Navigation Links
Genomatix technology facilitates de novo identification of new renal disease associated genes

Previously unknown molecules and regulatory pathways in human glomerular diseases have been identified by a joint effort of the Medizinische Poliklinik, Munich, the University of BristolĀ“s ChildrenĀ“s Renal Unit, the German Cancer Research Center, sanofi-aventis, and Genomatix Software GmbH.

In a joint publication in the Proceedings of the National Academy of Sciences of the United States of America (PNAS) above groups show how new bioinformatics approaches allow rapid characterization of shared promoter structures which can be used to find novel interacting molecules. Here, these principles are applied to a set of genes linked to the unique functional unit of the glomerular slit diaphragm. An evolutionarily conserved promoter model was generated. Genome-wide scans using this promoter model effectively predicted a previously unrecognized slit diaphragm molecule which was then experimentally verified.

This publication shows a straightforward approach how comparative promoter analysis can identify regulatory pathways at work in tissue homeostasis and disease processes.


'"/>

Source:Genomatix Software GmbH


Page: 1

Related biology news :

1. Genomatix, AAAS ink agreement
2. Genomatix Microarray Analysis Pipeline achieves Affymetrix GeneChip compatible?status
3. MatBase -- A new transcription factor knowledge base released by Genomatix
4. Application of Genomatix in silico methods reveals novel cancer associated genes
5. Novel technology detects human DNA mutations
6. Novel antiviral technology inhibits RSV infection in mice
7. The BIOS Initiative - open source biotechnology is born
8. Revolutionary nanotechnology illuminates brain cells at work
9. Study: homemade gene expression technology unreliable
10. First technology to remove prions that cause vCJD from blood launched
11. Integration of Agilents MS technology, Proteome Systems software to help scientists in proteomics research
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/13/2017)... 2017  RSA Conference -- RSA, a Dell Technologies ... to enhance fraud detection and investigation across digital ... Fraud & Risk Intelligence Suite. The new platform ... insights from internal and external sources as well ... customers from targeted cybercrime attacks. "Fraudsters ...
(Date:2/9/2017)... Feb. 9, 2017 The biomass boiler market ... the biomass boiler market globally in terms of revenue ... boilers. The market for biomass boilers has been segmented ... application, and country/region. The market based on feedstock type, ... residues, biogas & energy crops, urban residues, and others. ...
(Date:2/8/2017)... , Feb. 7, 2017 Report Highlights ... The global ... reach $11.4 billion by 2021, growing at a compound annual ... - An overview of the global markets for synthetic biology. ... estimates for 2016, and projections of compound annual growth rates ...
Breaking Biology News(10 mins):
(Date:2/28/2017)... ... February 28, 2017 , ... ... of antibody therapeutics from millions-diverse immune repertoires, today announced a strategic partnership with ... strains genetically engineered to express human antibodies. The partnership will use GigaGen technology ...
(Date:2/28/2017)... , Feb. 28, 2017  ITL Limited ... company, supplier and strategic partner that provides innovative ... individual health management, formally announces its rebrand to ... name change is part of the Company,s unified ... launch of an integrated corporate website, ITLHealthGroup.com ...
(Date:2/28/2017)... and NEW YORK , February ... License Application accepted by the FDA for avelumab  ... disease has metastasized   ... Germany , in the US and ... US Food and Drug Administration (FDA) has accepted for Priority ...
(Date:2/27/2017)... -- A Europe-wide survey of institutes conducted by the ... their research treat them with due care. The survey polled a ... the results indicates that there is a strong commitment among animal ... the principles of the 3Rs (Refine, Reduce, Replace)  ... What are the 3Rs? ...
Breaking Biology Technology: