Navigation Links
Gene tests and brain imaging reveal early dementia

Dementia diseases develop insidiously and are generally discovered when the memory has already started to deteriorate. New research form Karolinska Institutet shows, however, that approaching Alzheimer's can be detected several years before the symptoms manifest themselves.

Dementia involves a serious deterioration of mental function caused by some kind of dementia disease of the brain, of which Alzheimer's is the most common. Although there is currently no cure for Alzheimer's, it is possible to inhibit its development if the treatment is given early enough. However, with today's diagnostics, it is very difficult to identify people with early Alzheimer's.

A new doctoral thesis by Johanna Lind, Karolinska Institutet in Sweden, now shows that genetic mapping and brain imagery can be used to identify people who will develop dementia even before any clinical symptoms appear.

"This is a crucial step towards the better diagnosis of Alzheimer's," she says. "If the method is developed it can help us find the people who'd benefit most from treatment in good time."

The method is based on the well-established fact that the APOE protein affects the risk of developing Alzheimer's. APOE is a lipid-transporting protein important in, amongst other things, the repair of cerebral neurons. Roughly one person in five carries a genetically determined variant of APOE that is associated with an increased risk of Alzheimer's.

In her study, Johanna Lind was able to show that some of the people in this risk group had reduced parietal lobe activity, detectable using an MR camera, and that these same people were the ones who went on to suffer memory deterioration two to three years later.

"It's surprisingly difficult to diagnose Alzheimer's with any certainty, but things are made easier if you know who runs the greatest risk," she says. "If genetic mapping, MRI and cognitive tests all suggest approaching Alzheimer's, it might be an idea to start a course of treatment."


'"/>

Source:Karolinska Institutet


Related biology news :

1. Transgenic plants remove more selenium from polluted soil than wild plants, new tests show
2. UN successfully tests green pesticide against locusts
3. Human trial proves ricin vaccine safe, induces neutralizing antibodies; further tests planned
4. Free HIV tests cheaper than charging when goal is preventing AIDS
5. Embryo tests give parents the choice
6. Chemical tests of cell growth enter third dimension
7. Light-based probe sees early cancers in first tests on human tissue
8. Soft-cell approach cuts animal tests
9. Controversial drug shown to act on brain protein to cut alcohol use
10. Mouse brain cells rapidly recover after Alzheimers plaques are cleared
11. Mouse brain tumors mimic those in human genetic disorder
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:12/22/2016)... December 22, 2016 SuperCom (NASDAQ: ... solutions for the e-Government, Public Safety, HealthCare, and Finance sectors announced ... has been selected to implement and deploy a community-based supportive services ... Northern California , further expanding its presence in the state. ... This new program, ...
(Date:12/20/2016)... N.C. and GENEVA, Dec, 20, 2016 /PRNewswire/ ... biometric data sensor technology, and STMicroelectronics ... the spectrum of electronics applications, announced today the ... development kit for biometric wearables that includes ST,s ... with Valencell,s Benchmark™ biometric sensor system. ...
(Date:12/16/2016)... MIAMI , Dec. 16, 2016   ... intuitive Identity management products and solutions and a ... announced today that it is offering seamless, integrated ... Edam security entrance products. The solutions provide IdentyTech,s ... to secure their facilities from crime and theft. ...
Breaking Biology News(10 mins):
(Date:1/16/2017)... Ky. , Jan. 16, 2017  Eurofins Genomics ... which will allow more customers to receive their primers ... premium or compromise in quality found with other providers. ... the United States at no additional fee. ... of routine genetic studies, including DNA sequencing, genotyping, site-directed ...
(Date:1/13/2017)... Research and Markets has announced the addition of the "Global Biopolymers ... ... of 16.83% during the period 2017-2021. The report covers ... for 2017-2021. To calculate the market size, the report considers the revenue ... includes a a discussion of the key vendors operating in this market. ...
(Date:1/12/2017)... ... January 12, 2017 , ... ... , VTI, Vertebral Technologies, Inc., announces the successful outcome of the first ... September 2016, VTI (Vertebral Technologies, Inc.) has partnered with Mexico-based medical product ...
(Date:1/12/2017)... ... January 12, 2017 , ... ... treatments, 26-year-old Lisa Rosendahl’s doctors gave her only a few months to live. ... drug combination that has stabilized Rosendahl’s disease and increased both the quantity and ...
Breaking Biology Technology: