Navigation Links
Genetically engineered mosquitoes show resistance to dengue fever virus

process of self-destruction happens only after the virus has already replicated and been transmitted; however, the researchers found a way to control and speed up the process. They accomplished this by cloning a section of the virus' RNA and injected two inverse copies of it into mosquito embryos. The copies formed a double-stranded RNA, which, as expected, bound with dicer-2 and was chopped up. The virus never had the opportunity to replicate. As a result, they could "inoculate" mosquitoes with a form of the virus that would essentially be benign.

Joining James on the study, funded by a 2001 grant from the National Institutes of Health, were researchers from Colorado State University and from Virginia Polytechnic Institute and State University.

James and his colleagues performed tests on a family of mosquitoes descended from one of the original embryos that survived the procedure. They found that the vast majority of that family was highly resistant to dengue infection. They also were able to detect the engineered RNA in the mosquitoes, a sign that the genetic alteration had been successful and passed down through reproduction. Furthermore, when that genetic modification was reversed, the mosquitoes were as susceptible to the virus as they had been before the procedure.

Dengue fever is endemic in more than 100 countries in Africa, the Americas, the Eastern Mediterranean, Southeast Asia and the Western Pacific. The virus is transmitted to people by mosquitoes of the species Aedes aegypti. The World Health Organization estimates 50 million cases of dengue infection each year. Approximately 20,000 people die annually from the disease.

James, a professor of microbiology and molecular genetics, and of molecular biology and biochemistry, has made a number of significant advances on genetic approaches to interrupt malaria parasite and dengue virus transmission by mosquitoes. He has received a number of international awards for his research
'"/>

Source:University of California - Irvine


Page: 1 2 3

Related biology news :

1. Genetically modified natural killer immune cells attack, kill leukemia cells
2. Genetically modified rice in China benefits farmers health, study finds
3. Genetically Modified Natural Killer Immune Cells Attack, Kill Leukemia Cells
4. Genetically engineered animals help in scientific research that may benefit children
5. Genetically modified maize not found in southern Mexico
6. Genetically altered mice no longer like cocaine
7. Genetically engineered blood protein can be used to split water into oxygen and hydrogen
8. Insects develop resistance to engineered crops
9. Bioengineered tissue implants regenerate damaged knee cartilage
10. New engineered drug may offer prolonged arthritis relief
11. Can engineered immune cells stop AIDS?
Post Your Comments:
(Date:4/23/2014)... Angeles, London (April 23, 2014). "I think one can argue ... pathwayas well as doing everything else that we canthen we ... Tom Wigley, one of the world,s foremost climate researchers, in ... , published by SAGE. Refusing to take significant action on ... eventually be needed to address the problem, Wigley explains in ...
(Date:4/22/2014)... team of Yale researchers will lead a five-year, $3 ... rain events is affecting the transport of dissolved organic ... they say could alter the chemical composition and water ... With funding from the National Science Foundation,s MacroSystems Biology ... across the watershed, which begins in Canada and runs ...
(Date:4/22/2014)... must be aware of the broad patent landscape and ... a new paper from Rice University,s Baker Institute for ... the journal Regenerative Medicine , the paper is ... in the case Association for Molecular Pathology (AMP) v. ... court case and rulings garnered discussion in the public ...
Breaking Biology News(10 mins):Is nuclear power the only way to avoid geoengineering? 2Connecticut River watershed study will assess impacts of extreme rain events 2Connecticut River watershed study will assess impacts of extreme rain events 3New patenting guidelines are needed for biotechnology 2New patenting guidelines are needed for biotechnology 3
... uterine fibroids and significantly relieves fibroid-related symptoms in ... clinical trial reported in the June issue of ... (MRgFUS) allows radiologists to precisely target fibroids without ... immediately stops blood flow in the treated fibroid ...
... University of Toronto researchers have uncovered the basis by ... also discovered how the HIV virus works to counteract ... for pregnant women in malaria-ravished regions. , Malaria is ... than one million people every year. While the disease ...
... of smell, which in many species is critical for finding ... biologists, sharks can not use just their noses to locate ... called the lateral line. The lateral line is an organ ... and vibration in the surrounding water. According to the research ...
Cached Biology News:Focused ultrasound relieves fibroid symptoms in women 2HIV and malaria combine to adversely affect pregnant women and their infants 2New research shows sharks use their noses and bodies to locate smells 2New research shows sharks use their noses and bodies to locate smells 3
(Date:1/15/2014)... ­ RedBrick Health , a fast-growing leader in ... that EmblemHealth , the New York ... providing the RedBrick Compass health assessment, combined with the ... its members. EmblemHealth is among the first health plans ...
(Date:1/15/2014)... Rochester, NY (PRWEB) January 15, 2014 The ... cause a major disease. One of these latent viruses is ... is rheumatoid arthritis (RA). Rheumatoid arthritis (RA) is a chronic ... the theory, a study found that RA patients have high ...
(Date:1/15/2014)... , Jan. 15, 2014 TaiGen Biotechnology Company, Limited ... agreement with R-Pharm, a leading Russian pharmaceutical company, to ... Russian Federation , Turkey ... States (CIS). Nemonoxacin is a novel antibiotic for the treatment ...
(Date:1/14/2014)... 2014 As pet owners drew up their lists of New ... "Take better care of my furry companion." Nowadays there are pet ... carrying cases to take the little canine or feline darlings along ... to buy some pricey toys at the pet store. But anyone ...
Breaking Biology Technology:EmblemHealth Selects RedBrick Health to Power its Next-Generation Health Engagement and Behavior Change System 2EmblemHealth Selects RedBrick Health to Power its Next-Generation Health Engagement and Behavior Change System 3Study: Rheumatoid Arthritis (RA) Patients Have EBV; The CBCD Says this is Consistent with Microcompetition 2Study: Rheumatoid Arthritis (RA) Patients Have EBV; The CBCD Says this is Consistent with Microcompetition 3TaiGen Biotechnology Signed Exclusive License Agreement with R-Pharm for Nemonoxacin (Taigexyn(R)) 2TaiGen Biotechnology Signed Exclusive License Agreement with R-Pharm for Nemonoxacin (Taigexyn(R)) 3TaiGen Biotechnology Signed Exclusive License Agreement with R-Pharm for Nemonoxacin (Taigexyn(R)) 4New Year's Resolution: Give Pets the Gift of Top-Notch Health Care 2
... it expands ... line of predictive diagnostic tests, EMERYVILLE, Calif., Sept. ... acquired Lipomics Technologies of West,Sacramento, Calif. The acquisition will ... terms were not disclosed., The acquisition brings together ...
... 17 Amicus Therapeutics,(Nasdaq: FOLD ), today announced ... make a presentation at the UBS Global Life Sciences,Conference ... in New York., An audio webcast of the ... http://www.amicustherapeutics.com . Participants should allow,approximately five to ten ...
... a finding that could speed the use of sensors or ... shown that certain types of tiny organic particles, when heated ... layer of a thin polymer film and then can reversibly ... , Selectively bringing a number of particles to a surface ...
Cached Biology Technology:Tethys Bioscience Announces Acquisition of Lipomics Technologies 2Tethys Bioscience Announces Acquisition of Lipomics Technologies 3NC State engineers discover nanoparticles can break on through 2
...
Experion HighSens chips are the microfluidic chips used to perform high-sensitivity RNA analysis (picogram levels) with the Experion automated electrophoresis system. Each chip has the capacity to ru...
... Second Mitochondria Derived Activator of ... 20 mM HEPES, pH 7.5 AVOID FREEZE/THAW CYCLES. ... Smac/DIABLO with a carboxy terminal His•Tag ® ... E. coli . Smac/DIABLO is released along with ...
... to Decorin ( Abpromise for ... Antigen: Synthetic peptide: IGPEVPDDRDFEPS conjugated ... 6-19 of Human Decorin (fragment 36-49 ... II). Entrez GeneID: ...
Biology Products: