Navigation Links
Genetic defects give the immune system the green light to attack the pancreas

Scientists at Joslin Diabetes Center have found genetic regions that, when defective, allow the immune system to attack the pancreas ?the first in a series of mis-steps that lead to type 1 diabetes. Armed with these findings published March 22 in the journal Immunity, the researchers are now trying to hone in on the exact genes involved, in mice and in human patients.

“The significance of this study is that we found the chromosomal regions involved and can now zero in on the precise genes,?said Diane Mathis, Ph.D., the study’s principal investigator along with Christophe Benoist, M.D., Ph.D. They head the Section on Immunology and Immunogenetics at Joslin, and hold joint William T. Young Chairs in Diabetes Research. They are also Professors of Medicine at Harvard Medical School. The work was spearheaded by a group of Joslin fellows, hailing from across the globe: Silvia Zucchelli, Ph.D., who has now returned to Italy; Phil Holler, Ph.D., from the U.S.; and Tetsuya Yamagata, M.D., Ph.D, from Japan.

The genetic defect keeps the body from properly dealing with “errant?immune cells that it normally eliminates by a process called immunological tolerance. These immune cells then attack the insulin-producing beta cells in the pancreas, mistaking them as foreign invaders. “It’s critical for the immune system to recognize and tolerate tissues that belong in the body, which immunologists call ‘tolerance,’?said Dr. Zucchelli. “Previous studies have shown that when the T-cells don’t learn this tolerance, they can infiltrate the pancreas and attack the insulin-producing beta cells.?This first step in the onset of type 1 diabetes is called insulitis. Later in life, within weeks or even years, full-blown type 1 diabetes emerges.

An estimated 1 million people in the United States have type 1 diabetes. Their pancreatic beta cells can no longer make insulin. Without this crucial hormone, their body cannot convert food into energy. To sustain life, they must get
'"/>

Source:Joslin Diabetes Center


Page: 1 2 3

Related biology news :

1. Novel Asthma Study Shows Multiple Genetic Input Required; Single-gene Solution Shot Down
2. Genetically modified natural killer immune cells attack, kill leukemia cells
3. Ants Genetic Engineering Leads To Species Interdependency
4. Genetic Variation Visualization - From EMBL
5. Genetically modified rice in China benefits farmers health, study finds
6. Infants With Rare Genetic Disease Saved by Cord Blood Stem Cells
7. Genetically Modified Natural Killer Immune Cells Attack, Kill Leukemia Cells
8. Maine Researchers Find Exceptions to Old Rules of Genetic Inheritance
9. Genetic therapy reverses nervous system damage in animal model of inherited human disease
10. Infants with Rare Genetic Disease Saved By Cord Blood Stem Cells
11. Researchers Find New Technique To Identify Fetal Genetic Material From Amniotic Fluid
Post Your Comments:
(Date:6/18/2013)... Scientists at the University of Calgary,s Faculty of Medicine ... the body from harmful bacteria. Platelets, a component of ... search for specific bacteria, and upon detection, seal it ... which were published in Nature Immunology this ... of immunity. , "The science community has known that ...
(Date:6/18/2013)... University, sophisticated computational models and advances in graphical ... interplay between genomic data, virus structure and the ... for replication. , "We hope that ... researchers alter virus assembly, leaving viruses unable to ... of the scientific paper describing the technique, published ...
(Date:6/18/2013)... National Institutes of Health has awarded $12.7 million ... selection of pharmaceutical industry compounds to explore new ... Alzheimer,s disease, Duchenne muscular dystrophy and schizophrenia. The ... for Existing Molecules, is led by the National ... by the NIH Common Fund. , The process ...
Breaking Biology News(10 mins):Immunity mechanism discovered 2Computer modeling technique goes viral at Brandeis 2NIH to fund collaborations with industry to identify new uses for existing compounds 2NIH to fund collaborations with industry to identify new uses for existing compounds 3NIH to fund collaborations with industry to identify new uses for existing compounds 4
... experimental drug prevented and treated both type 2 diabetes ... unhealthy diets and were genetically predisposed to these common ... on June 6, 2007. The team was led by ... Genetics and Complex Diseases at the Harvard School of ...
... very cold case: the disappearance of the last woolly mammoths, ... according to a June 7th report published online in Current ... the bones, teeth, and tusks of the extinct mammoths revealed ... interglacial period. After the mammoths’ migration, the population apparently leveled ...
... University of Minnesota researchers report that umbilical cord ... outcomes than bone marrow transplants, according to an ... for International Blood and Marrow Transplant Research (CIBMTR), ... the first study that directly compares matched bone ...
Cached Biology News:In mice, drug protects against diabetes and atherosclerosis 2In mice, drug protects against diabetes and atherosclerosis 3In mice, drug protects against diabetes and atherosclerosis 4Ancient DNA traces the woolly mammoth's disappearance 2Research shows cord blood comparable to matched bone marrow 2Research shows cord blood comparable to matched bone marrow 3
(Date:6/18/2013)... Cord Blood Corporation (NYSE: CO ) ("CCBC" ... collection, laboratory testing, hematopoietic stem cell processing, and stem ... results for the fourth quarter and full year of ... Fourth Quarter of Fiscal 2013 Highlights , ... by 33.3% to RMB133.0 million ($21.4 million) from RMB99.8 ...
(Date:6/18/2013)... June 18, 2013 (PRWEB) June 18, 2013 ... and attendance system in North America, has introduced ... employee data and payroll records between ExakTime’s software ... automates ExakTime software setup and keeps employee ... employee data from a business’ current payroll software, ...
(Date:6/18/2013)... (PRWEB) June 18, 2013 Demanding industrial ... Lenses engineered of synthetic Sapphire and Glass Ball Lenses, ... from Swiss Jewel Company , of Philadelphia , ... expanding and collimating the light beams without the need ... clarity and natural durability (9 mohs) make it the ...
(Date:6/18/2013)... June 18, 2013 DuPont welcomes 48 ... 11th annual DuPont National AgriScience Teachers Ambassador Academy this ... in Chestertown, Md. , The NATAA “Ag ... and is a special project of the National ... Agricultural Educators (NAAE) . The highly recommended agriscience ...
Breaking Biology Technology:China Cord Blood Corporation Reports Financial Results for the Fourth Quarter and Full Year of Fiscal 2013 2China Cord Blood Corporation Reports Financial Results for the Fourth Quarter and Full Year of Fiscal 2013 3China Cord Blood Corporation Reports Financial Results for the Fourth Quarter and Full Year of Fiscal 2013 4China Cord Blood Corporation Reports Financial Results for the Fourth Quarter and Full Year of Fiscal 2013 5China Cord Blood Corporation Reports Financial Results for the Fourth Quarter and Full Year of Fiscal 2013 6China Cord Blood Corporation Reports Financial Results for the Fourth Quarter and Full Year of Fiscal 2013 7China Cord Blood Corporation Reports Financial Results for the Fourth Quarter and Full Year of Fiscal 2013 8China Cord Blood Corporation Reports Financial Results for the Fourth Quarter and Full Year of Fiscal 2013 9China Cord Blood Corporation Reports Financial Results for the Fourth Quarter and Full Year of Fiscal 2013 10China Cord Blood Corporation Reports Financial Results for the Fourth Quarter and Full Year of Fiscal 2013 11China Cord Blood Corporation Reports Financial Results for the Fourth Quarter and Full Year of Fiscal 2013 12China Cord Blood Corporation Reports Financial Results for the Fourth Quarter and Full Year of Fiscal 2013 13ExakTime Introduces AccountLinx Plus 2Swiss Jewel Introduces the Crown Jewels of Fiber-Optic Connectors 2DuPont Sponsors National AgriScience Ambassador Academy 2DuPont Sponsors National AgriScience Ambassador Academy 3
... VANCOUVER, April 17 /PRNewswire-FirstCall/ - Angiotech Pharmaceuticals,Inc. ... global specialty pharmaceutical and,medical device company, today ... the U.S. Food and Drug Administration (FDA) ... Catheter (CVC) in,the United States., "The ...
... with Increased Investment in ... Research & Development, DEERFIELD, Ill., April 17 ... for,the first quarter of 2008, and raised its financial outlook for the ... million, a 6,percent increase compared to $403 million in the first quarter ...
... and more transparency in federal risk research investment, the ... rather than a foregone conclusion, says Dr. Andrew Maynard, ... Nanotechnologies (PEN). This sentiment was voiced today by Dr. ... Committees hearing on the National Nanotechnology Initiative Amendments Act ...
Cached Biology Technology:Angiotech's novel 5-FU Central Venous Catheter receives FDA 510(k) clearance 2Angiotech's novel 5-FU Central Venous Catheter receives FDA 510(k) clearance 3Angiotech's novel 5-FU Central Venous Catheter receives FDA 510(k) clearance 4Angiotech's novel 5-FU Central Venous Catheter receives FDA 510(k) clearance 5Baxter Reports Solid First Quarter Financial Results and Raises Full-Year Outlook 2Baxter Reports Solid First Quarter Financial Results and Raises Full-Year Outlook 3Baxter Reports Solid First Quarter Financial Results and Raises Full-Year Outlook 4Baxter Reports Solid First Quarter Financial Results and Raises Full-Year Outlook 5Baxter Reports Solid First Quarter Financial Results and Raises Full-Year Outlook 6Baxter Reports Solid First Quarter Financial Results and Raises Full-Year Outlook 7Baxter Reports Solid First Quarter Financial Results and Raises Full-Year Outlook 8Baxter Reports Solid First Quarter Financial Results and Raises Full-Year Outlook 9Baxter Reports Solid First Quarter Financial Results and Raises Full-Year Outlook 10Baxter Reports Solid First Quarter Financial Results and Raises Full-Year Outlook 11Baxter Reports Solid First Quarter Financial Results and Raises Full-Year Outlook 12Baxter Reports Solid First Quarter Financial Results and Raises Full-Year Outlook 13Baxter Reports Solid First Quarter Financial Results and Raises Full-Year Outlook 14Baxter Reports Solid First Quarter Financial Results and Raises Full-Year Outlook 15Baxter Reports Solid First Quarter Financial Results and Raises Full-Year Outlook 16Baxter Reports Solid First Quarter Financial Results and Raises Full-Year Outlook 17Baxter Reports Solid First Quarter Financial Results and Raises Full-Year Outlook 18Baxter Reports Solid First Quarter Financial Results and Raises Full-Year Outlook 19Limited transparency in federal nanotech research may hamper development 2
... Freedom EVOware is Tecans state-of-the-art software for ... pipetting and scheduling in a single, scalable ... intuitive and consistent, simplifying the control of ... on a Freedom EVO 100 with one ...
... Vesicles Isolation Kit provides all the ... synaptic vesicle fraction. The isolation procedure ... the synaptosomes, and differential centrifugation followed ... kit also contains an antibody specific ...
This depletion cocktail is tailored to deplete IgE-bearing (I.e. basophils and mast cells) from whole blood...
... The BAS-2500 is ... applications: Molecular Biology (1D ... protein blots, Macroarrays); Pharmacokinetics ... autoradiography, thin layer chromatography); ...
Biology Products: