Navigation Links
Genome of deadly amoeba shows surprising complexity, evidence of lateral gene transfer

The genome sequence of the parasitic amoeba Entamoeba histolytica, a leading cause of severe diarrheal disease in developing countries, includes an unexpectedly complex repertoire of sensory genes as well as a variety of bacterial-like genes that contribute to the organism's unique biology.

The report, which appears in the February 24 issue of Nature, presents the first genome-wide study of an amoeba. It is also the first genome sequence to be published from this class of amitochondrial human pathogens.

The analysis reveals the degradation of the E. histolytica genome in its transition from a free-living organism into a parasite of the human gut. At the same time, scientists also cataloged the retention and expansion of some gene families characteristic of more complex organisms.

Detailing the first systematic study of relatively recent horizontal gene transfer into a protist, scientists report evidence in the DNA sequence that E. histolytica likely picked up a significant number of its metabolic genes from bacterial co-inhabitants of the human gut. Identification of these genes sheds new light on the unusual shared biology between the parasitic amoeba and anaerobic gut bacteria.

The E. histolytica genome sequence is expected to help in the development of new vaccines as well as diagnostic tests that can distinguish the amoeba's most deadly strains. The parasite infects an estimated 50 million people and causes as many as 100,000 deaths a year -- second only to malaria as a cause of morbidity and mortality from a protist. The disease caused by E. histolytica is called amebiasis.

The sequencing of E. histolytica was a collaborative effort led by The Institute for Genomic Research (TIGR) in Rockville, MD, and by the Wellcome Trust Sanger Institute in the U.K. The project was supported by grants from the National Institute of Allergy and Infectious Diseases (NIAID), which is part of the National Institutes of Health, and from the
'"/>

Source:The Institute for Genomic Research


Page: 1 2 3 4 5

Related biology news :

1. Affymetrix Unveils Plans to Double Plant and Animal Genome Microarray Offering
2. Genome-wide mouse study yields link to human leukemia
3. New Study from Affymetrix Laboratories Points to Changing View of How Genome Works
4. Multiple Campylobacter Genomes Sequenced
5. Analysis Of Human Genome To Predict The Development Of Illnesses
6. Whole genome promoter mapping - Human Genome Project v2.0?
7. Genome study of beneficial microbe may help boost plant health
8. Candida albicans Genome Fully Annotated
9. Genome Sequence for Haemophilus Influenzae Completed
10. NHGRI Selects 13 More Organisms for Genome Sequencing
11. First Whole Genome Map of Genetic Variability in Parkinson’s Disease
Post Your Comments:
(Date:12/10/2014)... California , December 9, 2014 ... with ITN,s BCARD Platform   ... cloud-based enterprise meeting scheduling solutions for business-to-business (B2B) ... the world leader in mobile near-field communication (NFC), ...      (Logo: http://photos.prnewswire.com/prnh/20140612/691055) , ...
(Date:12/4/2014)... PALM BEACH GARDENS, Fla. , Dec. 3, ... identity management solutions, today announced that its DigitalPersona ... 4500 fingerprint readers have been deployed throughout ... Carolina , South Carolina ... network headquartered in Southern Pines, North ...
(Date:11/21/2014)... According to a new market research report ... Control, Intrusion Detection, Parking Management, Under Vehicle Inspection), End ... - Global Forecasts to 2020", published by MarketsandMarkets, The ... $25 Billion in 2014 and is expected to reach ... 8.69%. Browse 116 market data Tables and ...
Breaking Biology News(10 mins):Jifflenow And ITN International Bring Cutting-Edge Badge Scanning Technology To B2B Events 2Jifflenow And ITN International Bring Cutting-Edge Badge Scanning Technology To B2B Events 3First Bank Partners with Crossmatch to Increase Log In Security 2First Bank Partners with Crossmatch to Increase Log In Security 3Industrial Security Systems Market Worth $38 Billion by 2020 2Industrial Security Systems Market Worth $38 Billion by 2020 3
... This news release is available in German . ... is made up of a highly concentrated protein solution that imparts ... content the ocular lens must remain clear and transparent. To this ... thrown overboard the complex machinery present in all other cells of ...
... study led by scientists at the University of Miami (UM) ... complex circulation from the Mississippi River plume played a substantial ... the 2010 Deepwater Horizon incident. These findings provide new information ... Gulf of Mexico. The research, published in the Oct. 2013 ...
... use in vaccines and cancer medicines, enzymes for the ... already be produced on a large scale using biotechnology. ... making use of living cells or organisms. This involves ... protein to bacteria, yeasts, or cultures of animal or ...
Cached Biology News:A protein safeguards against cataracts 2A protein safeguards against cataracts 3New research illustrates Mississippi River's role 2Biomolecules for the production line 2Biomolecules for the production line 3
(Date:12/19/2014)... , Dec. 18, 2014  Decision Resources Group ... dental biomaterial market will grow moderately through 2023 as ... and growing awareness of dental biomaterials all spur procedure ... such as China and ... bring dental procedures within reach for a larger proportion ...
(Date:12/19/2014)... YORK , Dec. 18, 2014 Relmada ... therapies for the treatment of chronic pain, announced the ... today. "This was a transformational year in ... promising future for our company," said Sergio Traversa ... year, we have executed on key financial, human resource ...
(Date:12/17/2014)... “Never say, ‘I cannot do ... Department of Physics, advises young women pursuing careers ... SPIE Women in Optics 18-month planner ... ask questions.” , In the annual planner, women ... ranging from university professor and laboratory researcher to ...
(Date:12/17/2014)... CA (PRWEB) December 17, 2014 Once ... to provide a larger packaged waste water treatment plant ... King Abdullah Economic City (KAEC). Two years ago Bioshaft ... Jeddah Gate Development, serving two residential towers with an ... is over a quarter million gallons per day and ...
Breaking Biology Technology:Asia Pacific Dental Biomaterial Market Will Grow Strongly Through 2023 2Asia Pacific Dental Biomaterial Market Will Grow Strongly Through 2023 3Relmada Therapeutics Announces Results of Annual Shareholders Meeting 2Network, Multitask, Persevere: SPIE Women in Optics Planner Subjects Share from Experience 2Network, Multitask, Persevere: SPIE Women in Optics Planner Subjects Share from Experience 3
... , ... that the European Investment Fund (EIF) has entered into ... be,managed by Karolinska Development and used to invest in ... EIF,has agreed to invest 26.7 M Euros in the ...
... ... a free webinar, “The Role of Process Analytical Technology (PAT) in Green Chemistry and ... ... of Process Analytical Technology (PAT) in Green Chemistry and Green Engineering Webinar on ...
... SEATTLE, Nov. 19 Omeros Corporation (Nasdaq: OMER ) today ... 2009. For the three months ended September 30, 2009, Omeros reported ... compared to a net loss of $7.4 million, or $2.54 per ... ended September 30, 2009, the Company reported a net loss of ...
Cached Biology Technology:Karolinska Development and EIF Start Landmark Co-Investment Fund for Life Science Innovation 2Karolinska Development and EIF Start Landmark Co-Investment Fund for Life Science Innovation 3Process Analytical Technology (PAT) in Green Chemistry and Green Engineering 2Omeros Corporation Reports Third Quarter 2009 Financial Results and Development Highlights 2Omeros Corporation Reports Third Quarter 2009 Financial Results and Development Highlights 3Omeros Corporation Reports Third Quarter 2009 Financial Results and Development Highlights 4Omeros Corporation Reports Third Quarter 2009 Financial Results and Development Highlights 5Omeros Corporation Reports Third Quarter 2009 Financial Results and Development Highlights 6Omeros Corporation Reports Third Quarter 2009 Financial Results and Development Highlights 7Omeros Corporation Reports Third Quarter 2009 Financial Results and Development Highlights 8
... a small and sensitive single quadrupole ... LC and IC. It features a newly ... (API) source for outstanding sensitivity and noise ... existing LC and IC methods, especially those ...
... The CHEMICON® CaspaTag™ Caspase-9 Pan-Caspase In Situ ... for detection of active caspases in cells ... use only. Not for use in diagnostic ... Caspase Detection Kits use a novel approach ...
... of Saccharomyces cerevisiae, as well as other ... many molecular biology laboratories. The ability to ... plasmid and linear DNAs using lithium based ... plasmid transformations and library screening easy and ...
... a fluorescein-conjugated jetSI-ENDO (excitation ... 520 nm), the powerful siRNA ... used to determine the transfection ... delivery and trafficking of siRNAs. ...
Biology Products: