzymes involved in the production of end products including acetic acid, lactic acid, ethanol, and CO2."

"This work represents a hallmark in the genomic and bioinformatic characterization of lactic acid bacteria that have an impact on food, health, and agriculture," said Willem M. de Vos, Professor of Microbiology and Program Director of the Wageningen Center for Food Sciences in Holland. "In a heroic effort, their publication more than doubles the number of lactic acid bacterial genomes that are publicly available and provides the research community with a wealth of high-quality data that can be used to understand and improve starter cultures for dairy, meat, and wine fermentations; probiotic cultures; and other industrial applications. The extensive bioinformatic analyses by world experts adds to the impact of the genomic data and provides new hypotheses on how microbial genomes evolve by mechanisms of genomic loss and horizontal gene acquisitions."


'"/>

Source:DOE/Joint Genome Institute


Related biology news :

1. Advancements In Genomics Foster Deep Sea Discoveries
2. Ariadne Genomics Announces the Release of PathwayStudio?Central, Client-Server Software for Biological Pathway Analysis
3. Genomic sequences processed in minutes, rather than weeks
4. Agilent Technologies Introduces First Commercial Mouse Microarray for Comparative Genomic Hybridization Research
5. Genomics researchers discover protein deficit that causes drug toxicity
6. Genomics-based vaccine could prevent deadly cattle disease
7. Genomics throws species definition in question for microbes
8. Multi-species genome comparison sheds new light on evolutionary processes, cancer mutations
9. Wild vs. lab rodent comparison supports hygiene hypothesis
10. Anti-bacterial additive widespread in U.S. waterways
11. A bacterial genome reveals new targets to combat infectious disease
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/7/2017)... 7, 2017   MedNet Solutions , an innovative ... of clinical research, is pleased to announce that the ... innovative, highly flexible and award winning eClinical solution, is ... iMedNet is a proven Software-as-a-Service (SaaS) clinical research ... (EDC), but also delivers an entire suite of eClinical ...
(Date:2/6/2017)... Feb. 6, 2017 According to Acuity ... driving border authorities to continue to embrace biometric ... are 2143 Automated Border Control (ABC) eGates and ... at more than 163 ports of entry across ... 2016 achieving a combined CAGR of 37%. APC ...
(Date:2/2/2017)... , Feb. 2, 2017   TapImmune, ... clinical-stage immuno-oncology company specializing in the development of ... the treatment of cancer and metastatic disease, announced ... and GMP manufacturing of a second clinical lot ... targeting folate receptor alpha. The manufactured vaccine product ...
Breaking Biology News(10 mins):
(Date:2/18/2017)... , Feb 17, 2017 Research and ... Strategic Business Report" report to their offering. ... The report provides separate comprehensive ... Europe , and Rest of World. Annual estimates and forecasts ... historic analysis is provided for these markets. Market data and analytics ...
(Date:2/17/2017)...  If only one in every hundred cells ... to chemotherapy, thousands of cancer cells would remain ... finding these mutations in ever-smaller subpopulations of tumor ... in blood — to guide treatment decisions and ... however, detecting these genetic anomalies may be more ...
(Date:2/16/2017)... ... February 16, 2017 , ... EIT Digital has ... at the agricultural industry. Pilot studies are about to get under way for the ... Data and 5G innovations. The concept is expected to be transferred eventually to other ...
(Date:2/16/2017)... GREENWICH, Conn. , Feb. 16, ... focused on venture growth investments in biotechnology and ... Josh Richardson , M.D. to Managing Director. ... companies.  He is a board observer at InfaCare ... Longitude,s investments in Aimmune Therapeutics, Akebia Therapeutics, Cadence ...
Breaking Biology Technology: