Navigation Links
Gene tests and brain imaging reveal early dementia

Dementia diseases develop insidiously and are generally discovered when the memory has already started to deteriorate. New research form Karolinska Institutet shows, however, that approaching Alzheimer's can be detected several years before the symptoms manifest themselves.

Dementia involves a serious deterioration of mental function caused by some kind of dementia disease of the brain, of which Alzheimer's is the most common. Although there is currently no cure for Alzheimer's, it is possible to inhibit its development if the treatment is given early enough. However, with today's diagnostics, it is very difficult to identify people with early Alzheimer's.

A new doctoral thesis by Johanna Lind, Karolinska Institutet in Sweden, now shows that genetic mapping and brain imagery can be used to identify people who will develop dementia even before any clinical symptoms appear.

"This is a crucial step towards the better diagnosis of Alzheimer's," she says. "If the method is developed it can help us find the people who'd benefit most from treatment in good time."

The method is based on the well-established fact that the APOE protein affects the risk of developing Alzheimer's. APOE is a lipid-transporting protein important in, amongst other things, the repair of cerebral neurons. Roughly one person in five carries a genetically determined variant of APOE that is associated with an increased risk of Alzheimer's.

In her study, Johanna Lind was able to show that some of the people in this risk group had reduced parietal lobe activity, detectable using an MR camera, and that these same people were the ones who went on to suffer memory deterioration two to three years later.

"It's surprisingly difficult to diagnose Alzheimer's with any certainty, but things are made easier if you know who runs the greatest risk," she says. "If genetic mapping, MRI and cognitive tests all suggest approaching Alzheimer's, it might be an idea to start a course of treatment."


'"/>

Source:Karolinska Institutet


Related biology news :

1. Transgenic plants remove more selenium from polluted soil than wild plants, new tests show
2. UN successfully tests green pesticide against locusts
3. Human trial proves ricin vaccine safe, induces neutralizing antibodies; further tests planned
4. Free HIV tests cheaper than charging when goal is preventing AIDS
5. Embryo tests give parents the choice
6. Chemical tests of cell growth enter third dimension
7. Light-based probe sees early cancers in first tests on human tissue
8. Soft-cell approach cuts animal tests
9. Controversial drug shown to act on brain protein to cut alcohol use
10. Mouse brain cells rapidly recover after Alzheimers plaques are cleared
11. Mouse brain tumors mimic those in human genetic disorder
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/24/2017)... , March 24, 2017 The Controller General ... Controller Mr. Abdulla Algeen have received the prestigious international IAIR ... Continue Reading ... ... picture) and Deputy Controller Abdulla Algeen (small picture on the right) have ...
(Date:3/23/2017)... PUNE, India , March 23, 2017 The report ... Equipment, Touchless Biometric), Industry, and Geography - Global Forecast to 2022", published by ... growing at a CAGR of 29.63% between 2017 and 2022. ... ... Logo ...
(Date:3/22/2017)...   Neurotechnology , a provider of high-precision ... the release of the SentiVeillance 6.0 ... recognition using up to 10 surveillance, security and ... new version uses deep neural-network-based facial detection and ... a Graphing Processing Unit (GPU) for enhanced speed. ...
Breaking Biology News(10 mins):
(Date:6/26/2017)... ... June 26, 2017 , ... Third Wave Bioactives, LLC announces the addition ... on leading new business development and ensuring quality customer experience. , Brett ... ingredient industry in technical, marketing and sales roles. “Brett’s background working with customers and ...
(Date:6/23/2017)... ... June 23, 2017 , ... Biova, LLC., the leader in ... Biova’s Board of Directors. Dr. Henig will bring a wealth of scientific experience in ... as the Chief Technical and Scientific Officer of four major global companies in the ...
(Date:6/23/2017)... Ringle, WI (PRWEB) , ... ... ... MedJobCafe.com announce the launch of a redesigned, easier-to-navigate website for all six ... job boards for physicians, nurses, dentists, pharmacists, physical and occupational therapists, and ...
(Date:6/22/2017)... ... June 21, 2017 , ... RMC Pharmaceutical Solutions, ... engages Timothy Reinhardt to manage the new site. , Tim has 25 years ... his most recent role as the Director of Manufacturing and Supplier Quality Assessment. ...
Breaking Biology Technology: