Navigation Links
Genes linked to treatment resistance in children with leukemia

Today, the most common childhood cancer is cured in about 80 percent of patients; only forty years ago, this number was closer to five percent. In efforts to further increase the survival rate, researchers from St. Jude Children's Research Hospital, the University of Tennessee, and the University of Chicago studied how an individual's genetics might play a role in the effectiveness of chemotherapy drugs. Their findings will be published in the June 15, 2005, issue of Blood, the official journal of the American Society of Hematology.

The researchers studied 246 children with acute lymphoblastic leukemia (ALL), all of whom were assigned to one of two groups that determined the intensity of therapy. Patients with poorer prognostic factors ?130 children ?were assigned to a high-risk group; the remaining children were enrolled in the lower-risk arm.

In a process known as genotyping, DNA was extracted from the normal blood cells of each child and screened for sixteen common genetic variations. The studied genes code for enzymes which are involved in the metabolism and activity of chemotherapy drugs in the body, and were therefore likely to have effects on treatment outcomes.

In the analysis of the high-risk group, the GSTM1 non-null genotype was associated with hematological relapse, a recurrence of the cancer in the blood and bone marrow and the most common reason for treatment failure in childhood ALL. This risk was further increased if the child also had a TYMS 3/3 genotype. No genotype was associated with hematological relapse among patients in the lower-risk arm of the study.

The researchers also looked for evidence of leukemia in each patient's central nervous system (CNS), a region that is vulnerable to infiltration by cancer cells. Genetic variations may have particular impact on how drugs penetrate the "blood-brain" barrier that protects the CNS. For patients in the high-risk arm, the VDR FokI genotype was found to be prognostic for
'"/>

Source:American Society of Hematology


Page: 1 2

Related biology news :

1. Genes In The Interferon System Important In Systemic Lupus Erythematosus
2. Protein Packages Found To Activate Genes; May Be What Regulates Development And Disease
3. VCU Researchers Identify Networks Of Genes Responding To Alcohol In The Brain
4. Genpathway and Baylor College of Medicine Identify New Genes in Breast Cancer
5. Where Bacteria Get Their Genes
6. Noise And Delays Explain Why Some Genes Oscillate In Activity
7. Genes involved in biofilms
8. Genes involved in cell growth and cell division identified
9. Genes affecting blood pressure change as children become adults
10. Genes discovered that allow gum disease bacterium to invade arteries
11. Genes and genius: Researchers confirm association between gene and intelligence
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Genes linked treatment resistance children with leukemia

(Date:4/23/2014)... TX (4/23/14) -- Researchers have found evidence of ... factors that increase aggressive behavior in children, especially ... not all children exposed to prenatal smoking will ... will not," said Brian Boutwell, Assistant Professor at ... and senior author on the study. "One ...
(Date:4/23/2014)... away from using triclosan as an antimicrobial ingredient in ... now scientists are reporting new evidence that appears to ... journal Chemical Research in Toxicology , found that ... promoted the growth of human breast cancer cells in ... Kyung-Chul Choi and colleagues note that hormonal imbalances seem ...
(Date:4/23/2014)... comprehensive study to date of the family of ... effective vaccine strategies and reveals surprising findings about ... could alter public health strategies to control this ... year. , Genomic analysis of 343 strains of ... the world collected over the last 100 years ...
Breaking Biology News(10 mins):Genetics risk, prenatal smoking may predict behavioral problems 2In lab tests, the antimicrobial ingredient triclosan spurs growth of breast cancer cells 2Impact of whooping cough vaccination revealed 2
... Scheduling more physical education time in schools does not ... research that discovered those who got lots of timetabled ... while those who got little at school made up ... The scientists, who presented their research Thursday at the ...
... Inc. (Nasdaq: AWRE ), a leading supplier of ... its first quarter ended March 31, 2009. Revenues for ... of 22% compared to $5.9 million in the same quarter ... and diluted net income per share in accordance with U.S. ...
... Desert environments are characterized by poor vegetative cover, ... conditions. In this context, the land resources of ... are subjected to various land degradation stresses, including ... sustain the land resources of Abu Dhabi Emirate, ...
Cached Biology News:Study finds children's activity levels not influenced by more PE time in school 2Aware, Inc. Reports First Quarter 2009 Financial Results 2Aware, Inc. Reports First Quarter 2009 Financial Results 3Aware, Inc. Reports First Quarter 2009 Financial Results 4Aware, Inc. Reports First Quarter 2009 Financial Results 5Aware, Inc. Reports First Quarter 2009 Financial Results 6Wind, salt and water are leading indicators of land degradation in Abu Dhabi 2
(Date:1/14/2014)... EquitiesIQ, a leading informational research provider, has ... an emerging biomedical company acquiring, developing, manufacturing, and marketing ... Free report download: http://equitiesiq.com/reports/alliqua/ , In late ... and Board, which launched the company’s new strategy to ...
(Date:1/14/2014)... January 14, 2014 In recent years, ... and methods in product development and promotion has led ... This mistrust, fueled by concerns about the insidious impact ... reports of spectacular fines to the world’s biggest pharmas ...
(Date:1/14/2014)... Cardiff, UK (PRWEB) January 13, 2014 ... leader with more than 20 years in the industry, ... and photonics . Hainsey will serve as the society’s ... have Dr. Hainsey join SPIE as our Technology Strategist, ...
(Date:1/14/2014)... Triangle Park, NC (PRWEB) January 14, 2014 ... company focusing on ultra-sensitive POC diagnostic platforms and novel disease ... their first round of financing netting a total of $690,000. ... outside equity capital in the company. This group of private ...
Breaking Biology Technology:EquitiesIQ Initiates Coverage of Alliqua, Inc. 2EquitiesIQ Initiates Coverage of Alliqua, Inc. 3The Sunshine Act: Necessary Regulation or Unnecessary Dysregulation? New Life Science Webinar Hosted by Xtalks and IRB Services 2The Sunshine Act: Necessary Regulation or Unnecessary Dysregulation? New Life Science Webinar Hosted by Xtalks and IRB Services 3Photonics R&D Leader Bob Hainsey Joins SPIE Technical Staff 2BioMedomics, Inc. Closes $690K Round of Financing 2
... Focus on Critical Industry Issues -- DUBAI, UAE, September 8, 2010 ... ... ... keyed by longUrl, so we need to grab the first one. for (var r in data.results) { first_result ...
... YORK, Sept. 7 Reportlinker.com announces that a ... catalogue: Biotechnology Pharmaceutical Market in ... Biotechnology Pharmaceutical Market in US ... Pharmaceutical market to grow at a CAGR of ...
... Inc. (OTC Bulletin Board: FCSC ), a ... therapies for aesthetic, medical and scientific applications, announced today ... to its scientific advisory board. In addition to being ... a biotechnology and genetic research expert. Dr. Gruenwald also ...
Cached Biology Technology:Cold Chain MENA 2010 to Focus on Critical Industry Issues 2Cold Chain MENA 2010 to Focus on Critical Industry Issues 3Cold Chain MENA 2010 to Focus on Critical Industry Issues 4Cold Chain MENA 2010 to Focus on Critical Industry Issues 5Cold Chain MENA 2010 to Focus on Critical Industry Issues 6Reportlinker Adds Biotechnology Pharmaceutical Market in US -2013 2Fibrocell Science, Inc. Names Biotechnology and Genetic Research Expert Stefan Gruenwald, M.D., Ph.D., to Scientific Advisory Board 2Fibrocell Science, Inc. Names Biotechnology and Genetic Research Expert Stefan Gruenwald, M.D., Ph.D., to Scientific Advisory Board 3
...
Human Cystatin A MAb (Clone 224705)...
Corticoliberin...
Anti-SDF-1β/PBSF affinity isolated antibody lyophilized powder Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline recombinant human SDF-1β/PBSF expressed in E....
Biology Products: