Navigation Links
Genetically altered mice no longer like cocaine

Researchers found that they could eliminate the rewarding effect of cocaine on mice by genetically manipulating a key target of the drug in the animal's brain.

While the researchers aren't suggesting that these genetic modifications be made in humans, the work brings to light the key protein that controls cocaine's effects in the body, which may help scientists develop medications that achieve the same results and therefore help addicts overcome their dependence.

Right now there are no such treatments on the market, said Howard Gu, the study's lead author and an associate professor of pharmacology and psychiatry at Ohio State University .

The study confirms that the dopamine transporter ?a protein that moves the neurotransmitter dopamine from outside of a neuron into the inside of the cell ?is a prime target for developing drugs to fight cocaine addiction.

"Cocaine blocks dopamine transporters, and this action ultimately is what makes a person feel high," Gu said. "We found that cocaine would not produce a high if it could not block the transporters."

He and his colleagues reported their findings the week of May 29 in the Proceedings of the National Academy of Sciences.

Dopamine is a chemical messenger vital to the regular functioning of the central nervous system. Under normal circumstances it flows into and out of neurons.

But cocaine blocks dopamine transporters from taking up dopamine, leaving it outside the cells, which excites the nervous system to the point where a cocaine user feels a high, Gu said.

He and his colleagues raised laboratory mice with genetic alterations in the gene that codes for the dopamine transporter.

"By doing so we created a dopamine transporter that resists cocaine but also retains its function of taking up dopamine and carrying it back to the neurons," Gu said.

The researchers tested cocaine's effects on normal mice and on mice with modified dopamine transpo
'"/>

Source:Ohio State University


Page: 1 2 3

Related biology news :

1. Genetically modified natural killer immune cells attack, kill leukemia cells
2. Genetically modified rice in China benefits farmers health, study finds
3. Genetically Modified Natural Killer Immune Cells Attack, Kill Leukemia Cells
4. Genetically engineered animals help in scientific research that may benefit children
5. Genetically modified maize not found in southern Mexico
6. Genetically engineered mosquitoes show resistance to dengue fever virus
7. Genetically engineered blood protein can be used to split water into oxygen and hydrogen
8. Salmonella survives better in stomach due to altered DNA
9. Innovative coating could give medical implants a longer life
10. Fluorescing lab worms signal longer life spans
11. Discoveries by UAB and Florida scientists may help transplanted organs survive longer
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Genetically altered mice longer like cocaine

(Date:7/21/2014)... A team of University of California, Riverside Bourns ... placed under the grates of a backyard grill reduces by ... cooking. , The one-eighth inch thick steel carbon plate with ... by cutting a slit into the grill to allow the ... be adopted by grill manufacturers who could sell new grills ...
(Date:7/21/2014)... at the INRS nergie Matriaux Tlcommunications Research Centre ... and temporal resolution greatly exceeding that obtained to ... laser source to shoot a molecular movie of ... article presenting the advancement was recently published in ... , "The approach we developed combines multiphoton ionization ...
(Date:7/21/2014)... meat contributes to climate change, due to greenhouse gasses ... are on the rise and that beef cattle are ... types of animals. It is published by Climactic ... gas when it comes to climate change. It is ... the greatest portion of greenhouse gas totals. But methane ...
Breaking Biology News(10 mins):Catching grease to cut grill pollution 2Climate: Meat turns up the heat 2
... This press release is available in Spanish . ... del Mar) have proven that the absence of the 14-3-3 ... these cells, capacity to activate the signalling of a protein ... activation of NF-kB in tumours was also identified as the ...
... Biochemists at the University of California, Riverside report a new ... twins and even triplets in plant seeds. Daniel ... an associate research biochemist in the Department of Biochemistry ... a naturally occurring enzyme that recycles vitamin C in plants ...
... Calif. The University of California, Riverside is hosting the ... through June 22, 2012. Held this year at the ... oral presentations and 130 poster presentations. Because research papers on ... the rate of more than 2000 per year, the workshop, which ...
Cached Biology News:A new indicator for breast cancer relapse identified 2Link between vitamin C and twins can increase seed production in crops 2Link between vitamin C and twins can increase seed production in crops 315th Vitamin D Workshop begins tomorrow 215th Vitamin D Workshop begins tomorrow 3
(Date:7/18/2014)... , July 18, 2014  On ... highlighting AbbVie and Shire,s complementary fit and ... A copy of the infographic materials ... http://www.abbvieinvestor.com/phoenix.zhtml?c=251551&p=irol-disclaimer-documents In accordance ... a copy of this announcement will be ...
(Date:7/18/2014)... MA (PRWEB) July 18, 2014 Provia ... to its growing Advisory Board. Dr. Vaught has ... for over 20 years. As one of the ... Biological and Environmental Repositories - in 1999, he served ... is again president-elect. , In 2005, Dr. Vaught began ...
(Date:7/17/2014)... 17, 2014  Prana Biotechnology (NASDAQ: PRAN ... its clinical development program for Alzheimer,s disease. ... Neuroscience and Mental Health, The University of Melbourne, will ... EURO trials in his presentation at the Alzheimer,s Association ... The presentation is entitled: "How to ...
(Date:7/17/2014)... the design and development of new, more efficient solar ... Berkeley National Laboratory (Berkeley Lab) have developed the first ... model free of adjustable or empirical parameters for ... carriers are electrical charge carriers - electrons and holes ... thermal equilibrium. , "Hot carrier thermalization is a major ...
Breaking Biology Technology:NOT FOR RELEASE, PUBLICATION OR DISTRIBUTION IN WHOLE OR IN PART, DIRECTLY OR INDIRECTLY, IN, INTO OR FROM ANY JURISDICTION WHERE TO DO SO WOULD CONSTITUTE A VIOLATION OF THE RELEVANT LAWS OR REGULATIONS OF SUCH JURISDICTION 2NOT FOR RELEASE, PUBLICATION OR DISTRIBUTION IN WHOLE OR IN PART, DIRECTLY OR INDIRECTLY, IN, INTO OR FROM ANY JURISDICTION WHERE TO DO SO WOULD CONSTITUTE A VIOLATION OF THE RELEVANT LAWS OR REGULATIONS OF SUCH JURISDICTION 3NOT FOR RELEASE, PUBLICATION OR DISTRIBUTION IN WHOLE OR IN PART, DIRECTLY OR INDIRECTLY, IN, INTO OR FROM ANY JURISDICTION WHERE TO DO SO WOULD CONSTITUTE A VIOLATION OF THE RELEVANT LAWS OR REGULATIONS OF SUCH JURISDICTION 4NOT FOR RELEASE, PUBLICATION OR DISTRIBUTION IN WHOLE OR IN PART, DIRECTLY OR INDIRECTLY, IN, INTO OR FROM ANY JURISDICTION WHERE TO DO SO WOULD CONSTITUTE A VIOLATION OF THE RELEVANT LAWS OR REGULATIONS OF SUCH JURISDICTION 5NOT FOR RELEASE, PUBLICATION OR DISTRIBUTION IN WHOLE OR IN PART, DIRECTLY OR INDIRECTLY, IN, INTO OR FROM ANY JURISDICTION WHERE TO DO SO WOULD CONSTITUTE A VIOLATION OF THE RELEVANT LAWS OR REGULATIONS OF SUCH JURISDICTION 6NOT FOR RELEASE, PUBLICATION OR DISTRIBUTION IN WHOLE OR IN PART, DIRECTLY OR INDIRECTLY, IN, INTO OR FROM ANY JURISDICTION WHERE TO DO SO WOULD CONSTITUTE A VIOLATION OF THE RELEVANT LAWS OR REGULATIONS OF SUCH JURISDICTION 7Dr. Jim Vaught, Ph.D., Former Chief of BBRB, Joins Provia Laboratories as Advisory Board Member 2Dr. Jim Vaught, Ph.D., Former Chief of BBRB, Joins Provia Laboratories as Advisory Board Member 3Prana Alzheimer's disease Development Program update 2Prana Alzheimer's disease Development Program update 3Prana Alzheimer's disease Development Program update 4Prana Alzheimer's disease Development Program update 5First ab initio method for characterizing hot carriers 2First ab initio method for characterizing hot carriers 3
... If you have a creative idea or invention, or you ... want to protect, the first thing you do is contact ... that you have protected your invention, so you're set, right? ... sage advice: look both ways before you cross the street, ...
... a private research center south of Madison, a group ... to talk about the ethical choices presented by biotechnology's ... forum will be the memory of Terri Schiavo. , ... questions surrounding patients such as Schiavo, the brain-damaged Florida ...
... seems like there's always one person in a crowd who ... obituaries. Not me. I'm compulsive about reading the job classifieds. ... to fathom the difference between the ubiquitous "excellent communication skills" ... them a quick scan every day, even if it happens ...
Cached Biology Technology:Five patent tips for start-up companies 2Five patent tips for start-up companies 3Schiavo's death calls attention to ethical issues weighed at Bioethics Forum 2Schiavo's death calls attention to ethical issues weighed at Bioethics Forum 3Is IT leadership a position or an attitude? 2Is IT leadership a position or an attitude? 3
...
Recombinant Rat Leptin, CF...
Adhesive seal-tab, for HybriWell™ hybridization sealing system *set of 400*...
... The CultureWell cell culture systems provide ... cells for staining and imaging. Each ... with standard optical-quality coverslips in cell ... provided sterile and ready to use. ...
Biology Products: