Navigation Links
Genetic Variation Visualization - From EMBL

"Because up to 75 percent of breast cancer patients have an abnormality in a specific cell signaling pathway, drugs that target different molecules along that pathway may be especially effective for treating the disease, says a researcher from The University of Texas M. D. Anderson Cancer Center."

A clearer picture is now emerging about the importance of the phosphatidylinositol 3 kinase (PI3K) pathway to breast cancer development, says Gordon Mills, M.D., Ph.D., a professor and chair of the Department of Molecular Therapeutics. This pathway, which is linked to critical growth factor receptors and is involved in programmed cell death, is aberrant at multiple levels in breast cancer, including mutations in PI3K itself or its many “downstream?players, such as PTEN, or AKT. “There is a lot of crosstalk between the PI3K pathway and other pathways, a lot of feed-forward and feedback loops,?says Mills. “But I and others believe there are central nodes between these intersecting circles that can be effectively targeted with drugs.?Only one PI3K pathway inhibitor is in use to date, but others are increasingly being developed and tested, says Mills, who is discussing the importance of this pathway at the annual San Antonio Breast Cancer Symposium meeting. “At least 20 different companies have recognized the importance of the pathway in breast cancer and are trying to develop drugs that target it.?In the future, breast cancer tissue samples from newly diagnosed patients can be tested for their specific PI3K pathway abnormality in order to find a drug that zeroes in on what may be the cancer’s Achilles?heel, Mills says. “Using those drugs in combination with other treatments such as chemotherapy may significantly advance breast cancer care,?he says.
'"/>

Source:


Page: 1

Related biology news :

1. Novel Asthma Study Shows Multiple Genetic Input Required; Single-gene Solution Shot Down
2. Genetically modified natural killer immune cells attack, kill leukemia cells
3. Ants Genetic Engineering Leads To Species Interdependency
4. Genetically modified rice in China benefits farmers health, study finds
5. Infants With Rare Genetic Disease Saved by Cord Blood Stem Cells
6. Genetically Modified Natural Killer Immune Cells Attack, Kill Leukemia Cells
7. Genetic defects give the immune system the green light to attack the pancreas
8. Maine Researchers Find Exceptions to Old Rules of Genetic Inheritance
9. Genetic therapy reverses nervous system damage in animal model of inherited human disease
10. Infants with Rare Genetic Disease Saved By Cord Blood Stem Cells
11. Researchers Find New Technique To Identify Fetal Genetic Material From Amniotic Fluid
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Genetic Variation Visualization From EMBL

(Date:1/22/2015)... MADISON, Wis. , Jan. 15, 2015  BellBrook ... for drug discovery, announced the launch of a ... of the company,s Transcreener UDP Assay, a high ... enzymes. The new assay will allow for sensitive ...
(Date:1/22/2015)... Report Issued by Small Cap IR. In 2011, Nilson Report,s ... at merchants on the leading payment cards rose to $135.3 ... and prepaid cards reached 6.54 billion.  Eight million credit card ... in 2012, and credit and debit card fraud resulted in ...
(Date:1/22/2015)... Jan. 22, 2015 Infinisource has launched its new NXG ... model. The G2 sets a higher standard for collecting attendance ... management solution. With plug-and-play installation, touch screen interface and seamless ... a robust time collection solution for the small to mid-size ...
Breaking Biology News(10 mins):BellBrook Labs Launches a High Throughput Screening Assay for Glycosyltransferases with TR-FRET Readout 2$4.80 Near Term Price Target with "Buy" given by CapRock Research for NXT-ID, Inc. (NASDAQ: NXTD) issued by Small Cap IR 2Infinisource's NXG series sets new time clock standard 2
... Tropical Research Institute and University of Costa Rica asked ... webs. Repeating old, widely quoted but poorly documented studies ... legs are protected by a covering of branching hairs ... published online in the journal, Naturwissenschaften . , ...
... of our brain hemispheres is more active than the ... both sides working together. PD Dr. Martina Manns and ... such specializations and co-operations arise. Based on a pigeon-model, ... experimental way, that the ability to combine complex impressions ...
... Scientists from Binghamton University and Cardiff University, and ... discovery of the floor of the world,s oldest forest ... of Nature , a leading international journal of ... of dinosaur footprints," said William Stein, associate professor of ...
Cached Biology News:When one side does not know about the other one 2Floor of oldest forest discovered in Schoharie County 2Floor of oldest forest discovered in Schoharie County 3Floor of oldest forest discovered in Schoharie County 4
(Date:2/27/2015)... -- Steep Hill, the industry leader in cannabis testing and ... a full service medical cannabis quality assurance laboratory in ... scientific tools and methodology to the state, for regulatory ... the only laboratory licensed by the New Mexico Department ... order to meet the recently adopted regulatory requirements pertaining ...
(Date:2/26/2015)... TORONTO , Feb. 26, 2015 /PRNewswire/ - SQI ... SQIDF), a life sciences company that develops and commercializes ... reported its financial and operational results for the fiscal ... this press release are in Canadian dollars (CAD), unless ... Company continued to win new business from our existing ...
(Date:2/26/2015)... The Movement for Indefinite Life Extension (MILE) ... technologies and awareness. The event is taking place from ... 21st 2015, in a live Google Hangout broadcast from ... of MILE, says, “Our lives are in our hands, ... Indefinite Life Extension is raising awareness about bio-sciences and ...
(Date:2/26/2015)... February 26, 2015 The Pittcon ... at the Ernest N. Morial Convention Center in ... as of February 19, 2015) displaying products and ... academic, and government labs. The Exposition will offer ... not limited to, analytical chemistry; drug discovery; nanotechnology; ...
Breaking Biology Technology:Steep Hill First to Receive Provisional Approval to Establish Laboratory Services for Cannabis Testing in State of New Mexico 2SQI Diagnostics Reports First Quarter Financial Results 2SQI Diagnostics Reports First Quarter Financial Results 3SQI Diagnostics Reports First Quarter Financial Results 4SQI Diagnostics Reports First Quarter Financial Results 5SQI Diagnostics Reports First Quarter Financial Results 6Indefinite Life Extension Activists Organize Online Demonstration 2Indefinite Life Extension Activists Organize Online Demonstration 3Pittcon 2015 Announces Exposition Highlights 2
... -- Recently, academic debate has been swirling around the ... ubiquitous of phenomena, including photosynthesis, the process by which ... have suggested that entanglement (the quantum interconnection of two ... are separated in physical space) could be occurring in ...
... funding and has been hailed as ushering in the ... anticipated field, it has made its way into products ... and medications without much fanfare, while popular media ... Armageddon. Somewhere in between are social scientists, ethicists ...
... Novavax, Inc. (Nasdaq: NVAX ... Ph.D. to its board of directors.  Dr. Douglas is currently ... leader of Genzyme,s Corporate Development team, Dr. Douglas has been ... as well as Genzyme,s venture investments.  He has served in ...
Cached Biology Technology:New resource examines questions about the role of nanoscience 2NOVAVAX Elects Richard H. Douglas to its Board of Directors 2NOVAVAX Elects Richard H. Douglas to its Board of Directors 3
... part 11, Compliant software for JASCO HPLC systems. , Integrated ... EZChrom ... software options for JASCO HPLC systems. This provides a completely integrated ... instrument settings with each run. , ...
Rabbit anti Xanthine Oxidase Xanthine Oxidase, Bovine Buttermilk...
... Mass Spectrometry Applications ,In the age ... emerged as a powerful protein identification and ... is now an important intermediate step in ... to identification of specific proteins in the ...
... Extraction Reagent is a liquid, ... means no scraping, no freeze-thaw ... M-PER Reagent, rapid lysis occurs ... room temperature, yielding 25% more ...
Biology Products: