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Genes and biomarkers that allow doctors to choose the right therapy for the right patient

ity, which appears through a variety of forms including rashes, eczema and fissures. Skin toxicity also indicates a poor response to cetuximab. The study indicated that median survival is 15.6 months for patients with skin toxicity and without a KRAS mutation; whereas the survival is only 5.6 months for patients with the mutation, but no skin toxicity.

Dr. Laurent-Puig and colleagues are continuing to investigate the molecular biomarkers associated with cetuximab, including in tumors without the KRAS mutation that do not respond to the drug.

Recombinant peptides as biomarkers for cancer response to tyrosine kinase inhibitors combined with radiation: Abstract 4657

A new method for determining biomarkers could allow physicians to personalize lung or brain cancer therapy and lower the risk of unnecessary radiation treatments. Researchers at Vanderbilt University are using a biomarker library of peptides to determine whether or not tyrosine kinase inhibitor therapy, combined with radiation therapy, is indeed effective against lung or brain cancer.

"It is difficult to assess the response of cancer in the brain or lung to treatment, since those neoplasms are difficult to access safely," said Roberto Diaz, M.D., Ph.D., a resident in Radiation Oncology at the Vanderbilt-Ingram Cancer Center. "With the proper biomarkers physicians may be able to tell if a patient is not responding to the therapy and alter their treatment strategy accordingly."

The researchers screened lung and brain tumors to determine which peptides ?or protein fragments ?were active in the tissue environment surrounding the tumors. This phage displayed library ?called so after the bacteriophage viruses used to capture protein fragments ?was then isolated and tested.

With the library, Dr. Diaz and his colleagues could select peptides that bind to tumors that are affected by a combination of radiation and tyrosine kinase inhibitor the
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Source:American Association for Cancer Research


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