Navigation Links
Gene therapy converts dead bone graft to new, living tissue

Researchers have created a way to transform the dead bone of a transplanted skeletal graft into living tissue in an experiment involving mice. The advance, which uses gene therapy to stimulate the body into treating the foreign splint as living bone, is a promising development for the thousands of cancer and trauma patients each year who suffer with fragile and failing bone grafts. The findings were posted online Feb. 13 and will appear in the March 1 issue of Nature Medicine.

The procedure, designed by a team led by Edward M. Schwarz, Ph.D., associate professor of orthopedics and of microbiology and immunology at the University of Rochester Medical Center, is intended to eventually aid people with various cancers or injuries whose treatment involves the replacement of large sections of bone. Cancers such as osteosarcoma, one of the most common types of bone cancers, or tumors that occur adjacent to bones, often must be treated by removing the diseased section of bone and replacing it with the only alternative available ?a donated section of comparable bone from a cadaver. The new splint of bone is then literally screwed into place, giving the patient most of the strength and support of the original bone. Bone, unlike any other tissue in the human body, can still perform one of its functions, structural support, even if all its cells are completely dead. A serious problem arises, however, when the bone wears over time.

"Everyday activities cause microscopic fractures in our bones," explains Schwarz. "Those fractures are normal and healthy, and our bones re-knit them constantly. But when the bone is dead, there is no healing, and those tiny fractures begin to accumulate until finally, perhaps in 10 years, the implanted section collapses, and more drastic surgery becomes necessary."

To make the transplanted bone more robust, Schwarz looked into the activity of the genes and proteins that govern its health. His team replaced sections of bones in
'"/>

Source:University of Rochester Medical Center


Page: 1 2 3 4

Related biology news :

1. Adding Radiation Therapy To Chemotherapy Improves Survival In Patients With High-risk Breast Cancer
2. Columbia research lifts major hurdle to gene therapy for cancer
3. Combination therapy boosts effectiveness of telomere-directed cancer cell death
4. Study identifies predictors of HIV drug resistance in patients beginning triple therapy
5. New imaging method gives early indication if brain cancer therapy is effective, U-M study shows
6. Muscle-targeted gene therapy reverses rare muscular dystrophy in mice
7. New therapy for HIV/AIDS eliminates needles and excessive toxicity
8. New Treatment Rivals Chemotherapy For Lymphoma, Study Finds
9. Gene therapy for Parkinsons disease moves forward in animals
10. Pulsating ultrasound enhances gene therapy for tumors
11. Antiretroviral therapy may prevent excess risk of some cancers in people with HIV
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Gene therapy converts dead bone graft new living tissue

(Date:12/5/2014)... MOUNTAIN VIEW, Calif. , Dec. 4, 2014 ... and safety has boosted investments in new testing ... products has also given rise to a range ... driven by the requirements of Generation Y, which ... digital technologies. As a result, product development strategies ...
(Date:12/3/2014)... -- As part of our commitment to offering the ... announce the release of a new reader that will ... data that they need. The Atlas 2000 ... readers. Many such devices have serious shortcomings when it ... models force users to navigate numerous complicated steps in ...
(Date:11/21/2014)... Wash. , Nov. 20, 2014 C-Labs ... for the Internet of Things (IoT), today announced the ... of chief operating officer. Previously a strategic advisor to ... finance, and operations. Mr. Traynor is based out of ... . He reports to Chris Muench , Chief ...
Breaking Biology News(10 mins):Emerging Technologies Enable Smarter Monitoring of Assets, Push Industrial Testing, Inspection and Monitoring Market 2Emerging Technologies Enable Smarter Monitoring of Assets, Push Industrial Testing, Inspection and Monitoring Market 3Emerging Technologies Enable Smarter Monitoring of Assets, Push Industrial Testing, Inspection and Monitoring Market 4Inception Technologies to Release New Biometric Reader 2C-Labs Names Former Microsoft and Bsquare Executive as Chief Operating Officer 2
... play a bigger role than food alone, when it comes ... evidence over the past 150 years found that the effects ... override the effects of food alone on tooth decay. The ... Obesity Reviews . Professor Monty Duggal, an author ...
... Space Biomedical Research Institute (NSBRI) has selected Daniela ... one of four young investigators in the nation ... is a postdoctoral fellow in Georgetown,s Lombardi Comprehensive ... and Molecular & Cellular Biology. In the ...
... Sawyer will use a $120,000 grant from the Foundation for ... the cells it attacks have evolved together over time. The ... drugs. When HIV infiltrates cells, the virus hijacks its ... It has been recently found that the retrovirus hijacks about ...
Cached Biology News:GUMC young scientist selected postdoc Fellow at National Space Biomedical Research Institute 2Evolutionary biologist will study HIV with grant from AIDS research foundation 2
(Date:12/24/2014)... December 23, 2014 Pipette.com announces their ... Twitter followers can submit their #HolidayInTheLab pictures for a ... lab mates. , For those struggling to think of ... Pipette.com Holiday in the Lab Contest provides the ideal ... followers to send pictures of their chemistree, holiday ...
(Date:12/24/2014)... , December 23, 2014 ... Algeria , out today and available for free download ... actors driving change and growth in the sector today. ... scored notable successes has been in developing a homegrown pharmaceutical ... percent local production still remains some way off. A cursory ...
(Date:12/24/2014)... NEW YORK , Dec. 23, 2014 ... pilot study of mazindol in children with attention deficit/hyperactivity ... in December 2014 . The paper, ... with attention deficit/hyperactivity disorder" ( Konofal et al, ... 1;8:2321-2332. eCollection 2014 ) shows that mazindol might ...
(Date:12/22/2014)... , Dec. 22, 2014 /PRNewswire/ - RepliCel Life Sciences ... medicine company focused on the development of autologous cell ... of the University of Calgary in conjunction with co-authors ... which further validates the company,s ongoing clinical research using ... of pattern baldness. The paper entitled " ...
Breaking Biology Technology:Major Pipette Distributor Pipette.com Announces their Holiday in the Lab Contest 2PharmaBoardroom Releases New Algeria Pharmaceuticals Report 2PharmaBoardroom Releases New Algeria Pharmaceuticals Report 3Redefining ADHD: A New Approach & A Shift of Paradigm in ADHD Therapeutics 2Redefining ADHD: A New Approach & A Shift of Paradigm in ADHD Therapeutics 3Newly Released Peer-Reviewed Publication Further Validates RepliCel's Use of Dermal Sheath Cup Cells to Treat Pattern Baldness 2Newly Released Peer-Reviewed Publication Further Validates RepliCel's Use of Dermal Sheath Cup Cells to Treat Pattern Baldness 3Newly Released Peer-Reviewed Publication Further Validates RepliCel's Use of Dermal Sheath Cup Cells to Treat Pattern Baldness 4Newly Released Peer-Reviewed Publication Further Validates RepliCel's Use of Dermal Sheath Cup Cells to Treat Pattern Baldness 5
... LEXINGTON, Mass., June 24 Instrumentation Laboratory,(IL) today ... Premier 4000,critical care analyzer. The recipient for this ... IL began shipping the new GEM Premier 4000,analyzers ... The remarkable,commercial success of this breakthrough analyzer underlines ...
... IRVINE, Calif., June 24 Stason Pharmaceuticals, ... announced,today that it has appointed Diana Wood ... be responsible for all business development,functions, including ... is a senior executive with extensive experience ...
... British Columbia researchers has developed a technique that controls ... superconductors, a procedure considered impossible for the past two ... the team deposited potassium atoms onto the surface of ... the scientists to continuously manipulate the number of electrons ...
Cached Biology Technology:Instrumentation Laboratory Ships 1000th GEM Premier 4000 Analyzer to Scripps Health 2Instrumentation Laboratory Ships 1000th GEM Premier 4000 Analyzer to Scripps Health 3Stason Pharmaceuticals, Inc. Appoints Diana Wood as Vice President, Business Development 2UBC physicists develop 'impossible' technique to study and develop superconductors 2
... useful for routine procedures. Hollandes contains formaldehyde ... will decalcify small bone specimens. Tissue that ... successfully with most stains, and the cupric ... cell membranes and cosinophil and endocrine cell ...
... CHEMICON's In Vitro Osteogenesis Assay Kit ... MC3T3-E1cells to a mature osteoblastic lineage, as ... this kit provides all the necessary reagents ... a standard plate reader. This product is ...
... gold standard for automated bioresearch: Developed ... applications • Based on decades of ... accessories designed for bioresearch • Holographic ... Versatility, reliability and ease-of-use • Pulsed ...
... Using information-rich MSn data, the patent-pending ... multiple levels of fragmentation, isotope pattern ... to accurately determine the correct formula ... approaches for deducing empirical formulae from ...
Biology Products: