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Genome of Clostridium botulinum reveals the background to world's deadliest toxin

of Applied Molecular Microbiology at The University of Nottingham, has developed new methods to knock out genes in clostridia.

"Even after decades of research, only a handful of mutants had been made in clostridia, and none in C. botulinum," Professor Minton explains. "We have developed a highly efficient system, the ClosTron, with which we have, in a few months, knocked out over 30 genes in four different clostridial species, including eight in C. botulinum. The availability of this tool should revolutionise functional genomic studies in clostridia."

This remarkable, stable genome demonstrates the wide range of strategies used by bacteria to enhance their chances of survival. For the Clostridia, these range from the approach used by Cdiff — long-term interaction with hosts, which involves evading the immune system and countering antibiotics — to the single-minded opportunistic approach of C. botulinum.
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Source:University of Nottingham


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