Navigation Links
Genetically modified natural killer immune cells attack, kill leukemia cells

Natural killer (NK) immune system cells can be genetically modified to brandish a powerful "on-switch" that prompts them to aggressively attack and kill leukemic cells. This finding, from researchers at St. Jude Children's Research Hospital, suggests a way to improve the outcome of children who receive treatment for acute lymphoblastic leukemia (ALL) or other blood cancers.

Results of the St. Jude study are published in the current online issue of Blood.

The researchers demonstrated how to overcome significant technical hurdles that have until now slowed development of NK-based therapies for ALL, according to Dario Campana, M.D., Ph.D., a member of St. Jude Hematology-Oncology and Pathology, and senior author of the Blood report. Progress in adapting NK cells to the treatment of ALL had been significantly hampered because researchers were not able to grow large numbers of these immune cells in the laboratory, and because NK cells normally have only weak anti-leukemic activity.

The key breakthroughs made by the St. Jude team were the development of a laboratory technique for rapidly producing a large, pure population of NK cells from a small sample of blood; and developing a technique for genetically modifying NK cells so that they would become potent killers when they encountered leukemic cells.

In order to grow large populations of NK cells, the team started with samples of blood containing a variety of different immune system cells. They placed this sample into a dish containing a type of human leukemia cell called K562. Campana's team genetically modified the K562 cells so they carried on their surfaces many copies of two different proteins, 4-1BBL and IL-15. The genetically modified K562 cells quickly stimulated the expansion of the NK cell population to more than10,000 times their original number. The technique triggered growth of NK cells specifically, which greatly simplified the ability of the researchers to collect a pure popu
'"/>

Source:St. Jude Children's Research Hospital


Page: 1 2

Related biology news :

1. Genetically modified rice in China benefits farmers health, study finds
2. Genetically Modified Natural Killer Immune Cells Attack, Kill Leukemia Cells
3. Genetically engineered animals help in scientific research that may benefit children
4. Genetically modified maize not found in southern Mexico
5. Genetically engineered mosquitoes show resistance to dengue fever virus
6. Genetically altered mice no longer like cocaine
7. Genetically engineered blood protein can be used to split water into oxygen and hydrogen
8. Study finds that a womans chances of having twins can be modified by diet
9. UCSD discovery may help extend life of natural pesticide
10. Insight into natural cholesterol control suggests novel cholesterol-lowering therapy
11. UCLA scientists store materials in cells natural vaults
Post Your Comments:
(Date:8/22/2014)... Access to Research Careers) Program has announced the travel ... Practical Exercises Workshop which will be held on the ... 2014. These awards are meant to help support ... groups in the the FASEB Grant Writing Seminar & ... awards totaling $20,350. , The FASEB MARC Program is ...
(Date:8/22/2014)... This news release is available in German . ... certain helper substances, in PCFs proteins are fixated in ... highly stable crystals. Next, the HZB and Fudan University ... be used as functional materials. Their findings are being ... (DOI: 10.1038/ncomms5634). , Proteins are sensitive molecules. Everyone ...
(Date:8/22/2014)... multifunctional enzyme that localizes to the ... cholesterol-synthesizing activities. DHCR24 overexpression confers neuroprotection ... deposition. Dr. Xiuli Lu and colleagues ... two recombinant adenoviruses (Ad-rSYN1-DHCR24-myc and Ad-hSYN1-DHCR24-myc) ... neuronal cells. They also found that ...
Breaking Biology News(10 mins):Proteins: New class of materials discovered 2
... discovered the mother complete with her brood of some 20 ... of her soft part anatomy including legs and eyes. , ... of Leicester, Derek Siveter from Oxford, Mark Sutton from Imperial ... The team has made a digital image of the fossil ...
... Researchers at the National Institutes of Health have developed ... entire geographic regions, by eradicating the malaria parasite from ... tested only in mice, would prompt the immune system ... parasite from the digestive tract of a malaria-carrying mosquito, ...
... little mean sometimes ?especially when there's a choice bit of ... have shorter tempers than others. , Researchers in the ... of genes that affect aggression in the fruit fly Drosophila ... aggression in humans and other animals. , The study, ...
Cached Biology News:Malaria vaccine prompts victims' immune system to eliminate parasite from mosquitoes 2Malaria vaccine prompts victims' immune system to eliminate parasite from mosquitoes 3Fruit fly aggression studies have relevance to humans, animals 2Fruit fly aggression studies have relevance to humans, animals 3
(Date:8/22/2014)... /PRNewswire/ - BIOREM Inc. (TSXV: BRM) ("Biorem" or "the Company") today announced ... 2014.  Biorem,s complete 2014 second quarter financial statements and MD&A have been ... June 30, , Six-months ended June 30, ( in ... 2013 , 2014 , 2013 Revenue , ... 9,195 Gross profit , 56 , 1,485 , ...
(Date:8/22/2014)... particles are intensively investigated for application as ... agents and components in photonics and molecular ... fundamental for understanding physical and chemical properties, ... University, USA, have demonstrated that high-resolution electron ... three-dimensional structure in which all gold atoms ...
(Date:8/22/2014)... Research and Markets has announced the addition ... Reagents (Cloning, Epigenetics, PCR, Restriction Digestion, Sequencing) Market - ... The global molecular biology enzymes market was ... to grow at a CAGR of 13.74% to reach ... reagents find applications in a large number of fields ...
(Date:8/22/2014)... SC (PRWEB) August 22, 2014 ... indisputable acknowledgement is a national disgrace. Furthermore, every ... in establishing the current, deplorable state of unorganized ... "5 great mistakes," to merely serve as a ... the extent of colossal failure(s) that have accumulated ...
Breaking Biology Technology:Biorem Reports 2014 Second Quarter Results 2Biorem Reports 2014 Second Quarter Results 3A breakthrough in imaging gold nanoparticles to atomic resolution by electron microscopy 2Global Molecular Biology Enzymes, Kits, & Reagents (Cloning, Epigenetics, PCR, Restriction Digestion, Sequencing) Market - Forecast to 2018 2Global Molecular Biology Enzymes, Kits, & Reagents (Cloning, Epigenetics, PCR, Restriction Digestion, Sequencing) Market - Forecast to 2018 35 Great Mistakes in Healthcare and How to Fix Them by Dr. Ira Williams 2
... 4, 2010 -- Thin layers of oxide materials and their ... the first time by researchers at the Center for Nanophase ... Laboratory, providing new insight into the complicated link between their ... ability to see in color, or in 3-D," said the ...
... Aug. 4 Forte, LLC, today ... web-based probate database and estate recovery application that ... Finder OnDemand provides access to a proprietary database ... powerful matching algorithms that accurately match deceased accounts ...
... Aug. 4 New England Biolabs is ... Genome Sciences Center has selected New England Biolabs as ... construction reagents. NEBNext DNA Sample Prep Reagent Sets contain ... for sample preparation for next generation sequencing, as well ...
Cached Biology Technology:Unprecedented look at oxide interfaces reveals unexpected structures on atomic scale 2Forte Launches Probate Finder OnDemand™ 2Forte Launches Probate Finder OnDemand™ 3Canada's Michael Smith Genome Sciences Center Validates NEBNext™ DNA Sample Preparation Reagents From New England Biolabs for Use in Next Generation Sequencing 2Canada's Michael Smith Genome Sciences Center Validates NEBNext™ DNA Sample Preparation Reagents From New England Biolabs for Use in Next Generation Sequencing 3
... of samples may be carried out using this ... minimum operator attention. System control and data ... CE 4900. The elegant, powerful and very ... and Windows 98 and 2000., The supplied automatic ...
... ideal for routine binary separations. Excellent detection ... 4201 UV-Visible variable wavelength detector. Ultra-fine control ... two highly accurate and precise, high pressure ... pumps., Chromatograms may be plotted on a printer ...
...
... Human Raji cells were cultured in RPMI 1640 ... the log phase of growth. In order ... cells were fixed in acetone-methanol. The cells ... coated slide, with each wells surface specifically treated ...
Biology Products: