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'Genetic network' guards against lethal DNA damage

ensate for each other's absence. The parts we're pulling out of yeast are genes, and we look to see what happens when both of the genes are pulled out."

The dSLAM technology takes advantage of DNA barcode that identifies which genes a yeast cell is missing. This is much like using a commercial barcode in a store to quickly identify items at the checkout counter. The scanner in this case is a microarray: a grid of thousands of spots on a piece of glass that holds a unique "sensor" strand of DNA that matches one of the barcodes. Machines then read the microarray to identify which of the sensors found matching barcodes that identified specific yeast cells with specific mutations. If two genes that compensated for each other are knocked out, the yeast cell dies and the microarray doesn't record that cell, Boeke noted. That means the two genes interact with each other, he said.

"This strategy for finding interacting genes will open the door to an extraordinarily rich source of new data on DNA damage, repair, and human diseases," Boeke added.


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Source:Johns Hopkins Medical Institutions


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