Navigation Links
Gene vaccine for Alzheimer's disease shows promising results

UT Southwestern Medical Center at Dallas researchers have found a way of stimulating the immune systems of mice to fight against amyloid proteins that cause the devastating plaques that are characteristic of Alzheimer's disease. For years scientists have examined the possibility of using a protein-based vaccine to slow the progression of the disease in its early stages. UT Southwestern researchers have created a gene-based vaccine aimed at stimulating the immune systems of mice to potentially fight off plaque-causing amyloid protein in the brain. Their findings appear in today's issue of the Archives of Neurology.

"Previous Alzheimer's vaccines were protein-based," said Dr. Baoxi Qu, the study's lead author and assistant professor in the Center for Biomedical Inventions and internal medicine. "We wanted to try a DNA-based genetic vaccine instead to see if we could enhance the immune response." Although prior studies of amyloid protein vaccination had shown some slowing in the plaque buildup, negative side effects also occurred in a handful of patients. Some had autoimmune responses that caused encephalitis. The key in the UT Southwestern study was finding another way to vaccinate patients without stimulating the body's own immune cytotoxic T cells, said Dr. Roger Rosenberg, a study author and director of the Alzheimer's Disease Center. "This dilemma was discussed with my colleagues, and we decided to try vaccination with an amyloid gene, rather than the amyloid protein vaccine," said Dr. Rosenberg. The UT Southwestern researchers vaccinated mice with a "gene gun." The gene gun and gene-vaccination technologies were invented by Dr. Stephen Albert Johnston, director of the Center for Biomedical Inventions and senior author of the latest study. "We have been developing ways to use gene-immunization to manipulate the immune response," Dr. Johnston said. "This study was the first step to see if we can apply these techni
'"/>

Source:UT Southwestern Medical Center at Dallas


Page: 1 2

Related biology news :

1. Research advances quest for HIV-1 vaccine
2. A much-needed shot in the arm for HIV vaccine development
3. Discovery of key proteins shape could lead to improved bacterial pneumonia vaccine
4. Influenza vaccine uses insect cells to speed development
5. Norovirus, AIDS vaccine and Hepatitis Virus
6. HIV vaccine trial breaks ground for future research
7. Live vaccines more effective against horse herpes virus
8. NIAID begins clinical trial of West Nile virus vaccine
9. Designing vaccines by computer
10. Wake Forest scientists find new combination vaccine effective against plague
11. New vaccine means bye-bye to bacteria in the lung
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Gene vaccine for Alzheimer disease shows promising results

(Date:7/31/2015)... de julio de 2015 La 10 th ... por medio de BGI del 22 al 25 de octubre de ... Este año, la conferencia celebra su décimo aniversario. Desde ... en una de las reuniones anuales más influyentes del mundo ... reuniones más dinámicas, entusiastas y mejores a nivel científico. ...
(Date:7/31/2015)... , Jul. 31, 2015 NXT-ID, Inc. (NASDAQ: ... company focused on the growing mobile commerce market and ... has filed provisional patent 62/198989 for ELECTRONIC ... highlights a method to advance crypto-currencies such as Bitcoin ... a common, uniform way to manage all payments.  ...
(Date:7/30/2015)... MOUNTAIN VIEW, Calif. , July 30, 2015 ... products and services for gene function analysis and ... CRISPR Guide RNA (sgRNA) Knockout Library targeting all ... to specifically and permanently "knock out" a gene,s ... library provides a high throughput screening tool so ...
Breaking Biology News(10 mins):La 10th International Conference on Genomics (ICG-10) se llevará a cabo en octubre 2La 10th International Conference on Genomics (ICG-10) se llevará a cabo en octubre 3NXT-ID Patents Electronic Crypto-Currency Management Technology 2NXT-ID Patents Electronic Crypto-Currency Management Technology 3NXT-ID Patents Electronic Crypto-Currency Management Technology 4CELLECTA, INC. Announces Launch of Human Whole Genome CRISPR Knockout Library 2
... for a good cause, there may be unintended consequences. ... the loss of wildlife habitat, particularly that of the ... ,from Michigan Technological University and The Nature Conservancy. ... of the journal BioScience , David Flaspohler, Joseph ...
... the sex chromosomes of several species of cichlid fish ... by which new sex chromosomes may evolve. In ... Science , biologists Thomas Kocher, Reade Roberts and ... genetic basis for two co-existing systems of sexual determination ...
... AMES, Iowa Plants and algae may be a ... ancient, finite hydrocarbons in fossil fuels, according to a ... Shanks. Shanks, Iowa State,s Manley R. Hoppe Professor ... hydrocarbons as a way to store carbon and energy. ...
Cached Biology News:In search of wildlife-friendly biofuels 2In search of wildlife-friendly biofuels 3East African cichlid fish offer new understanding of genetic basis of sex determination 2Iowa State researchers looking for catalyst that allows plants to produce hydrocarbons 2
(Date:8/26/2015)... ... August 26, 2015 , ... The 2015 Epigenomics & Metabolomics Meeting ... company Asymmetrex to share the first report on progress with its crowdsourcing ... counting adult tissue stem cells. , With a name like “H2A.Z asymmetry,” the new ...
(Date:8/25/2015)... ... August 25, 2015 , ... A ... are cancerous is described by University of Illinois researchers in the Journal ... photonics. , In “ Breast cancer diagnosis using spatial light interference microscopy ,” ...
(Date:8/25/2015)... , Aug. 25, 2015 Human Longevity, Inc. (HLI), ... Winham has joined the company as Chief Operating Officer. ... medical operations and technical experience, will report directly to HLI,s ... In this new role as COO, Winham will be responsible ... as well as all facility operations. HLI currently has three ...
(Date:8/25/2015)... ... August 25, 2015 , ... ... and rackmount computing infrastructure, today announced the launch of its next generation, ... latest system boasts two distinct, individually sledded workstation nodes in each 1U ...
Breaking Biology Technology:Asymmetrex Reports Positive Indicators for Crowdsourcing Campaign to Evaluate New Biomarker for Counting Adult Tissue Stem Cells for the First Time 2Asymmetrex Reports Positive Indicators for Crowdsourcing Campaign to Evaluate New Biomarker for Counting Adult Tissue Stem Cells for the First Time 3Asymmetrex Reports Positive Indicators for Crowdsourcing Campaign to Evaluate New Biomarker for Counting Adult Tissue Stem Cells for the First Time 4New Optical Method Promises Faster, More Accurate Diagnosis of Breast Cancer 2New Optical Method Promises Faster, More Accurate Diagnosis of Breast Cancer 3New Optical Method Promises Faster, More Accurate Diagnosis of Breast Cancer 4Human Longevity, Inc. Hires Life Sciences Leader, Mark Winham, as Chief Operating Officer 2Cirrascale® Announces Next Generation High Density, Two-in-One GPU Rackmount Offering Perfect for High Performance Remote Workstations 2Cirrascale® Announces Next Generation High Density, Two-in-One GPU Rackmount Offering Perfect for High Performance Remote Workstations 3
... on RDEA119 at the 2007, AACR-NCI-EORTC Conference ... SAN FRANCISCO, Oct. 24 Ardea Biosciences,Inc. (Nasdaq: ... discovery and development of,small-molecule therapeutics for the treatment ... preclinical data on its lead MEK,inhibitor, RDEA119, at ...
... 24 The Interstate,Alliance for Stem Cell Research should ... future sessions, the Foundation for Taxpayer and,Consumer Rights (FTCR) ... of various state,stem cell programs, is meeting today and ... Alliance is still in its early stages, it is ...
... Emisphere,Technologies, Inc. (Nasdaq: EMIS ) today announced ... of Vice President, Nonclinical Development and,Applied Biology, effective ... the oversight and management of nonclinical drug efficacy ... design of,discovery projects. Dr. Riley will report directly ...
Cached Biology Technology:New Oral MEK Inhibitor, RDEA119, Shows Favorable Anti-Tumor Properties 2New Oral MEK Inhibitor, RDEA119, Shows Favorable Anti-Tumor Properties 3New Oral MEK Inhibitor, RDEA119, Shows Favorable Anti-Tumor Properties 4Consumers Call On Interstate Stem Cell Group To Endorse Open Meetings 2Emisphere Technologies, Inc. Appoints Gary Riley as Vice President Nonclinical Development & Applied Biology 2Emisphere Technologies, Inc. Appoints Gary Riley as Vice President Nonclinical Development & Applied Biology 3Emisphere Technologies, Inc. Appoints Gary Riley as Vice President Nonclinical Development & Applied Biology 4
Opticon continuous fluorescence detector; includes optical base, analysis software, computer and monitor (this is an accessory for the DNA Engine thermal cyclers which must be ordered seperately)...
Hybridizer (220 V) For more information, please visit Dako' web-site. EU regulatory status: CE US regulatory status: IVD...
... in vascular proliferation, adhesion, and wound repair ... cell adhesion receptors consists of at least ... and b subunit that associate in a ... of the integrin family are based upon ...
... exchange media are rigid macroporous hydrophilic media. ... rates at moderate pressures, while the macroporous ... the hydrophilic matrix reduces nonspecific binding. Macro-Prep ... anion exchanger with very high flow rates ...
Biology Products: