Navigation Links
Gene variation affects tamoxifen's benefit for breast cancer

tended to be less severe, suggesting that this side effect could predict the gene variation.

Further studies are needed, but researchers hope one day this finding may lead to a genetic test that could help doctors determine which women are most likely to benefit from tamoxifen. This type of test is not currently offered clinically.

Rae and Daniel F. Hayes, M.D., director of breast oncology at the U-M Comprehensive Cancer Center, are part of the Pharmacogenetics Research Network, a multidisciplinary research group conducting a prospective clinical trial to confirm whether genetic testing can be used to identify patients likely to respond to endocrine therapy, including tamoxifen. This group is led by David A Flockhart, M.D., Ph.D. at Indiana University School of Medicine.

More than 210,000 women in the United States will develop breast cancer. Approximately 70 percent of these cancers are fueled by estrogen, many of which are treated with tamoxifen, a drug designed to block the effects of estrogen in breast tissue. The findings from this trial were derived from a large North Central Cancer Treatment Group study in which women were treated with tamoxifen, a pill that is taken daily, for a total of five years.

Additional authors included the following researchers from the Mayo Clinic Cancer Center: Vera Suman, Ph.D.; Stephanie Safgren; Matthew Ames, Ph.D.; Daniel Visscher, M.D.; Carol Reynolds, M.D.; Fergus Couch, Ph.D.; Wilma Lingle, Ph.D.; and James Ingle, M.D., in Rochester, Minn.; and Edith Perez, M.D., in Jacksonville, Fla.; David Flockhart, M.D., Ph.D., and Zeruesenay Desta, Ph.D., both from Indiana University are also co-authors.


'"/>

Source:University of Michigan Health System


Page: 1 2

Related biology news :

1. Gene variations explain drug dose required to control seizures
2. Survival of heart patients on beta-blockers varies greatly with genetic variation
3. Genetic variation alters response to common anti-clotting drug
4. Studies on human genome variation provide insight into disease
5. New discovery: Molecular variation in one gene affects the growth of natural populations
6. Researchers map of genetic variations implicated in disease
7. Gene variation increases SIDS risk in African Americans
8. Chimpanzee study reveals genome variation hotspots
9. A new kind of mutation could explain numerous phenotypic variations in various species
10. International team analyzes human genetic variation in key immune region
11. New technology used to construct the first map of structural variation in the human genome
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Gene variation affects tamoxifen benefit for breast cancer

(Date:8/24/2015)... MOUNTAIN VIEW, Calif. , Aug. 24, 2015  Based ... & Sullivan recognizes DERMALOG with the 2015 African Biometrics Company ... manufacturer and has achieved substantial commercial success in ... Nigeria , where it has implemented one of ... equipped 23 banks as well as the Central Bank of ...
(Date:8/20/2015)... 2015 NXT-ID, Inc. (NASDAQ: NXTD ) ... on the growing mobile commerce market and creator of ... Smart Card Alliance and the EMV Migration Forum.  ... Smart Card Alliance Latin America (SCALA) Chapter provides NXT-ID, ... thought leaders promoting adoption of smart card technology. ...
(Date:8/18/2015)... , Aug. 17, 2015 Research and ... of the "Global Biometric Authentication & Identification ... Estimation & Forecast, 2015-2020" report to their ... and identification systems market is expected to grow ... to 2020 and generate over $25 billion (approximately) ...
Breaking Biology News(10 mins):Frost & Sullivan Applauds DERMALOG's Rise as the Supplier of Best-in-class Biometric Solutions in Africa 2Frost & Sullivan Applauds DERMALOG's Rise as the Supplier of Best-in-class Biometric Solutions in Africa 3Frost & Sullivan Applauds DERMALOG's Rise as the Supplier of Best-in-class Biometric Solutions in Africa 4Frost & Sullivan Applauds DERMALOG's Rise as the Supplier of Best-in-class Biometric Solutions in Africa 5Frost & Sullivan Applauds DERMALOG's Rise as the Supplier of Best-in-class Biometric Solutions in Africa 6NXT-ID, Inc. Joins Smart Card Alliance and EMV Migration Forum 2NXT-ID, Inc. Joins Smart Card Alliance and EMV Migration Forum 3NXT-ID, Inc. Joins Smart Card Alliance and EMV Migration Forum 4Global Biometric Authentication & Identification Market 2015: Focus On Modality, Motility & Application - Estimation & Forecasts to 2020 for the $25 Billion Industry 2
... German . An international team of scientists led ... found the first fossil boreholes of the worm Osedax ... "boneworms" are at least 30 Million years old. This result was ... of the National Academy of Sciences of the USA (PNAS, ...
... learning book, "Touch the Earth," on Monday, April 19, in ... the National Mall organized by the Earth Day Network. This ... last month, with its authors and illustrators on hand to ... multimedia approach to teach middle school students about the Earth,s ...
... Ind. - A new biosensor developed at Purdue ... when communicating with each other, giving researchers a ... or seizure treatments. Marshall Porterfield, an associate ... engineering, postdoctoral researcher Eric McLamore, and graduate student ...
Cached Biology News:Bone-eating worms 30 million years old 2'Touch the Earth' to display at Earth Day on National Mall 2Sensor gives valuable data for neurological diseases and treatments 2Sensor gives valuable data for neurological diseases and treatments 3
(Date:8/27/2015)... ... August 27, 2015 , ... ... recently presented new data on the relationship of genetics and hypertension at the ... on Heart Disease in Vancouver, British Columbia, Canada. The event, which boasts an ...
(Date:8/26/2015)... 26, 2015  The Diabetes Research Institute (DRI), ... Miami Miller School of Medicine, announced today that ... test for the first time a novel transplant ... FDA approved Phase I/II study builds upon decades ... an important first step toward the development of ...
(Date:8/26/2015)... 26, 2015 After litigating and negotiating ... relating to P2i United States patent ... in the United States without any ... of either party. As a result of the parties, settlement, ... California dismissed the case without prejudice. ...
(Date:8/25/2015)... and CARDIFF, UK (PRWEB) , ... August 25, ... ... and accurately determining whether breast tissue lesions are cancerous is described by University ... SPIE, the international society for optics and photonics. , In “ Breast cancer ...
Breaking Biology Technology:Proove Biosciences Presents Ground-Breaking Data on Genetics and Heart Disease at 20th World Congress on Heart Disease 2Proove Biosciences Presents Ground-Breaking Data on Genetics and Heart Disease at 20th World Congress on Heart Disease 3Diabetes Research Institute Successfully Transplants First Patient In Pilot BioHub Trial 2Diabetes Research Institute Successfully Transplants First Patient In Pilot BioHub Trial 3Diabetes Research Institute Successfully Transplants First Patient In Pilot BioHub Trial 4P2i Settles United States Litigation 2New Optical Method Promises Faster, More Accurate Diagnosis of Breast Cancer 2New Optical Method Promises Faster, More Accurate Diagnosis of Breast Cancer 3New Optical Method Promises Faster, More Accurate Diagnosis of Breast Cancer 4
... 2 /PRNewswire-FirstCall/ - Oncolytics Biotech Inc. (TSX: ONC, NASDAQ: ... has been completed in the Phase II component of ... paclitaxel/carboplatin for patients with advanced cancers. The principal investigators ... Institute of Cancer Research, London, England, and Dr. Geoff ...
... statistical analysis technique that identifies and removes systematic ... could lead to more precise and reliable measurement ... industrial applications. Known as sequential profile adjustment ... the amount of experimental data required to make ...
... SHANGHAI, July 1 /PRNewswire-Asia/ -- WuXi PharmaTech ... had received an award from BASF for,excellent service and outstanding ... ingredients. , (Logo: http://www.newscom.com/cgi-bin/prnh/20040705/CNM002LOGO ... for a good CRO collaboration partner for years, and,today I ...
Cached Biology Technology:Oncolytics Biotech(R) Inc. Completes Patient Enrolment in U.K. Combination REOLYSIN(R) and Paclitaxel/Carboplatin Head and Neck Cancer Trial 2New statistical technique improves precision of nanotechnology data 2New statistical technique improves precision of nanotechnology data 3New statistical technique improves precision of nanotechnology data 4WuXi PharmaTech Receives Award from BASF 2
... to 48 lanes, 24 bi-directional, of patient ... from either slab gel or capillary sequencers, ... detection parameters in Explorer have been sealed ... We have built Explorer for ease of ...
Molecular Biological Resources offers bulk quantities of existing protein products. Please see the Chimerx divisions website for existing products and contact lloconne@molbiores.com for pricing....
... ISO 9001:2000 Certified USDA Research Registered OLAW ... Training AALAS Certified Technicians ... GLP Documentation Upon Request Focus ... for all your custom immunology service needs. ...
... data collection and automation that is controlled from ... Excel , Pre-configured library of interfaces for ... can be added and configured by the user ... into one spreadsheet , Allows for ...
Biology Products: