Navigation Links
Genomatix technology facilitates de novo identification of new renal disease associated genes

Previously unknown molecules and regulatory pathways in human glomerular diseases have been identified by a joint effort of the Medizinische Poliklinik, Munich, the University of BristolĀ“s ChildrenĀ“s Renal Unit, the German Cancer Research Center, sanofi-aventis, and Genomatix Software GmbH.

In a joint publication in the Proceedings of the National Academy of Sciences of the United States of America (PNAS) above groups show how new bioinformatics approaches allow rapid characterization of shared promoter structures which can be used to find novel interacting molecules. Here, these principles are applied to a set of genes linked to the unique functional unit of the glomerular slit diaphragm. An evolutionarily conserved promoter model was generated. Genome-wide scans using this promoter model effectively predicted a previously unrecognized slit diaphragm molecule which was then experimentally verified.

This publication shows a straightforward approach how comparative promoter analysis can identify regulatory pathways at work in tissue homeostasis and disease processes.


Source:Genomatix Software GmbH

Page: 1

Related biology news :

1. Genomatix, AAAS ink agreement
2. Genomatix Microarray Analysis Pipeline achieves Affymetrix GeneChip compatible?status
3. MatBase -- A new transcription factor knowledge base released by Genomatix
4. Application of Genomatix in silico methods reveals novel cancer associated genes
5. Novel technology detects human DNA mutations
6. Novel antiviral technology inhibits RSV infection in mice
7. The BIOS Initiative - open source biotechnology is born
8. Revolutionary nanotechnology illuminates brain cells at work
9. Study: homemade gene expression technology unreliable
10. First technology to remove prions that cause vCJD from blood launched
11. Integration of Agilents MS technology, Proteome Systems software to help scientists in proteomics research
Post Your Comments:

(Date:6/9/2016)... , June 9, 2016 ... deploy Teleste,s video security solution to ensure the safety of ... during the major tournament Teleste, an ... systems and services, announced today that its video security solution ... to back up public safety across the country. The ...
(Date:6/3/2016)... 2016 Das DOTM ... Nepal hat ein 44 Millionen ... Kennzeichen, einschließlich Personalisierung, Registrierung und IT-Infrastruktur, an ... und Implementierung von Identitätsmanagementlösungen. Zahlreiche renommierte internationale ... teilgenommen, aber Decatur wurde als konformste und ...
(Date:6/2/2016)... 2016   The Weather Company , an IBM Business ... industry-first capability in which consumers will be able to interact ... questions via voice or text and receive relevant information about ... Marketers have long sought an advertising solution that can ... personal, relevant and valuable; and can scale across millions of ...
Breaking Biology News(10 mins):
(Date:6/27/2016)... , June 27, 2016 /PRNewswire/ - BIOREM Inc. (TSX-V: ... been advised by its major shareholders, Clean Technology Fund ... United States based venture capital funds ... of Biorem (on a fully diluted, as converted basis), ... disposition of their entire equity holdings in Biorem to ...
(Date:6/27/2016)... ... June 27, 2016 , ... Cancer ... what they believe could be a new and helpful biomarker for malignant pleural ... Click here to read it now. , Biomarkers are components in the ...
(Date:6/27/2016)... ... June 27, 2016 , ... Newly ... technologies, services and solutions to the healthcare market. The company's primary focus is ... manufacturing, sales and marketing strategies that are necessary to help companies efficiently bring ...
(Date:6/27/2016)... 2016  Liquid Biotech USA ... a Sponsored Research Agreement with The University of ... from cancer patients.  The funding will be used ... with clinical outcomes in cancer patients undergoing a ... be employed to support the design of a ...
Breaking Biology Technology: