Navigation Links
Gene therapy promising for growing tooth-supporting bone

A University of Michigan research team has found that introducing a growth factor protein into a mouth wound using gene therapy helped generate bone around dental implants, according to a new paper in the February issue of the journal Molecular Therapy.

In a patient with a sizeable mouth wound, replacing a tooth takes more than simply implanting a new one---the patient also needs the bone structure to anchor the new tooth in place. Such reconstructive surgery today involves either taking a bone graft from the patient's chin or jaw, which leaves a second wound needing to heal, or using donated bone from a tissue bank, which yields unpredictable results.

William Giannobile, professor of periodontics, prevention and geriatrics, led a team at the U-M School of Dentistry that delivered the gene encoding for bone morphogenetic protein-7 (BMP-7) to large bone defects in rats in an attempt to turn on the body's own bone growth mechanisms. The study showed that animals that got the BMP-7 treatment produced nearly 50 percent more supporting bone around dental implants than those receiving the conventional treatment.

"This study represents a proof-of-concept investigation. We are encouraged about the promise of this treatment," said Giannobile, also an associate professor of biomedical engineering and director of the Michigan Center for Oral Health Research.

More work will need to be done before the approach can be tested in humans, Giannobile added. He said he optimistically would like to see initial trials begin in humans in four to seven years.

BMP-7 is part of a family of proteins that regulates cartilage and bone formation. Recent studies have shown that BMPs are present in tooth development and periodontal repair.

This study mixed BMP-7 genes with an inactivated virus in a gel-like carrier and injected it into wounds. Giannobile said using a virus, with the harmful effects turned off, harnesses the virus' ability to enter in
'"/>

Source:University of Michigan


Page: 1 2 3

Related biology news :

1. Adding Radiation Therapy To Chemotherapy Improves Survival In Patients With High-risk Breast Cancer
2. Columbia research lifts major hurdle to gene therapy for cancer
3. Combination therapy boosts effectiveness of telomere-directed cancer cell death
4. Gene therapy converts dead bone graft to new, living tissue
5. Study identifies predictors of HIV drug resistance in patients beginning triple therapy
6. New imaging method gives early indication if brain cancer therapy is effective, U-M study shows
7. Muscle-targeted gene therapy reverses rare muscular dystrophy in mice
8. New therapy for HIV/AIDS eliminates needles and excessive toxicity
9. New Treatment Rivals Chemotherapy For Lymphoma, Study Finds
10. Gene therapy for Parkinsons disease moves forward in animals
11. Pulsating ultrasound enhances gene therapy for tumors
Post Your Comments:
(Date:7/25/2008)...e discoveries into the clinical arena is widely ac...cal College of Wisconsin, in Milwaukee, and Nation...why clinical science grant applications receive le...applications to the NIH. The findings were publish...edicine . , In collaboration with Michael R. Mar...
(Date:7/24/2008)...or bio-fuels and hydro-electricity due to high fos...day to the preservation of precious wetlands world...for agriculture, energy crop plantations and hydro... wetlands is vital to avoid destroying ecosystems ...nity, including safe, steady local water supplies,...
(Date:7/24/2008)...ovirus (CMV), which most commonly affects people w...spital intensive-care patients who have no immune-...ers have found. CMV infection is also associated w...stays independent of other causes, according to th... of the American Medical Association . , About ...
(Date:7/24/2008)...iversity and the University of Texas at Austin hav...by genes, efforts to prevent or tolerate errors in... that the cost of errors in protein production may...than the loss of functional proteins. Misfolded pr...ons, and cause neurodegenerative diseases. , The...
Breaking Biology News(10 mins):New study spotlights National Institutes of Health grant outcomes for clinical research 2Rising energy, food prices major threats to wetlands as farmers eye new areas for crops 2Rising energy, food prices major threats to wetlands as farmers eye new areas for crops 3CMV infections affect more than just patients with compromised immune systems, researchers find 2Various species' genes evolve to minimize protein production errors 2Various species' genes evolve to minimize protein production errors 3SouthWest Benefits Association Elects New Board of Directors 21956 1SouthWest Benefits Association Elects New Board of Directors 21956 2HIPAA Privacy Rule Impedes Biomedical Research 6014 1HIPAA Privacy Rule Impedes Biomedical Research 6014 2Breakthroughs Ahead Endocrine Society Tells Security Analysts 6012 1Breakthroughs Ahead Endocrine Society Tells Security Analysts 6012 2New study shows American Cancer Society program helps employers 21954 1New study shows American Cancer Society program helps employers 21954 2New study shows American Cancer Society program helps employers 21954 3
...understanding of how animals learn--and learn from...ts that use frog acoustic cues to find quality pre...bats. While numerous examples are known of instanc...ing" to learn new visual and olfactory cues associ...ic cue had not been previously described. The work...
...ells and causes disease, researchers are usually q...ientists are learning that some neurodegenerative ...ly normal. The diseases can be caused when the gen...ecuted properly, leading to a lethal buildup of ma...es by Howard Hughes Medical Institute (HHMI) inves...
... mussels are hard to beat. They can adhere to virt...ng their tenacious bonds in saltwater, including t...ver, about exactly how the bivalves achieve this a...the week of Aug. 14 by the Proceedings of the Nati...y research team sheds new light on the adhesive st...
...ains live or die depends on whether they can muscl...ns. Neuroscientists at the Salk Institute for Biol...gear required for a young neuron to successfully j..., In a study published in a forthcoming issue of N...D., a professor in the Gene Expression Laboratory ...
Other Biology News:Cultural transmission in bats: When listening for dinner, bats learn from their neighbors 2'Sticky' mice lead to discovery of new cause of neurodegenerative disease 2'Sticky' mice lead to discovery of new cause of neurodegenerative disease 3'Sticky' mice lead to discovery of new cause of neurodegenerative disease 4Study reveals details of mussels' tenacious bonds 2Life and death in the hippocampus: what young neurons need to survive 2Life and death in the hippocampus: what young neurons need to survive 3
(Date:7/25/2008)...e-FirstCall/ -- China Medical,Technologies, Inc. (...ased,medical device company that develops, manufac...ducts and high intensity focused ultrasound tumor,...version rate for the,Company,s US$150 million outs... due November 2011 (the ,Convertible Notes,)., ...
(Date:7/24/2008)...wswire-FirstCall/ -- Coherent, Inc.,(Nasdaq: COH...financial,results after the market close and host ... 2008 results scheduled for July 30, 2008 at 4:30 ...e Internet and can be accessed,at either http://w...s.com .,For those who are not available to listen ...
(Date:7/24/2008)...ire-FirstCall/ -- InterMune, Inc.,(Nasdaq: ITMN )...er 2008,financial results and provide a business u...ern time. A live conference call and webcast will ...hat same day., To access the live teleconference,...tional), conference ID# 57393097. To access the,we...
(Date:7/24/2008)...an to Help Spearhead Growth, PITTSBURGH, July 24 ...http://www.hmsinc.com ), pioneering health informa...l has been appointed vice president, sales., Dock...les, sales,management and product distribution for...and pharmaceutical companies., "Karen has an impr...
Breaking Biology Technology:China Medical Technologies Adjusts Conversion Rate of Convertible Notes 2InterMune to Release Second Quarter 2008 Financial Results and Provide Business Update on July 31 2Health Monitoring Systems Appoints Karen S. Dockrell As VP, Sales 2
...s has always been to build a business from scratch...is same dream in the 1990s but we wanted to speed ...uld happen in a year or two. , ,In a few rare cas... businesses. The battle cry from entrepreneurs the...: Patience is a virtue shared by fools and jackass...
...d.com , , WTN: What,s the next big thing in techn..., it will be the continuous improvements in CRM to...and e-commerce companies lies in better connecting...f us in the business and technology communities mu...ers. Doing so will result in deeper relationships...
...n the World Health Organization has laid down an u... AIDS and develop an antidote to nicotine addictio...ive place. , ,Tom Loftus, the former U.S. ambassad...in Assembly, added a sobering global perspective t...ference in Madison. The special adviser to WHOs Di...
... to thrive in an increasingly competitive atmosphe...consin Public Radio reports on one rather unusual ...-dating introduced in by The Wisconsin Technology ...yer , ,Its not the big that eat the small; its th...kick off a business seminar on speed networking, a...
Other Biology Technology:An Overnight Business Success Takes 20 Years 2An Overnight Business Success Takes 20 Years 3The Next Big Thing in E-Commerce - Guild.com CEO comments on Wisconsin's technology vision 2AIDS and tobacco are worldwide killers: Is bioscience doing enough to stop them? 2Looking to be Competitive? Try Speed Networking 2
Mouse Anti-Gemin2
RayBio Human Angiogenesis Antibody Array 2.1 (8 array membranes) with Accessory, detects 23 angiogenic factors (for lysate) Class: Antibody Array Products Product Group: Antibody Array
See product name for description.
Cryo/CryoPlus Inventory Racks for cryogenic vials. Racks are available with cardboard or stainless steel boxes for 2ml, 4ml, or 5ml cryo vials. Vapor phase or Liquid phase racks available. Platfor
Biology Products: