Navigation Links
Gene that makes people 'early to bed and early to rise' demystified

latively rare, inherited condition in which people are "morning larks," with early morning awakening and early sleep times. People with the condition generally show changes in core body temperatures and other characteristics governed by the circadian clock that are shifted up by three to four hours. The syndrome is passed on in a dominant fashion, meaning that it takes just one copy of the abnormal gene to exhibit symptoms.

The UCSF group had earlier discovered a variant of the human Per2 gene that causes FASPS. They also showed that the so-called "S662G" variant, in which the serine building block normally present at position 662 is replaced by glycine, prevented a regulatory enzyme from tacking a phosphate onto the encoded protein.

Now, the researchers report additional evidence that the lost "phosphorylation" prevents a cascade of chemical modifications that are normally primed by the initial event.

Moreover, they show that the human gene inserted into otherwise normal mice causes them to rise early, symptoms that mirror those in people with FASPS. In contrast, a mutation that mimicked an increase in phosphorylation at amino acid 662 increased the transcription of PER2 and pushed the animals' sleep pattern later.

Their studies in mice revealed that the amino acid change associated with FASPS, which alters the charge of the residue, alters the ability of PER2 to regulate its own transcription. PER2 presumably manages such regulation through interaction with other proteins since it doesn't bind DNA itself, they said.

The findings led the researchers to suggest a model of clock function in which cells sense changing PER2 levels over time, beginning a new daily cycle when a certain threshold is crossed.

"In S662G individuals or mice, the alteration in transcription leads to production of less PER2, while the clock protein's degradation remains unaffected," they explained. Thus, the researchers added, "PER2 leve
'"/>

Source:Cell Press


Page: 1 2 3

Related biology news :

1. University of Manchester makes made-to-measure skin and bones a reality using inkjet printers
2. Grass makes environmentally friendly biofuel
3. Shampoo detergent added to paint makes surfaces self-sterilizing
4. Biota makes major antiviral discovery
5. Green diesel: New process makes liquid transportation fuel from plants
6. Discovery that bacterium is phosphate gourmet key clue to what makes it most social of bacteria
7. Technique makes it easier to see mouse embryo in all its glory
8. In the minds eye: How the brain makes a whole out of parts
9. African parasite makes component of fat differently from all other organisms
10. Coffee makes us more likely to say yes
11. Eat less, weigh more? Enzyme makes lean mice susceptible to dietary fat
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Gene that makes people early bed and early rise demystified

(Date:9/29/2014)... In popular culture, mathematics is often deemed inaccessible or ... ever more important role in our daily lives and ... new ideas often behind the scenes. , UC ... of Mathematics and an assistant professor of mechanical engineering, ... Some of his recent research published in the ...
(Date:9/29/2014)... real-time feedback system together with a human energy delegate ... of 37% in energy consumption when compared to normal ... to a reduction of 713.71 kg of CO 2 ... eight halls, exposed only to the real-time feedback and ... reduction in energy consumption. , Student,s energy-use behaviour is ...
(Date:9/29/2014)... spheres of fluid, not normally considered capable of doing ... droplets of alcohol move through water. In the future, ... to move on your own to be self-moving ... But also non-living entities can be self-moving, report researchers ... Technology in Prague, Czech Republic. , The researchers have ...
Breaking Biology News(10 mins):At the interface of math and science 2At the interface of math and science 3At the interface of math and science 4Scientists make droplets move on their own 2
... how a human cell is supposed to work, it,s hard ... -- as it does in cancer. That,s why a Florida ... $1.2 million grant to explore the role of centrosomes and ... human disease. Tim Megraw, a veteran researcher who joined ...
... BIRMINGHAM, Ala. University of Alabama at Birmingham (UAB) ... Alabama,s Dauphin Island coastline are working to keep the ... Diamondback Terrapin has been a national delicacy, a source ... and victim of new predators, but now its prospects ...
... 22, 2009) -- The tools of biochemistry have finally ... University in Houston and the University of Florence in ... which was the first known genetic regulatory protein when ... tied together two segments within individual molecules of lactose ...
Cached Biology News:Researcher awarded $1.2 million grant to study centrosomes and cilia 2UAB research team saves turtle species on the brink 2UAB research team saves turtle species on the brink 3All tied up: Tethered protein provides long-sought answer 2All tied up: Tethered protein provides long-sought answer 3
(Date:9/30/2014)... 2014 UFP Technologies, a producer ... has recently introduced a custom insulated shipping container ... The new insulated shipper solves the issue of ... UFP Technologies’ BioShell is a universal storage container ... handling and shipping. The insulated shipper keeps frozen ...
(Date:9/29/2014)... September 30, 2014 Each year ... injuries require medical attention. In the military, burn ... complications to battlefield medical care. More than 800 ... Afghanistan. Burn wounds heal slowly, remain inflamed and ... excessive, physically debilitating and functionally damaging. While developments ...
(Date:9/29/2014)... -- Research and Markets  has announced the addition ... Services, End-User , Application - Global Forecast to 2019" ... global oligonucleotide synthesis market is expected to reach $1,712.1 ... at a CAGR of 9.8% from 2014 to 2019. ... basis of products and services, applications, end users, and ...
(Date:9/29/2014)... Research and Markets  has announced the addition of ... Chromatograph Market by Type , Technology, Spectroscopy, Gas chromatography, ... to 2013 - 2020" report to their offering. ... analytical instrument that provides chemical composition data on process ... which companies carry out their production and improve the ...
Breaking Biology Technology:UFP Technologies Introduces Insulated Shipping Container For Bulk Drug Transportation 2UFP Technologies Introduces Insulated Shipping Container For Bulk Drug Transportation 3Faster Healing with Fewer Scars 2Oligonucleotide Synthesis (Diagnostics, PCR, QPCR, Gene Synthesis, NGS, DNA, RNAi) Market - Global Forecast to 2019 2Oligonucleotide Synthesis (Diagnostics, PCR, QPCR, Gene Synthesis, NGS, DNA, RNAi) Market - Global Forecast to 2019 3Global Process Liquid Analyzer, Gas Analyzer, and Gas Chromatograph (PH/ORP, Chlorine, Oxygen, Carbon dioxide) Market - Trends & Forecast to 2020 2Global Process Liquid Analyzer, Gas Analyzer, and Gas Chromatograph (PH/ORP, Chlorine, Oxygen, Carbon dioxide) Market - Trends & Forecast to 2020 3Global Process Liquid Analyzer, Gas Analyzer, and Gas Chromatograph (PH/ORP, Chlorine, Oxygen, Carbon dioxide) Market - Trends & Forecast to 2020 4
... AIS is a provider of browser-based policy, ... the system allows business users to maintain much ... technical resources are conserved. The combination of Fiserv ... companies to automate customer communication, provide high levels ...
... ,You did it; you brought Bill Gates to his tender knees. ... campus. 'Curses, you worm writer, you!" It echoed among the buildings, ... teeth. And beneath the whimpers you could almost hear Billy saying ... money and fix my software."* , ,Wow, if only ...
... get techies into ballgame, too , ,As the ... recent or soon-to-be college grads may view a career ... could only see what really goes on in todays ... systems, robotic welding, remote sensoring and other modern staples ...
Cached Biology Technology:Open Letter: Blasted Worm 2Open Letter: Blasted Worm 3Manufacturing still viable career 2Manufacturing still viable career 3
sterile filtered, off the clot, all male donors, Total Protein: 4.5 to 8.5 g/dl...
sterile filtered, off the clot, all male donors, Total Protein: 4.5 to 8.5 g/dl...
... Designed to histochemically detect ... distinct pH in cultured ... The specific marker is ... cells (not found in ...
TAR DNA binding protein...
Biology Products: