Navigation Links
Gene that helps mosquitoes fight off malaria parasite identified

Researchers have identified a gene in mosquitoes that helps the insects to fight off infection by the Plasmodium parasite, which causes malaria in humans. Anopheles mosquitoes transmit the malaria parasite to nearly 550 million people worldwide each year with these cases resulting in more than 2 million deaths annually. The protective gene was identified in a study conducted by a team of investigators from the Johns Hopkins Bloomberg School of Public Health's Malaria Research Institute, the Imperial College of London and the University of Texas Medical Branch. It will be published in the Online Early Edition of the Proceedings of the National Academy of Sciences the week of October 24.

The malaria-causing Plasmodium has a complex life cycle. Mosquitoes become infected with the parasite when they draw blood from humans who have malaria. As the parasite matures, it moves from the mosquito's midgut to its salivary glands. Once in the salivary glands, the Plasmodium can be injected into another human when the mosquito feeds again.

In the study, the researchers determined that the SPRN6 gene, which is normally switched off in Anopheles stephensi and Anopheles gambiae mosquitoes, is switched on when they are infected with the malaria parasite. To determine the function of SPRN6, the researchers deactivated the gene in the mosquitoes through a process called RNA interference. They observed that the number of parasites that developed in Anopheles stephensi mosquitoes increased three-fold when the gene was knocked out. In Anopheles gambiae mosquitoes, removing the SPRN6 gene delayed the process of parasite lysis, whereby the mosquito rids itself of the parasite.

"This study furthers our knowledge of the malaria-parasite lysis in mosquitoes. It may help provide better tools for controlling the disease in the future," said lead author Eappen G. Abraham, PhD, research associate in the Department of Molecular Microbiology and Immunology and the Malaria Re
'"/>

Source:Johns Hopkins University Bloomberg School of Public Health


Page: 1 2

Related biology news :

1. Jumping gene helps explain immune systems abilities
2. Protein helps regulate the genes of embryonic stem cells
3. Scientists reveal the shape of a protein that helps retroviruses break into cells
4. Thai spice helps cut blood sugar swings
5. Chemists synthesize molecule that helps body battle cancers, malaria
6. Ancient DNA helps clarify the origins of two extinct New World horse species
7. Massey Cancer Center researcher helps to identify a piece of the cancer puzzle
8. Study: Well-known protein helps stem cells become secretory cells
9. Beyond genes: Lipid helps cell wall protein fold into proper shape
10. Simple sea sponge helps scientists understand tissue rejection
11. New technique helps identify multiple DNA regulatory sites
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Gene that helps mosquitoes fight off malaria parasite identified

(Date:4/16/2014)... to blame for significant baseline levels of arsenic in ... in the Journal of Environmental Quality . , ... of Ohio showed that every single sample had concentrations ... the U.S. Environmental Protection Agency. The findings should not ... regulatory levels typically are set far below those thought ...
(Date:4/15/2014)... and energy for nearly all life on Earth, yet ... example, little is known about how it is regulated ... we do not know the full list of the ... any organism. , , A type of single-cell green ... subject for photosynthesis research. Despite its importance in the ...
(Date:4/15/2014)... Worcester, Mass. Diana Lados, associate professor ... (WPI) and founding director of the university,s ... two major career achievement awards from leading ... in Detroit, SAE International, a global association ... technical experts in the automotive, aerospace, and ...
Breaking Biology News(10 mins):Significant baseline levels of arsenic found in Ohio soils are due to natural processes 2Significant baseline levels of arsenic found in Ohio soils are due to natural processes 3Significant baseline levels of arsenic found in Ohio soils are due to natural processes 4WPI's Diana Lados honored by SAE International and Minerals, Metals, and Materials Society 2WPI's Diana Lados honored by SAE International and Minerals, Metals, and Materials Society 3WPI's Diana Lados honored by SAE International and Minerals, Metals, and Materials Society 4WPI's Diana Lados honored by SAE International and Minerals, Metals, and Materials Society 5
... Jerusalem, November 21, 2010 Research work carried out ... warning in the growing field of the development of ... patients through replacement of diseased or damaged tissues by ... a possible danger of cancerous tissue development in the ...
... Consortium (IVCC) has received $50 million from the Bill ... develop new insecticides for the improved control of mosquitoes ... neglected tropical diseases. IVCC was established ... over five years from the foundation. Since then, ...
... prompts normal cells to transform themselves into cancerous cells? Researchers ... Antonio, have identified factors in the very first step of ... tube. The latter accomplishment was reported Sunday [Nov. 21] in ... The DNA molecule the elegant, twin-stranded necklace of ...
Cached Biology News:Hebrew University research carries cautionary warning for future stem cell applications 2Hebrew University research carries cautionary warning for future stem cell applications 3
(Date:1/14/2014)... Boston, MA (PRWEB) January 14, 2014 ... today announces Michelle Detwiler as the new Director of ... current and potential clients as well as iLab sub-teams ... main goal will be to ensure that iLab provides ... offering the most advanced, user-friendly, and high-impact solution in ...
(Date:1/14/2014)... WESTBOROUGH, Mass. , Jan. 14, 2014 ... biotechnology company focused on discovering, developing and ... needs using RNA-targeted technologies, today announced that ... the United States Patent and Trademark Office ... for the treatment of fibrosis. The patent ...
(Date:1/14/2014)... , Jan. 14, 2014   Kinaxis ®, ... management ( SCM ) and sales and operations planning ... gold sponsor of the Biomanufacturing Summit , which ... January 30 – 31, 2014.  At the conference, join ... Chain at Amgen, as she presents ,Supply Chain: Improving ...
(Date:1/14/2014)... Kerr Corporation, a leading manufacturer of innovative dental products, ... dual arch impressions on its dental blog. , ... entry serves up a list of tips to help dentists ... Dr. David Little as he crafts a porcelain crown using ... as the dual arch dental impression material . ...
Breaking Biology Technology:iLab Solutions Announces Michelle Detwiler as the New Director of Product Strategy 2RXi Pharmaceuticals Receives US Notice of Allowance for a Key Patent Relating to its Self-Delivering Technology with sd-rxRNAs targeting CTGF, including RXI-109, for the Treatment of Fibrotic Disorders 2RXi Pharmaceuticals Receives US Notice of Allowance for a Key Patent Relating to its Self-Delivering Technology with sd-rxRNAs targeting CTGF, including RXI-109, for the Treatment of Fibrotic Disorders 3Event Alert: Kinaxis Customer to Present at the Biomanufacturing Summit "Supply Chain: Improving Network Effectiveness" 2
... Pressure BioSciences, Inc. (Nasdaq: PBIO ) ... announced that they have entered into a strategic marketing, ... the Agreement, the companies will: (1) share market data, ... certain products at industry trade shows beginning in 2009; ...
... http://www.wellcentive.com ),today announced the launch of two new ... securely and cost-effectively share patient,data within a community ... such as physicians, to easily access patient data ... Connect is a health care technology platform,which receives ...
... NEW YORK, Dec. 11 Delcath Systems, Inc. (Nasdaq: ... its proprietary Percutaneous Hepatic Perfusion ("PHP") System for the treatment ... fifty percent (46 of 92) of patients have been enrolled ... ocular melanoma to the liver. The eleven participating cancer ...
Cached Biology Technology:Pressure BioSciences, Inc. and Omni International Announce Marketing, Distribution, and Technology Development Agreement 2Pressure BioSciences, Inc. and Omni International Announce Marketing, Distribution, and Technology Development Agreement 3Pressure BioSciences, Inc. and Omni International Announce Marketing, Distribution, and Technology Development Agreement 4Pressure BioSciences, Inc. and Omni International Announce Marketing, Distribution, and Technology Development Agreement 5WellCentive Launches New Health Information Exchange Platforms 2WellCentive Launches New Health Information Exchange Platforms 3Enrollment in Delcath's Pivotal Phase III Metastatic Melanoma Clinical Trial Reaches Halfway Point 2Enrollment in Delcath's Pivotal Phase III Metastatic Melanoma Clinical Trial Reaches Halfway Point 3
COMING SOON: Anti-Mouse C5/C5b, Clone BB5.1. Monoclonal Antibody...
... Goat anti-Human Alpha 1 Acid ... azide Goats were immunized ... glycoprotein in Freund's adjuvant. ... absorbed to ensure specificity. ...
Anti-Mouse Valpha 2 TCR, Purified (Clone B20.1) (rat IgG2a)...
Request Info...
Biology Products: