Navigation Links
Gene that makes people 'early to bed and early to rise' demystified

latively rare, inherited condition in which people are "morning larks," with early morning awakening and early sleep times. People with the condition generally show changes in core body temperatures and other characteristics governed by the circadian clock that are shifted up by three to four hours. The syndrome is passed on in a dominant fashion, meaning that it takes just one copy of the abnormal gene to exhibit symptoms.

The UCSF group had earlier discovered a variant of the human Per2 gene that causes FASPS. They also showed that the so-called "S662G" variant, in which the serine building block normally present at position 662 is replaced by glycine, prevented a regulatory enzyme from tacking a phosphate onto the encoded protein.

Now, the researchers report additional evidence that the lost "phosphorylation" prevents a cascade of chemical modifications that are normally primed by the initial event.

Moreover, they show that the human gene inserted into otherwise normal mice causes them to rise early, symptoms that mirror those in people with FASPS. In contrast, a mutation that mimicked an increase in phosphorylation at amino acid 662 increased the transcription of PER2 and pushed the animals' sleep pattern later.

Their studies in mice revealed that the amino acid change associated with FASPS, which alters the charge of the residue, alters the ability of PER2 to regulate its own transcription. PER2 presumably manages such regulation through interaction with other proteins since it doesn't bind DNA itself, they said.

The findings led the researchers to suggest a model of clock function in which cells sense changing PER2 levels over time, beginning a new daily cycle when a certain threshold is crossed.

"In S662G individuals or mice, the alteration in transcription leads to production of less PER2, while the clock protein's degradation remains unaffected," they explained. Thus, the researchers added, "PER2 leve
'"/>

Source:Cell Press


Page: 1 2 3

Related biology news :

1. University of Manchester makes made-to-measure skin and bones a reality using inkjet printers
2. Grass makes environmentally friendly biofuel
3. Shampoo detergent added to paint makes surfaces self-sterilizing
4. Biota makes major antiviral discovery
5. Green diesel: New process makes liquid transportation fuel from plants
6. Discovery that bacterium is phosphate gourmet key clue to what makes it most social of bacteria
7. Technique makes it easier to see mouse embryo in all its glory
8. In the minds eye: How the brain makes a whole out of parts
9. African parasite makes component of fat differently from all other organisms
10. Coffee makes us more likely to say yes
11. Eat less, weigh more? Enzyme makes lean mice susceptible to dietary fat
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Gene that makes people early bed and early rise demystified

(Date:12/22/2014)... 2014 Research and Markets ... of the "The Global Watermarking and ... http://photos.prnewswire.com/prnh/20130307/600769 ... of the global digital media watermarking and ... monitor piracy by securely and invisibly embedding ...
(Date:12/19/2014)... 2014   LaunchKey , the first decentralized mobile ... Internet of Things era, today announced the close of ... was led by Metamorphic Ventures with participation from ENIAC ... and others.  LaunchKey has raised $4 million to date, ... team and bring LaunchKey to market in 2015. ...
(Date:12/17/2014)... DUBLIN , Dec. 16, 2014 Research ... announced the addition of the "Global Chemical ... http://photos.prnewswire.com/prnh/20130307/600769 ... is the increasing demand for medical sensors in ... patient data for quick and correct diagnosis during ...
Breaking Biology News(10 mins):The Global Watermarking and Fingerprinting Markets 2LaunchKey Raises $3 Million in Additional Funding Led by Metamorphic Ventures 2LaunchKey Raises $3 Million in Additional Funding Led by Metamorphic Ventures 3Global Chemical Sensor Market 2015-2019: Key Vendors are Abbott Laboratories, Bayer, Hoffmann La-Roche, Johnson & Johnson, NGK Spark Plugs and Robert Bosch 2
... to expand at a record pace with the addition of ... provides data on nearly half of all described species, with ... the International Union for the Conservation of Nature (IUCN) and ... In the four years since its first release, EOL ...
... Durham, NC The toothiest prehistoric predators also had beefier ... may come to mind, but these extinct cats weren,t the ... also known as nimravids and their catlike cousins, ... of these mammal groups lived millions of years before cats ...
... science have been discovered on the seafloor near Antarctica, ... The discoveries, made by teams led by the ... Survey, include new species of yeti crab, starfish, barnacles, ... first time, researchers have used a Remotely Operated Vehicle ...
Cached Biology News:The Encyclopedia of Life expanding at a record pace 2Prehistoric predators with supersized teeth had beefier arm bones 2Prehistoric predators with supersized teeth had beefier arm bones 3'Lost world' discovered around Antarctic vents 2
(Date:12/22/2014)... Dec. 22, 2014  ( www.competitivehealth.com ) — Competitive ... medical bill review and advocacy service, has signed an ... WellCard Savings discount health services marketplace. 63% ... more than they expected to pay. As part of ... costs, WellCard Savings is pleased to offer medical bill ...
(Date:12/22/2014)... 22, 2014 Fertility Associates of Memphis ... Bank USA , a network of more than 20 ... partnership, patients have fast access to a national pool ... IVF . Fertility Associates of Memphis is the only ... treatment option. , Dr. William Kutteh , director ...
(Date:12/19/2014)... BioPlus Specialty Pharmacy (BioPlus), one ... of Nick Maroulis, Pharm.D. to the newly created position ... In this position, Dr. Maroulis will continue to manage ... of our multi-site pharmacies as the company expands. Dr. ... that time he has served in many different capacities ...
(Date:12/19/2014)... Dec. 19, 2014 Bina Technologies, Inc. (Bina, ... that they have been acquired by Roche (SIX: RO, ... privately held company that provides a big data platform ... (NGS) data for the academic and translational research markets. ... and will continue to focus on development of their ...
Breaking Biology Technology:WellCard Savings Announces CoPatient Medical Bill Review Service for Members 2Fertility Associates of Memphis Announces Partnership with Donor Egg Bank USA 2Fertility Associates of Memphis Announces Partnership with Donor Egg Bank USA 3BioPlus Specialty Pharmacy Promotes Dr. Nick Maroulis to Vice President of Specialty Pharmacy Services 2Bina Technologies is acquired by Roche. 2Bina Technologies is acquired by Roche. 3
... , NEW YORK, Nov. ... research report is available in its catalogue. , ... Perspective , http://www.reportlinker.com/p0164375/Biotechnology-Reagents---A-Global-Market-Perspective.html#utm_source=prnewswire&utm_medium=pr&utm_campaign=prnewswire ... chemical compounds used in a range of biotech ...
... , MONROVIA, Calif. and HANGZHOU, China, Nov. 18 ... "Company") (OTC Bulletin Board: NIUS), a leading U.S.-based biotech company ... announced that the Company,s popular Gummy Bear products will be ... has entered into a one year distribution contract with Hainan ...
... AMSTERDAM, November 18 , ... Heart,Association , Amsterdam Molecular Therapeutics (EuroNext Amsterdam: ... its non-audited business,update in compliance with the EU transparency directive. This ... 2009. , Q3 2009 Highlights, ...
Cached Biology Technology:Reportlinker Adds Biotechnology Reagents - A Global Market Perspective 2Reportlinker Adds Biotechnology Reagents - A Global Market Perspective 3Reportlinker Adds Biotechnology Reagents - A Global Market Perspective 4Reportlinker Adds Biotechnology Reagents - A Global Market Perspective 5Reportlinker Adds Biotechnology Reagents - A Global Market Perspective 6Reportlinker Adds Biotechnology Reagents - A Global Market Perspective 7Reportlinker Adds Biotechnology Reagents - A Global Market Perspective 8Niusule Expands Geographic Footprint in China 2Niusule Expands Geographic Footprint in China 3AMT Provides Business Update for the Third Quarter 2009 2AMT Provides Business Update for the Third Quarter 2009 3AMT Provides Business Update for the Third Quarter 2009 4
Human alpha-1-antitrypsin. No cross-reactivity with alpha-1-acid glycoprotein, serum albumin or other serum proteins....
Phosphorylcholine hapten is conjugated to BSA protein by use of p-diazonium phenylphosphorylcholine....
Viral CMV UL146/vCXC1 Biotinylated Affinity Purified PAb...
Blue Standard is 3-cyano-7-hydroxycoumarin....
Biology Products: