Navigation Links
Genes In The Interferon System Important In Systemic Lupus Erythematosus

Two genes with very strong associations with the disease systemic lupus erythematosus (SLE) have been identified by a team of scientists headed by researchers at the Department of Medical Sciences at Uppsala University. The findings are being published today on the Web page of the highly prestigious American Journal of Human Genetics. "These findings are probably the first genetic pieces of a huge 'interferon puzzle,' with whose help it will be possible to discover the mechanisms behind the disease SLE, and maybe other autoimmune diseases at the molecular level," says Professor Lars Rönnblom.

"It is remarkable that by studying only eleven of the some 200 genes that are seen as belonging to the interferon system, we were able to identify two genes with such clear connection to SLE," says Professor Ann-Christine Syvänen. A few years ago Lars Rönnblom and Professor Gunnar Alm at the Swedish University of Agricultural Sciences were virtually the only researchers who claimed that the interferon system, which is involved in the body's defense against viruses, etc., was also behind the autoimmune disease SLE. Since then they have shown the importance of the interferon system in a number of works. This has led to the recognition of their hypothesis in the last year, and today it represents a white-hot field of research that has attracted a great deal of interest in the pharmaceutical industry. This picture has now been further reinforced by new findings­ - the result of multidisciplinary and international collaboration involving world experts on the interferon system, immunology, and the disease SLE, combined with world leaders in the technology for large-scale genetic analyses and statistics. The genetic and statistical analyses were performed by the doctoral student Snaevar Sigurdsson and Professor Ann-Christine Syvänen at the Center for Clinical Medical Research at Uppsala University. The study, comprising nearly 2,000 individuals, shows that two genes in the inte
'"/>

Source:Science Daily


Page: 1 2

Related biology news :

1. Protein Packages Found To Activate Genes; May Be What Regulates Development And Disease
2. VCU Researchers Identify Networks Of Genes Responding To Alcohol In The Brain
3. Genpathway and Baylor College of Medicine Identify New Genes in Breast Cancer
4. Where Bacteria Get Their Genes
5. Genes linked to treatment resistance in children with leukemia
6. Noise And Delays Explain Why Some Genes Oscillate In Activity
7. Genes involved in biofilms
8. Genes involved in cell growth and cell division identified
9. Genes affecting blood pressure change as children become adults
10. Genes discovered that allow gum disease bacterium to invade arteries
11. Genes and genius: Researchers confirm association between gene and intelligence
Post Your Comments:
(Date:7/24/2014)... -- Keryx Biopharmaceuticals, Inc. (Nasdaq:KERX) (the "Company") announced the ... Phase 3 study of Zerenex (ferric citrate), the Company,s ... of hyperphosphatemia in patients with end-stage renal disease (ESRD) ... delivery with FErric CiTrate in EsrD) was published online ... of Nephrology ( JASN ). , ...
(Date:7/24/2014)... have decreased by 45% on average over a 35 ... a study on the impact of humans on declining ... benefits invertebrates such as insects, spiders, crustaceans, slugs and ... pest control for crops, decomposition for nutrient cycling, water ... Science and led by UCL, Stanford and ...
(Date:7/24/2014)... 3.5 billion years of evolutionary trial and error, is ... may be reaching a tipping point. , In a ... published in Science , an international team of ... is contributing to what appears to be the early ... , Since 1500, more than 320 terrestrial vertebrates have ...
Breaking Biology News(10 mins):Zerenex™ (ferric citrate) long-term Phase 3 study results published in JASN 2Zerenex™ (ferric citrate) long-term Phase 3 study results published in JASN 3Zerenex™ (ferric citrate) long-term Phase 3 study results published in JASN 4Invertebrate numbers nearly halve as human population doubles 2Invertebrate numbers nearly halve as human population doubles 3Stanford biologist warns of early stages of Earth's 6th mass extinction event 2Stanford biologist warns of early stages of Earth's 6th mass extinction event 3
... of the body, the great majority of genes are silenced, ... up chromosomes. Estimates are that only about 10 percent of ... or "on," at any given time in a particular cell ... , Reliable gene silencing is vital to the health of ...
... have discovered a gene in fruit flies that helps ... The study, published in the April 4 issue of ... in mammals. , In teasing apart the molecular interactions ... gene they dubbed "Lazaro" that is expressed 15 times ...
... industry, including cruise lines, local governments and shore ... are taking proactive measures to ensure a sustainable ... according to a new report titled From Ship ... by Conservation International's (CI) Center for Environmental Leadership ...
Cached Biology News:New mechanism for essential genome-wide gene silencing identified 2New gene reduces retinal degeneration in fruit flies 2Report finds cruise industry is protecting the precious places it visits 2Report finds cruise industry is protecting the precious places it visits 3Report finds cruise industry is protecting the precious places it visits 4
(Date:7/25/2014)... 25, 2014  Galmed Pharmaceuticals Ltd. (Nasdaq: ... the development and commercialization of a once-daily, oral therapy ... today announced financial results for the period ended June ... , Reported cash and cash equivalents totaling $37.4 ... December 31, 2013.  , Reported a net loss ...
(Date:7/25/2014)... July 25, 2014 Sinovac Biotech Ltd. (Nasdaq: ... China , today announced that it will ... June 30, 2014, after market close on Thursday, August 14, ... to the market opening on Friday, August 15, 2014, at ... China Standard Time) to review the Company,s financial results and ...
(Date:7/24/2014)... 2014 Gain recognition for leadership ... of the biotech industry. Nominations are now being ... to you by the Bio Supply Management ... chain management professionals for the past 7 years. ... the Biotech industry – Manufacturers, Service Providers, Material ...
(Date:7/24/2014)... 24, 2014  ECC West Africa, LLC (ECC) signed ... with University College Hospital (UCH) Ibadan Board of Management ... finance, design, construct, and operate and maintain a new, ... . Under the first of the 4-phase project, ECC ... funding applications. UCH Ibadan intends to finance and develop ...
Breaking Biology Technology:Galmed Pharmaceuticals Reports First Half 2014 Financial Results 2Galmed Pharmaceuticals Reports First Half 2014 Financial Results 3Galmed Pharmaceuticals Reports First Half 2014 Financial Results 4Galmed Pharmaceuticals Reports First Half 2014 Financial Results 5Galmed Pharmaceuticals Reports First Half 2014 Financial Results 6Sinovac to Host Conference Call to Report Second Quarter 2014 Unaudited Financial Results 2Call for Submission: BSMA’s Supply Chain Management Innovation Awards 2Call for Submission: BSMA’s Supply Chain Management Innovation Awards 3ECC Signs a Contract for the Finance, Design, and Construction of a Premier Cancer Institute in Ibadan, Nigeria 2
... caused by mutations in the gene responsible for making ... and developing new therapies has been hampered by the ... fail to develop many of the symptoms seen in ... April issue of the Journal of Clinical Investigation have ...
... 6 /Xinhua-PRNewswire-FirstCall/ -- Pharmaxis,(ASX: PXS; Nasdaq: PXSL) today ... treat bronchiectasis has been accepted for evaluation by,China,s ... pharmaceutical companies are required to undertake a study ... application.,Approval of the clinical trial application is expected ...
... PALO ALTO, Calif., March 6 Jazz,Pharmaceuticals, Inc. ... the,public to a live webcast of the company,s ... 10:00 a.m. Eastern Time/7:00 a.m.,Pacific Time on Thursday, ... last,approximately two hours., Members of Jazz Pharmaceuticals, ...
Cached Biology Technology:Pharmaxis' First Steps into China 2
...
Goat polyclonal to Rabenosyn 5 ( Abpromise for all tested applications). Antigen: Synthetic peptide: ELKHTLAKQKGGTD, corresponding to C terminal amino acids 771-784 of Human Rabenosyn 5. Entr...
... ( Abpromise for all tested ... Synthetic peptide derived from residues 231 ... (Note: the amino acid sequence is ... Entrez Gene ID: 80829 ...
Anti-Salmonid Ig (H), Alk Phos, (Clone IPA5F12) (mouse IgG2a)...
Biology Products: