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Genetic factors are linked to fever following smallpox vaccination

nt risks of fever.

“Vaccines are the safest and most effective way to prevent a number of very important childhood and adult diseases,” Dr. Stanley remarked. “Our work is designed to identify ways we might make vaccines even more acceptable in the future by discovering ways to further reduce the chance of minor adverse events.”

In an accompanying editorial, James E. Crowe Jr., MD, of Vanderbilt University Medical Center, echoes Dr. Stanley’s sentiments that the findings represent an important preliminary step in understanding the variations in host responses to vaccines, and notes that further studies will need to replicate these findings, and to test other vaccines. Both Drs. Stanley and Crowe mention that the results may have important implications when it comes to the future goal of identifying individuals at risk for fever before they are given a specific vaccination. Crowe writes, “The long-term goal is to determine genetic features that could be determined prior to vaccination, allowing practitioners to modulate the vaccination plan according to risk. This type of practice, the goal of personalized predictive medicine, appears closer in feasibility than ever given the pace of genetic testing.”


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Source:Infectious Diseases Society of America


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