Navigation Links
Genes and biomarkers that allow doctors to choose the right therapy for the right patient

that represent the subtypes observed in analyses of primary tumors.

By correlating the responses of these cells to targeted therapeutic drugs, the researchers were able to identify the molecular characteristics of cells that were most sensitive to the drugs. They tested their approach by analyzing responses of the cell line panel to lapatinib, a duel inhibitor of EGFR and ErbB2 and CI-1040, a MEK enzyme inhibitor. These studies defined molecular signatures that predicted individual responses among the cell lines to the drugs. For Lapatinib, the strongest correlate of response was amplification and over expression of ErBB2, consistent with clinical experience. For CI-1040, changes in the MEK pathway were most strongly associated with response. Predictors based on combinations of molecular correlates of response were able to quantitatively predict individual cell line responses.

"The concordance of our markers of response to lapatinib with those observed clinically suggests that the molecular markers identified in the cell line collection can be used to guide the use and testing of other approved and experimental drugs," Gray said. "This is important since it is logistically and financially impossible to test all of the experimental medicines in each cancer subtype. This ‘systems?approach suggests a way to prioritize drugs for use in patients and for initial clinical tests."

According to Gray, a large of number of emerging therapeutic agents should be prioritized for testing in the subtypes of breast cancer along with other cancers and their subtypes. When therapies are ineffective, they may produce harmful side effects and decrease a patient’s quality of life.

KRAS mutation in colorectal cancer is a predictive factor of response and progression free survival in patients treated with Cetuximab: Abstract 5671

Mutations in the KRAS oncogene could predict a lack of response to the drug cetuximab in patie
'"/>

Source:American Association for Cancer Research


Page: 1 2 3 4 5 6

Related biology news :

1. Genes In The Interferon System Important In Systemic Lupus Erythematosus
2. Protein Packages Found To Activate Genes; May Be What Regulates Development And Disease
3. VCU Researchers Identify Networks Of Genes Responding To Alcohol In The Brain
4. Genpathway and Baylor College of Medicine Identify New Genes in Breast Cancer
5. Where Bacteria Get Their Genes
6. Genes linked to treatment resistance in children with leukemia
7. Noise And Delays Explain Why Some Genes Oscillate In Activity
8. Genes involved in biofilms
9. Genes involved in cell growth and cell division identified
10. Genes affecting blood pressure change as children become adults
11. Genes discovered that allow gum disease bacterium to invade arteries
Post Your Comments:
(Date:9/23/2014)... years, man has domesticated animals, selecting the best ... sheep offer an intriguing animal to examine adaptation ... centuries of selected breeding and a wealth of ... first-of-its kind study that combined molecular and environmental ... search for genes under environmental selection from domesticated ...
(Date:9/23/2014)... oil sands tailings has just gotten a lot greener ... Alberta civil engineering professors that uses solar energy to ... of using UV lamps as a light source to ... tailings ponds, professors Mohamed Gamal El-Din and James Bolton ... energy source treats the wastewater just as efficiently but ...
(Date:9/23/2014)... A multidisciplinary team at the University of Wisconsin-Madison and ... more affordable way to screen for neural toxins, helping ... National Institutes of Health (NIH) announced today that the ... support to continue the promising work as part of ... will receive approximately $7 million over the three-year project. ...
Breaking Biology News(10 mins):Being sheepish about climate adaptation 2Solar energy-driven process could revolutionize oil sands tailings reclamation 2UW-Madison team developing 'tissue chip' to screen neurological toxins 2UW-Madison team developing 'tissue chip' to screen neurological toxins 3
... (OSCC) is responsible for nearly a quarter of all head ... of cancer death - largely due to the failure of ... New research published in BioMed Central,s open access journal ... predict which patients are at higher risk of OSCC recurrence. ...
... at the University of York and Hull York Medical ... the brain is affected by age. Working with ... in Plymouth, they have studied responses to stress in ... that under stressful conditions, such as neuro-degeneration, resulting high ...
... a key role in turning off disease? Researchers ... a biosensor they,ve created that measures membrane lipid levels may ... distinguished professor of chemistry, and his coworkers engineered a way ... lipid levels. Their findings are reported in Nature ...
Cached Biology News:Researchers study aging's effect on the brain 2New membrane lipid measuring technique may help fight disease 2
(Date:9/23/2014)... This is a professional and ... Isopropanol (IPA) industry. The report provides a basic ... industry chain structure. Global market analysis and Chinese ... on history, developments, trends and competitive landscape of ... Chinese situation is also offered. , The report ...
(Date:9/23/2014)... 23, 2014 Marktech Optoelectronics has introduced ... violet emitters in the 280 nm wavelength range. This ... which range from 280nm to 405nm. These new devices ... as well as curing. Mark Campito, Marktech’s CEO states ... interest to manufacturers is that we offer it in ...
(Date:9/22/2014)... treated with a statin in the hospital after suffering ... survive than those who were not, according to a ... study was conducted by the same researchers who recently ... survival in victims of ischemic stroke., Ischemic stroke is ... vessel that blocks blood from reaching areas of the ...
(Date:9/22/2014)... fragments whose job it is to stop bleeding, are ... they can "feel" the physical environment around them, researchers ... respond to surfaces with greater stiffness by increasing their ... platelets and other components of the clotting system, the ... them credit for, in that they are able to ...
Breaking Biology Technology:(IPA) Isopropanol Industry International & China Development Trend Analysis Now Available at DeepResearchReports.com 2(IPA) Isopropanol Industry International & China Development Trend Analysis Now Available at DeepResearchReports.com 3Marktech Introduces its New Line of Deep UV Emitters 2Statin use during hospitalization for hemorrhagic stroke associated with improved survival 2Platelets modulate clotting behavior by 'feeling' their surroundings 2
... - With Sony set to take over Sonic Foundrys desktop ... go from here? Two words: Mediasite Live. , ,Sonic ... audio conferencing market by enhancing web conferencing with Mediasite Live. ... great opportunity for the company to go forward because there ...
... stream video from their Charleston and Morgantown campuses so students ... All of WVUs core graduate nursing school courses will be ... ,We need more nurses and we need more nurse educators ... professor of nursing at WVU School of Nursing. By using ...
... better drugs, faster part of the speech. Thats where the ... is likely to hit the road, especially as the largest ... become as common in conversation as golf games and grandkids. ... Vodenlich joined as president earlier this year, recently restructured its ...
Cached Biology Technology:Sonic Foundry: What's Next? 2Sonic Foundry Facilitates Nursing Education 2Sonic Foundry Facilitates Nursing Education 3Chipping Away at Drug Development 2Chipping Away at Drug Development 3
Puromycin resistance gene (pac), provided in a pORF plasmid. pORF is an expression plasmid selectable with Ampicillin....
Plasmid expressing Zeocin resistance gene....
...
... template is designed to allow kanamycin/neomycin ... It combines a prokaryotic promoter (gb2) ... E.coli with a eukaryotic promoter (PGK) ... cells. The prokaryotic promoter gb2 is ...
Biology Products: