Navigation Links
Genetically modified natural killer immune cells attack, kill leukemia cells

lation of these immune cells.

The researchers then genetically modified the growing NK cells so they carried on their surface an artificial receptor that made them particularly aggressive and effective killers that attacked only leukemic cells. A receptor is a protein that binds to a specific target molecule. The artificial receptor on the NK molecule was designed to recognize a protein called CD19, which is found on the surface of leukemic cells. When the receptor bound to CD19 on leukemic cells, it set off a reaction that super-charged the killing activity of the NK cell.

"By developing a technique for cultivating large numbers of NK cells from a small blood sample, we made it practical to consider them a potential treatment against many different types of cancer," Campana said. "By genetically modifying NK cells so they expressed the CD19 receptor, we made them specifically effective against ALL cells."

A potential clinical application for the technology developed in this study is in leukemia patients who are treated with hematopoietic (blood cell-forming) cell transplantation. In this case, NK cells will be derived from the transplant donor, expanded and genetically modified. These modified NK cells will then be infused into the patient after the transplant in order to eliminate residual leukemic cells. In another application, NK cells could be obtained from a patient while in remission and then reinfused after genetic modification if the patient suffers a resurgence of the leukemia.

"We look forward to seeing this strategy being added to the management of children with ALL," said Chihaya Imai, M.D., the postdoctoral student who did most of the work on this project.


'"/>

Source:St. Jude Children's Research Hospital


Page: 1 2

Related biology news :

1. Genetically modified rice in China benefits farmers health, study finds
2. Genetically Modified Natural Killer Immune Cells Attack, Kill Leukemia Cells
3. Genetically engineered animals help in scientific research that may benefit children
4. Genetically modified maize not found in southern Mexico
5. Genetically engineered mosquitoes show resistance to dengue fever virus
6. Genetically altered mice no longer like cocaine
7. Genetically engineered blood protein can be used to split water into oxygen and hydrogen
8. Study finds that a womans chances of having twins can be modified by diet
9. UCSD discovery may help extend life of natural pesticide
10. Insight into natural cholesterol control suggests novel cholesterol-lowering therapy
11. UCLA scientists store materials in cells natural vaults
Post Your Comments:
(Date:5/22/2013)... NEW YORK CITY, May 22, 2013 U.S. Forest ... multi-disciplinary team that, with funding from the TKF Foundation, ... spaces help communities and individuals recover from tragedy. , ... is one of six projects selected for grant funding. ... spaces and sacred spaces in recovery and resiliency, the ...
(Date:5/22/2013)... a major new effort to educate the public and ... with clean water that looms ahead in the 21st ... the current edition of Chemical & Engineering News ... (ACS), the world,s largest scientific society. , Bassam Z. ... Schnoor, Ph.D., explain that shortages of reliable supplies of ...
(Date:5/22/2013)... DNA can endanger the whole organism, as they may ... (LMU) in Munich now report how byproducts of respiration ... The DNA in our cells controls the form and ... instructions for this are encoded in the linear sequence ... adenine (A), cytosine (C), guanine (G) and thymine (T). ...
Breaking Biology News(10 mins):'Landscapes of Resilience' to study how people use nature as a source of recovery 2DNA damage: The dark side of respiration 2
... Plays well with others. That popular phrase on ... level in higher education these days, as experts in ... address some of society,s biggest challenges, from a warming ... different disciplines and institutions collaborate? How do they work ...
... model of gastritis and stomach cancer, researchers from the Massachusetts ... pylori (H. pylori) infections reverses damage to the lining of ... May 1 issue of Cancer Research, a journal of the ... should lay to rest any question about whether and ...
... Relatively inexpensive interventions were effective in helping health care ... mothers during labor and delivery, reducing bleeding and sometimes ... University of North Carolina at Chapel Hill School of ... Journal of Medicine. Using teaching techniques that employed ...
Cached Biology News:Biologists are from Mars, chemists are from Venus? 2Biologists are from Mars, chemists are from Venus? 3Early treatment of stomach infection may prevent cancer 2Early treatment of stomach infection may prevent cancer 3More than words: childbirth training change improves safety, cuts unnecessary procedures 2
(Date:5/23/2013)... , May 23, 2013  Saddleback Memorial Medical ... recently became the first hospital on the West Coast ... This new surgical option provides women with a state-of-the-art, ... Marc Winter , M.D., a highly ... surgeon and medical director of minimally invasive surgery at ...
(Date:5/23/2013)... , May 23, 2013 Z Trim Holdings, ... ingredients to a variety of industries, announced that Chef ... panel discussion at this year,s National Restaurant Association ("NRA") ... on behalf of the Research Chefs Association.  Chef Ryan ... The Good, the Bad and the Ugly," joining four ...
(Date:5/23/2013)... DIEGO , May 23, 2013  Verenium Corporation ... company focused on the development and commercialization of high-performance ... , Chief Financial Officer, will present at two upcoming ... Mr. Black will present at the Second Annual Marcum ... the Grand Hyatt Hotel in New York City.  The ...
(Date:5/23/2013)... African Ancestry , Inc., ... of African descent, today announced new product enhancements ... of all races, myDNAmix determines various ancestries included ... Indigenous Americas (Native American), East Asia, West Sub-Saharan ... , Originally launched in late 2011, the enhanced ...
Breaking Biology Technology:Saddleback Memorial Surgeon First on the West Coast to Perform Single-Site Robotic Hysterectomy 2Saddleback Memorial Surgeon First on the West Coast to Perform Single-Site Robotic Hysterectomy 3Z Trim's Chef Erin Ryan sits on Expert Panel at NRA Show 2Z Trim's Chef Erin Ryan sits on Expert Panel at NRA Show 3Verenium To Present At Two Upcoming Conferences 2Verenium To Present At Two Upcoming Conferences 3AfricanAncestry.com Rolls Out Improved MyDNAMix Admixture Test for People of all Races; Enhancements Increase Accuracy in Estimation of Ancestral Makeup 2AfricanAncestry.com Rolls Out Improved MyDNAMix Admixture Test for People of all Races; Enhancements Increase Accuracy in Estimation of Ancestral Makeup 3
... HARBIN, China , May 12 /PRNewswire-Asia-FirstCall/ ... or "the Company") (Nasdaq: CSKI ), a leading,fully ... China ,("PRC"), today provided an update on the commercialization ... research and customer feedback, the,Company estimates aggregate incremental 2010 ...
... Institute,s Research and Development will Accelerate Lower Cost Wireless Health Solutions ... SAN ... Foundation today announced a grant of $20 million to support ... in March 2009 with an initial $45 million ...
... May 12 /PRNewswire-FirstCall/ - Oncolytics Biotech Inc. (TSX:ONC, NASDAQ: ... and operational highlights for the quarter ended March 31, 2010 ... "We ... both improved our understanding of REOLYSIN(R),s mechanism of action and provided ...
Cached Biology Technology:China Sky One Medical Provides Sales Forecast for 13 New Products 2China Sky One Medical Provides Sales Forecast for 13 New Products 3China Sky One Medical Provides Sales Forecast for 13 New Products 4Gary and Mary West Foundation Grants $20 Million to Advance Engineering Efforts Within the West Wireless Heath Institute 2Gary and Mary West Foundation Grants $20 Million to Advance Engineering Efforts Within the West Wireless Heath Institute 3Oncolytics Biotech(R) Inc. Announces First Quarter 2010 Results 2Oncolytics Biotech(R) Inc. Announces First Quarter 2010 Results 3Oncolytics Biotech(R) Inc. Announces First Quarter 2010 Results 4Oncolytics Biotech(R) Inc. Announces First Quarter 2010 Results 5Oncolytics Biotech(R) Inc. Announces First Quarter 2010 Results 6Oncolytics Biotech(R) Inc. Announces First Quarter 2010 Results 7Oncolytics Biotech(R) Inc. Announces First Quarter 2010 Results 8Oncolytics Biotech(R) Inc. Announces First Quarter 2010 Results 9
Request Info...
Request Info...
... The product contains 5 ml ... release cells from Dynabeads CD19 (Pan ... Dynabeads CD19 (Pan B) and released ... phenotypically unaltered. Cells are suitable for ...
... Kit #4 detects apoptosis on the ... permeability of cell membranes. This kit contains ... iodide nucleic acid stains. YO-PRO-1 stain selectively ... cells and labels them with moderate green ...
Biology Products: