Navigation Links
Gene variations explain drug dose required to control seizures

elative safety for a particular treatment.

Similarly, appropriate doses of carbamazepine take time to determine because of the drug's variable affects on patient metabolism and its potential neurologic side effects.

The team identified genes considered to be obvious candidates underlying patients' drug response, based on their known roles in the metabolism or transport of one or both anti-epileptic drugs. In 425 epileptic patients taking carbamazepine and 281 taking phenytoin, the researchers then searched for an association between clinical use of the drugs and variation in the candidate genes.

One variant of a gene known as CYP2C9, which encodes a liver enzyme involved in drug metabolism, showed a significant association with the maximum dose of phenytoin taken by patients with epilepsy.

Moreover, a variant of a second gene, called SCN1A, with activity in the brain, was found significantly more often in patients on the highest doses of both carbamazepine and phenytoin. SCN1A has been implicated in many inherited forms of epilepsy and is the drug target for phenytoin.

Given its relationship to both anti-epileptic drugs tested, the SCN1A variant may be of particular importance for understanding patient response to drug treatment, said the researchers, noting that many other anti-epilepsy drugs act on related brain proteins.

"The range of doses taken by patients at epilepsy clinics is great," Goldstein said. "For someone at the higher end, it can take months to get their seizures under control. This study uncovers factors that might determine, in advance, which patients will need the higher dose."

Before any such pharmacogenetic approaches can be put into practice, they must be explicitly evaluated for clinical utility in improving patient outcomes, Goldstein said.

The new findings provide a direction for a dosing scheme that could be tested in the clinic to assess whether pharmacogenetic diagnostics can
'"/>

Source:Duke University Medical Center


Page: 1 2 3 4

Related biology news :

1. Researchers map of genetic variations implicated in disease
2. A new kind of mutation could explain numerous phenotypic variations in various species
3. Gene variations contribute to aggression and anger in women
4. Jumping gene helps explain immune systems abilities
5. Gene sequencing explains bioremediation bug
6. Variation in womens X chromosomes may explain differences among individuals, between sexes
7. Iron exporter revealed that may explain common human disorder
8. New book explains antibiotic resistance for a broad audience
9. Cats indifference towards sugar explained
10. Monkeypox mystery: New research may explain why 2003 outbreak in the US wasnt deadly
11. Scientist uses form to explain function of key building blocks of life
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Gene variations explain drug dose required control seizures

(Date:7/11/2014)... division of the striatum is also involved in ... of substance P in the striatal marginal division ... his team, College of Biophotonics, South China Normal ... P receptor, neurokinin 1 was highly expressed in ... rats. Unilateral or bilateral injection of an antisense ...
(Date:7/11/2014)... -- Research and Markets has announced the ... Industry Analysis Size Share Growth Trends and Forecast to ... http://photos.prnewswire.com/prnh/20130307/600769 The rising number ... for high level security in both private and public ... username and passwords, tokens etc. are vulnerable to attacks. ...
(Date:7/10/2014)... in New Mexico, nearly every public golf course is ... potable water supplies. Across the U.S. Southwest as a ... treated effluent. Reusing the effluent increases the sustainability of ... alike fertilize their lawns during the growing season. The ... State University turfgrass expert has a new vision for ...
Breaking Biology News(10 mins):International Biometrics Technology Market - Industry Analysis Size Share Growth Trends and Forecast to 2019 2'Tailored' water -- the latest in lawn care 2
... biologist at Fred Hutchinson Cancer Research Center, has received the ... Pfizer Inc., the award consists of a $25,000 prize in ... , She was among 18 honored by NAS this year ... the physical, biological and social sciences. , Biggins, a ...
... LA JOLLA, CA January 8, 2013 - Chemists at The ... one of the most fundamental tasks in molecular biology. Their new ... that these cells may be easily located and/or selected out from ... in a recent issue of the chemistry journal Angewandte Chemie ...
... Qubcois en Reproduction (RQR), Palais des congrs de Montral, Montral, ... Submissions: 15 February 2013 -- The Society for the ... for presentation at the 46th SSR Annual Meeting to be ... visit the SSR Meetings page ( http://www.ssr.org/Meetings.shtml ) for details; ...
Cached Biology News:National Academy of Sciences honors geneticist and biologist Sue Biggins 2Chemists devise inexpensive, benchtop method for marking and selecting cells 2Chemists devise inexpensive, benchtop method for marking and selecting cells 3
(Date:7/10/2014)... 10, 2014 Terascala, the industry leader ... Alan Swahn, a former vice president of product management ... vice president of marketing. Terascala’s software when combined with ... create the highest performance and most reliable solutions for ... guide Terascala’s channel expansion and broaden its product portfolio. ...
(Date:7/10/2014)... 2014 Robert Harman, DVM, Founder and CEO ... proud to announce the relaunch of his highly informative blog, ... series called “ What are Stem Cells ?” Dr. ... straightforward foundation in the basics of stem cell therapy so ... right type of treatment when considering regenerative medicine. , A ...
(Date:7/10/2014)... 10, 2014 EvoDerma ’s NOOME Anti-Aging ... rejuvenating device now comes with a second treatment cup to ... , The new cup is thinner on the edges for ... target rough, thin and uneven surfaces on the face, neck ... a stimulating treatment on areas such as the cheeks and ...
(Date:7/10/2014)... 10, 2014  Franciscan St. Anthony Health-Crown ... for respiratory monitoring outside the operating room, ... in embracing state-of-the-art patient safety technology. ... breathing and can alert medical caregivers when ... amount of carbon dioxide the patient is ...
Breaking Biology Technology:Terascala Expands Executive Team 2Terascala Expands Executive Team 3Robert Harman, DVM Talks About What Stem Cells are in His Latest Blog Series for Vet-Stem, Inc. 2Robert Harman, DVM Talks About What Stem Cells are in His Latest Blog Series for Vet-Stem, Inc. 3Introducing a New Bonus Treatment Cup for EvoDerma’s NOOME Anti-Aging Motion 2Franciscan St. Anthony Health-Crown Point Underscores Patient Safety Commitment Through Expanded Use of Capnography 2
... To thrive in today,s,competitive and changing marketplace, sales ... performance doesn,t just happen. Productive,companies train, structure, deploy, ... field-performance to ensure high success rates., Best ... their sales forces to evolve and mature to ...
... Part Of Georgetown University Hospital Arsenal Against ... ... Sciences (OTC,Bulletin Board: DSCI), a provider of advanced wound care products,announced ... Leptospermum Honey, has been used by clinicians at Georgetown,University Hospital,s Wound ...
... Danube Pharmaceuticals, Inc., a,privately held biopharmaceutical company ... drugs for ophthalmology, is pleased,to announce the appointment ... Chief,Executive Officer., "I am honored and delighted ... its history as it advances its lead programs ...
Cached Biology Technology:Increasing Sales Productivity Through Superior Sales Force Performance Management 2Derma Sciences MEDIHONEY(TM) Helps to Save Patient's Limb 2Derma Sciences MEDIHONEY(TM) Helps to Save Patient's Limb 3Derma Sciences MEDIHONEY(TM) Helps to Save Patient's Limb 4Barrett Katz, MD, MBA, Named CEO of Danube Pharmaceuticals 2Barrett Katz, MD, MBA, Named CEO of Danube Pharmaceuticals 3
Donor feline serum and plasma...
8 different frozen tissues are mounted on positively charged glass slides...
... cups provide flexible sealing lips for ... surfaces. ,PFG: Flat cup ,PBG: Bellows ... Multiple Bellows cup , Range ... 200 mm , Multiple suction cup ...
XA7 B6...
Biology Products: