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Gene that helps mosquitoes fight off malaria parasite identified

search Institute at the Bloomberg School of Public Health.

"These results provided new insights into how the mosquito defends itself from the malaria parasite. More research is needed, but we plan to apply this knowledge in the development of new approaches to control the disease," said co-author Marcelo Jacobs-Lorena, PhD, a professor in the Department of Molecular Microbiology and Immunology and the Malaria Research Institute at the Bloomberg School of Public Health.

Abraham and Jacobs-Lorena are developing a transgenic mosquito in which the SPRN6 gene is permanently switched on, in an effort to create a mosquito that would be immune to the Plasmodium parasite. They believe that such a mosquito could help disrupt the transmission of malaria to humans.

"An immune-responsive serpin, SRPN6, mediates mosquito defense against malaria parasites" was written by Eappen G. Abraham, Sofia Pinto, Anil Ghosh, Dana L. Vanlandingham, Aidan Budd, Stephen Higgs, Fotis C. Kafatos, Marcelo Jacobs-Lorena and Kristin Michel. Abraham, Ghosh and Jacobs-Lorena are with the Johns Hopkins Bloomberg School of Public Health. Pinto, Budd, Kafatos and Michel are with the European Molecular Biology Laboratory in Heidelberg, Germany and the Imperial College of London. Vanlandingham and Higgs are with the Department of Pathology at the University of Texas Medical Branch.


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Source:Johns Hopkins University Bloomberg School of Public Health


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