Navigation Links
Genes linked to treatment resistance in children with leukemia

Today, the most common childhood cancer is cured in about 80 percent of patients; only forty years ago, this number was closer to five percent. In efforts to further increase the survival rate, researchers from St. Jude Children's Research Hospital, the University of Tennessee, and the University of Chicago studied how an individual's genetics might play a role in the effectiveness of chemotherapy drugs. Their findings will be published in the June 15, 2005, issue of Blood, the official journal of the American Society of Hematology.

The researchers studied 246 children with acute lymphoblastic leukemia (ALL), all of whom were assigned to one of two groups that determined the intensity of therapy. Patients with poorer prognostic factors ?130 children ?were assigned to a high-risk group; the remaining children were enrolled in the lower-risk arm.

In a process known as genotyping, DNA was extracted from the normal blood cells of each child and screened for sixteen common genetic variations. The studied genes code for enzymes which are involved in the metabolism and activity of chemotherapy drugs in the body, and were therefore likely to have effects on treatment outcomes.

In the analysis of the high-risk group, the GSTM1 non-null genotype was associated with hematological relapse, a recurrence of the cancer in the blood and bone marrow and the most common reason for treatment failure in childhood ALL. This risk was further increased if the child also had a TYMS 3/3 genotype. No genotype was associated with hematological relapse among patients in the lower-risk arm of the study.

The researchers also looked for evidence of leukemia in each patient's central nervous system (CNS), a region that is vulnerable to infiltration by cancer cells. Genetic variations may have particular impact on how drugs penetrate the "blood-brain" barrier that protects the CNS. For patients in the high-risk arm, the VDR FokI genotype was found to be prognostic for
'"/>

Source:American Society of Hematology


Page: 1 2

Related biology news :

1. Genes In The Interferon System Important In Systemic Lupus Erythematosus
2. Protein Packages Found To Activate Genes; May Be What Regulates Development And Disease
3. VCU Researchers Identify Networks Of Genes Responding To Alcohol In The Brain
4. Genpathway and Baylor College of Medicine Identify New Genes in Breast Cancer
5. Where Bacteria Get Their Genes
6. Noise And Delays Explain Why Some Genes Oscillate In Activity
7. Genes involved in biofilms
8. Genes involved in cell growth and cell division identified
9. Genes affecting blood pressure change as children become adults
10. Genes discovered that allow gum disease bacterium to invade arteries
11. Genes and genius: Researchers confirm association between gene and intelligence
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Genes linked treatment resistance children with leukemia

(Date:3/2/2015)... Calif. , March 2, 2015 ... leading developer of human interface solutions, today announced ... that is designed to enable rapid and secure ... ID™ module for gaming is a turnkey solution ... the ability to quickly integrate fingerprint ID solutions ...
(Date:3/2/2015)... 2015  Businesses have a new option for ... Rankins Enterprises has announced the launch of a ... for businesses to protect their customers, personal data, ... Beconux is a biometric transaction processing system ... to an ATM machine, the new system fuses ...
(Date:3/2/2015)...   Neurotechnology , a provider of high-precision biometric, ... Software Development Kit (SDK). The SentiGaze algorithm enables ... webcams to track eye movements and generate heatmaps based ... can be used for applications such as analysis of ... SDK can also be used to develop interfaces for ...
Breaking Biology News(10 mins):Synaptics Unveils New Fingerprint ID Solution for Gamers 2Synaptics Unveils New Fingerprint ID Solution for Gamers 3Personal Data Protection Company Launches New Product 2Neurotechnology Releases SentiGaze SDK for Eye Movement Tracking Using Ordinary Webcams 2Neurotechnology Releases SentiGaze SDK for Eye Movement Tracking Using Ordinary Webcams 3
... clean, local-source energy. Faster, more reliable technologies and ... Medical care tailored to your DNA, or neural ... and injuries. Five University of Pittsburgh faculty ... and technology as part of Faculty Early Career ...
... technology, researchers led by a Weill Cornell Medical College scientist ... about half of all prostate cancers. Estrogen-linked signaling helps ... by a chromosomal translocation, which in turn results in the ... cancers harbor a common recurrent gene fusion, and we believe ...
... life to thrive: temperature, or sunlight? The answer ... online this week in PNAS Early Edition, the explosion ... do with warmth than with light. The diversity ... strongly related to temperature, said University of Southern California ...
Cached Biology News:Pitt faculty receive awards to explore next-generation technologies 2Pitt faculty receive awards to explore next-generation technologies 3Pitt faculty receive awards to explore next-generation technologies 4Estrogen helps drive distinct, aggressive form of prostate cancer 2Estrogen helps drive distinct, aggressive form of prostate cancer 3What makes life go at the tropics? 2
(Date:3/3/2015)... (PRWEB) March 03, 2015 GlobalStemCellsGroup.com ... growing faculty. Camacho Alcocer, a biomedical researcher and founding ... will join GSCG’s team of biomedical professors who will ... program. , Criogenix SA de CV is a private ... Technological Institutions and Companies in Mexico (RENIECYT). , Camacho ...
(Date:3/3/2015)... -- Phillip Sharp, Institute Professor at the Massachusetts Institute of Technology ... the Koch Institute for Integrative Cancer Research, will receive the ... May 14, at the Chemical Heritage Foundation. Sharp is ... it was first awarded to Ralph Landau ... gave the scientific world a new view of the ...
(Date:3/2/2015)... 02, 2015 The American Society ... announced today the launch of Genetically Speaking , ... professionals on the application of human genetics in disease ... peer-to-peer interviews conducted during the ASHG 2014 Annual Meeting ... Genomics and Health Outcomes Research: What's Ready for Primetime? ...
(Date:3/2/2015)... Md. (PRWEB) March 02, 2015 Shimadzu ... sessions and present on LCMS and marijuana analysis at ... place March 8 to 12 at the Ernest N. ... Attendees can stop by booth 3121 to discuss laboratory ... the company’s innovative, proven products help save time, money ...
Breaking Biology Technology:Mario Camacho Alcocer Joins Global Stem Cells Group Faculty 2Mario Camacho Alcocer Joins Global Stem Cells Group Faculty 3Phillip Sharp to Receive 2015 Othmer Gold Medal 2Phillip Sharp to Receive 2015 Othmer Gold Medal 3American Society of Human Genetics (ASHG) and ReachMD Launch Series on Genetics and Genomics 2American Society of Human Genetics (ASHG) and ReachMD Launch Series on Genetics and Genomics 3Shimadzu Scientific Instruments Announces Product Launches, Presentations and Poster Sessions for Pittcon 2015 2Shimadzu Scientific Instruments Announces Product Launches, Presentations and Poster Sessions for Pittcon 2015 3
... Marinus Pharmaceuticals, a,developer of specialty therapeutics to treat ... Krayacich as president,and chief executive officer. Mr. Krayacich ... business development for ganaxolone, an adult and,pediatric epilepsy ... candidate., Mr. Krayacich brings more than 20 ...
... (Amex: NBS ),announced today that the new Southern Florida ... Miami, is targeted to open in,September. The center is being ... of this center, NeoStem has secured a key geographic,stronghold in ... as well as a,growing sophisticated South American presence., Chester ...
... Company hits key insulin and Apo AI(Milano), ... 5 /PRNewswire-FirstCall/ - SemBioSys Genetics Inc.,(TSX:SBS), a biotechnology ... and cardiovascular diseases, today announced its,2008 second quarter ... Insulin Program, - Submitted an ...
Cached Biology Technology:Marinus Pharmaceuticals Appoints John Krayacich as President and Chief Executive Officer 2Marinus Pharmaceuticals Appoints John Krayacich as President and Chief Executive Officer 3Marinus Pharmaceuticals Appoints John Krayacich as President and Chief Executive Officer 4NeoStem Forges Ahead in Its Plan to Open Adult Stem Cell Collection Centers in Key Locations that Can Serve as Hubs to Service Clients Nationwide 2NeoStem Forges Ahead in Its Plan to Open Adult Stem Cell Collection Centers in Key Locations that Can Serve as Hubs to Service Clients Nationwide 3SemBioSys announces second quarter 2008 financial and operational results 2SemBioSys announces second quarter 2008 financial and operational results 3SemBioSys announces second quarter 2008 financial and operational results 4SemBioSys announces second quarter 2008 financial and operational results 5SemBioSys announces second quarter 2008 financial and operational results 6SemBioSys announces second quarter 2008 financial and operational results 7SemBioSys announces second quarter 2008 financial and operational results 8SemBioSys announces second quarter 2008 financial and operational results 9SemBioSys announces second quarter 2008 financial and operational results 10SemBioSys announces second quarter 2008 financial and operational results 11SemBioSys announces second quarter 2008 financial and operational results 12SemBioSys announces second quarter 2008 financial and operational results 13
... (Ser385) Immunogen: ... acid region encompassing the human, ... Accession Number: ... Quality Assurance: Routinely evaluated ...
Mouse monoclonal [MN-8C4] to zona radiata ( Abpromise for all tested applications). Antigen: Purified eggshell proteins (zona radiata proteins and small amounts of zona pellucida proteins) from ...
CCNI Antibody...
...
Biology Products: