Navigation Links
Gene therapy inhibits epilepsy in animals

For the first time, researchers have inhibited the development of epilepsy after a brain insult in animals. By using gene therapy to modify signaling pathways in the brain, neurology researchers found that they could significantly reduce the development of epileptic seizures in rats.

"We have shown that there is a window to intervene after a brain insult to reduce the risk that epilepsy will develop," said one of the lead researchers, Amy R. Brooks-Kayal, M.D., a pediatric neurologist at The Children's Hospital of Philadelphia and associate professor of Neurology and Pediatrics at the University of Pennsylvania School of Medicine. "This provides a 'proof of concept' that altering specific signaling pathways in nerve cells after a brain insult or injury could provide a scientific basis for treating patients to prevent epilepsy."

Dr. Brooks-Kayal and Shelley J. Russek, Ph.D., of Boston University School of Medicine were senior authors of the study in the Nov. 1 Journal of Neuroscience.

Working in a portion of the brain called the dentate gyrus, the researchers focused on one type of cell receptor, type A receptors, for the neurotransmitter gamma-aminobutyric acid (GABA). When GABA(A) receptors are activated, they inhibit the repetitive, excessive firing of brain cells that characterizes a seizure. Seizures are thought to occur, at least in part, because of an imbalance between two types of neurotransmitters: the glutamate system, which stimulates neurons to fire, and the GABA system, which inhibits that brain activity.

GABA's inhibitory role is considered particularly important in the dentate gyrus because the dentate gyrus acts as a gateway for brain activity into the hippocampus, an area that is critical to generating seizures in temporal lobe epilepsy, the most common type of epilepsy in children and adults.

GABA(A) receptors are made up of five subunits--proteins that play important roles in brain development and in cont
'"/>

Source:Children's Hospital of Philadelphia


Page: 1 2

Related biology news :

1. Adding Radiation Therapy To Chemotherapy Improves Survival In Patients With High-risk Breast Cancer
2. Columbia research lifts major hurdle to gene therapy for cancer
3. Combination therapy boosts effectiveness of telomere-directed cancer cell death
4. Gene therapy converts dead bone graft to new, living tissue
5. Study identifies predictors of HIV drug resistance in patients beginning triple therapy
6. New imaging method gives early indication if brain cancer therapy is effective, U-M study shows
7. Muscle-targeted gene therapy reverses rare muscular dystrophy in mice
8. New therapy for HIV/AIDS eliminates needles and excessive toxicity
9. New Treatment Rivals Chemotherapy For Lymphoma, Study Finds
10. Gene therapy for Parkinsons disease moves forward in animals
11. Pulsating ultrasound enhances gene therapy for tumors
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Gene therapy inhibits epilepsy animals

(Date:10/15/2014)... PORT WASHINGTON, N.Y. , Oct. 15, 2014 ... in technology solutions for home and community-based care, ... the benefits of implementing Sandata,s Santrax® Electronic Visit ... Quality Care Services is a home health company ... Texas . ...
(Date:10/15/2014)... Ebola virus is spreading rapidly and to an unexpected ... in the past and the virus shows a new ... recorded before. For this reason, the German National Academy ... Science and Engineering, and the Union of the German ... on the Ebola epidemic today. , In the statement ...
(Date:10/15/2014)... VILNIUS, Lithuania , Oct. 15, 2014 /PRNewswire/ ... identification technologies, today announced the availability of the ... . VeriLook Surveillance 3.0 provides real-time biometric face ... multiple high-resolution digital surveillance cameras. The new version ... detects and differentiates people from objects while they ...
Breaking Biology News(10 mins):Sandata Announces Case Study with Quality Care Services, Inc. 2Academies call for consequences from the Ebola virus epidemic 2Academies call for consequences from the Ebola virus epidemic 3Academies call for consequences from the Ebola virus epidemic 4Academies call for consequences from the Ebola virus epidemic 5VeriLook Surveillance 3.0 SDK Identifies Faces and Moving Objects, Differentiates Pedestrians from Other Moving Objects in Video Surveillance Systems 2VeriLook Surveillance 3.0 SDK Identifies Faces and Moving Objects, Differentiates Pedestrians from Other Moving Objects in Video Surveillance Systems 3
... CORVALLIS, Ore. As oceans warm due to climate change, ... plankton that pump carbon out of the atmosphere but ... increase global warming or decrease it. The forces at ... University scientists in an article to be published Friday in ...
... evolutionary history of Antarctic fish and their "anti-freeze" proteins illustrates ... fish adapted to newly formed polar conditions and how ... temperatures. , "A rise of 2 degrees centigrade of water ... fish lineage, which is so well adapted to water at ...
... researchers are taking an historical approach to predict ... Robert van Woesik, professor of biological sciences, the ... into how these corals today may fare through ... past regional extinction events and modern coral vulnerability, ...
Cached Biology News:Ocean microbe communities changing, but long-term environmental impact is unclear 2Ocean microbe communities changing, but long-term environmental impact is unclear 3Fish of Antarctica threatened by climate change 2Coral survival's past is key to its future 2
(Date:10/19/2014)... The Asian Automatic patient billing report defines ... forecast of revenue. The Automatic patient billing market in ... by 2018, at a developing CAGR of 7.2% from ... the Asian Automatic patient billing market, to get an ... a glimpse of the segmentation of this market in ...
(Date:10/19/2014)... (PRWEB) October 19, 2014 The report ... Market Share, Trade, Prices, Geography Trend and Forecast (2011 ... sales category, and geography and studies the major market ... North America, Europe, and Asia. , The global chocolate ... 2010.to $98.3 billion in 2016 at an estimated CAGR ...
(Date:10/19/2014)... October 19, 2014 The report ... & Homeland Security), Technology, Payload, Type & by ... segments the global unmanned ground vehicle market into ... forecasting of market sizes. The report also identifies ... opportunities impacting it along with the adoption trends. ...
(Date:10/18/2014)... The “Human Insulin Market- by Product Type, [Human ... Insulin (Rapid Acting, Long Acting, Premixed)], by Brand ... Forecast to 2018” provides a detailed overview of ... trends, and strategies impacting the global human insulin ... the revenue and share analysis. , The global ...
Breaking Biology Technology:The Asian Automatic patient billing market is estimated to grow to around $463.9 million by 2018 - New Report by MicroMarket Monitor 2The Asian Automatic patient billing market is estimated to grow to around $463.9 million by 2018 - New Report by MicroMarket Monitor 3Chocolate Market Projected To Reach $98.3 Billion by 2016 - New Report by MarketsandMarkets 2Chocolate Market Projected To Reach $98.3 Billion by 2016 - New Report by MarketsandMarkets 3Chocolate Market Projected To Reach $98.3 Billion by 2016 - New Report by MarketsandMarkets 4Unmanned Ground Vehicle (UGV) Market Estimated to Reach $8.26 Billion by 2020 - New Research Report by MarketsandMarkets 2Unmanned Ground Vehicle (UGV) Market Estimated to Reach $8.26 Billion by 2020 - New Research Report by MarketsandMarkets 3Unmanned Ground Vehicle (UGV) Market Estimated to Reach $8.26 Billion by 2020 - New Research Report by MarketsandMarkets 4Unmanned Ground Vehicle (UGV) Market Estimated to Reach $8.26 Billion by 2020 - New Research Report by MarketsandMarkets 5Medical Human Insulin Market Is Expected to Reach $42 billion by 2019 - New Research Report by MarketsandMarkets 2Medical Human Insulin Market Is Expected to Reach $42 billion by 2019 - New Research Report by MarketsandMarkets 3Medical Human Insulin Market Is Expected to Reach $42 billion by 2019 - New Research Report by MarketsandMarkets 4Medical Human Insulin Market Is Expected to Reach $42 billion by 2019 - New Research Report by MarketsandMarkets 5
... Available In ... Texas, ... of the Trinity Mother Frances Neuroscience,Institute is the first in the region ... patients a chance to maintain,motion in their necks following surgery for cervical ...
... DuPont Ranks Ahead of Other Companies in Plant Biotechnology ... DD ),has been named one of the best ... Science Magazine Top Employers survey. This is the ... The,company,s number seven ranking places it ahead of other ...
... leader in radiation,oncology and non-invasive neurosurgery solutions, will ... Meeting of The American Society for,Therapeutic Radiology and ... efficiency. The meeting will be held October,28 - ... (Los Angeles,California, USA). Elekta will showcase innovative offerings ...
Cached Biology Technology:Video: Trinity Mother Frances Neurosurgeon Using New Disc System for Patients With Degenerative Diseases of the Neck 2DuPont Named Among Top Biotechnology Employers by Science Magazine 2Elekta Announces New Cancer Care Solutions and Highlights Personalized Efficiency at ASTRO 2007 2Elekta Announces New Cancer Care Solutions and Highlights Personalized Efficiency at ASTRO 2007 3Elekta Announces New Cancer Care Solutions and Highlights Personalized Efficiency at ASTRO 2007 4
...
... bioinformatics software that has changed the way ... design of BioNumerics allows for integration and ... data employed for the characterization of organisms ... protein gels, HPLC, VNTR, MLST, SNP, fatty ...
Request Info...
Cultrex 3D Culture Matrix Rat Collagen I....
Biology Products: