Navigation Links
Genes may determine success of hip replacement surgery

The success of long term hip replacement surgery may lie in the genes, suggests research published ahead of print in the Annals of the Rheumatic Diseases.

The researchers analysed genetic variations in 312 people, just over half of whom (162) had problems after hip replacement in the 10 years following surgery.

Among those with symptoms, 91 had early signs of “aseptic loosening,?which describes a condition in which the artificial joint comes loose and the surrounding bone begins to dissolve. The other 71 patients had deep-seated infection, which occurs when the body is unable to control infection caused by bacteria colonising the artificial implants.

DNA samples were taken from all participants to test for genetic variations in genes responsible for generating matrix metalloproteinase 1, or MMP1 for short, interleukin 6, and vitamin D synthesis.

MMP1 is an enzyme that breaks down collagen, the main protein found in bone and cartilage, while interleukin 6 is a chemical involved in bone metabolism and the immune response.

Vitamin D synthesis is important for strong healthy bones.

Variations in the interleukin 6 gene did not seem to have any effect. But those with variations in MMP1 were more than three times as likely to have aseptic loosening as those who did not carry the genetic variation.

And variations in the vitamin D receptor gene almost doubled the chances of bone dissolution and deep infection.

The authors conclude that if confirmed in other research, these findings could be used to predict long term success in patients undergoing hip replacement surgery. And they could also be used to develop targeted genetic treatments.

Source:BMJ-British Medical Journal

Page: 1

Related biology news :

1. Genes In The Interferon System Important In Systemic Lupus Erythematosus
2. Protein Packages Found To Activate Genes; May Be What Regulates Development And Disease
3. VCU Researchers Identify Networks Of Genes Responding To Alcohol In The Brain
4. Genpathway and Baylor College of Medicine Identify New Genes in Breast Cancer
5. Where Bacteria Get Their Genes
6. Genes linked to treatment resistance in children with leukemia
7. Noise And Delays Explain Why Some Genes Oscillate In Activity
8. Genes involved in biofilms
9. Genes involved in cell growth and cell division identified
10. Genes affecting blood pressure change as children become adults
11. Genes discovered that allow gum disease bacterium to invade arteries
Post Your Comments:

(Date:9/28/2015)... September 28, 2015 According to ... & Software), Product (Scanner & Others), Application (Access Control ... & Others) & Geography Global - Forecast to 2020", published ... reach USD 3627.90 Million by 2020, at a CAGR ... Browse 65 market data T ables and ...
(Date:9/26/2015)...  Results of a TactioRPM pilot project in ... the Stanford Medicine X Conference. In a presentation ... Health Devices and Pharmacogenomics", Roger Simard , ... how senior patients equipped with connected health devices ... the TactioRPM remote patient monitoring platform were empowered ...
(Date:9/24/2015)... , September 24, 2015 ... september 2015 Kerv ( ... finanstjänster, lanserar idag världens första kontaktlösa betalningsring ... in 77 000 GBP för massproduktion via ... ) , Kerv-bärare kan ...
Breaking Biology News(10 mins):
... part in the National Science Foundation,s (NSF) Faculty ... additional distinction as winners of Presidential Early Career ... 2006 competition. The PECASE program recognizes outstanding ... show exceptional potential for leadership at the frontiers ...
... wildfires can contribute as much as vehicles to carbon ... highly variable. New research published in the online open ... and suggests fires will complicate emissions monitoring and modelling ... Atmospheric Research and Jason Neff of the University of ...
... State University have designed a revolutionary laser technique which ... damaging human cells and may also help reduce the ... The research, published on Thursday November 1 in ... discusses how pulses from an infrared laser can be ...
Cached Biology News:
(Date:10/8/2015)... -- Celemics, a global pioneer of personalized medicine genetics, ... with the establishment of Celemics America, Inc. ... , has secured itself in the global market ... preparation for DNA sequencing and genetic testing.  Next Generation ... testing more accurately, quickly, and cost effectively than traditional ...
(Date:10/8/2015)... 2015 The 2015 Nobel Prize in Chemistry ... at Dallas. Aziz Sancar , who earned his PhD ... in 1977, is one of three scientists who received the ... repair damaged DNA on a molecular level.  --> Aziz ... from UT Dallas in 1977, is one ...
(Date:10/8/2015)... /PRNewswire/ - RepliCel Life Sciences Inc. (OTCQB: REPCF) (TSX.V: RP), ... development of autologous cell therapies, today announced its schedule of ... in the month of October: Stem Cell ... will be presenting at the annual Partnering Forum, part ... be held October 7-9 in La Jolla, ...
(Date:10/8/2015)... ... 2015 , ... Talon Innovations, a provider of Precision Machined Products ... it is one of three finalists for the Minnesota Business magazine’s Manufacturing Award in ... Talon Innovations was recognized as a nominee for this competitive award. , The ...
Breaking Biology Technology:
... DUBLIN , June 17, 2010 An ... hour blood,pressure is more accurate and consistent than a leading group of,international ... ... the study,analysed the interpretation of numerous blood pressure readings taken over a,24-hour ...
... becoming increasingly flatter - some have even become almost as ... dimensions, much to the delight of home cinema fans. Cellphones ... All of these developments owe their thanks to miniature light-emitting ... multitude of devices. However, LED technology does have a ...
... ... an occlusion-induced IR injury model enabling the ability to study the functional relevance of ... which the drug promotes myocardial protection. , ... (PRWEB) June 16, 2010 -- MD Biosciences , a ...
Cached Biology Technology: