Navigation Links
Gene-specific Ebola therapies protect non-human primates from lethal disease

Scientists have developed a successful strategy for interfering with Ebola virus infection that protected 75 percent of nonhuman primates exposed to the lethal disease. This is the first successful antiviral intervention against filoviruses like Ebola in nonhuman primates. The findings could serve as the basis for a new approach to quickly develop virus-specific therapies for known, emerging, and genetically engineered pathogens.

In today's online issue of the journal Public Library of Science Pathogens, a research team led by Sina Bavari and colleagues at the U.S. Army Medical Research Institute of Infectious Diseases (USAMRIID) reports using novel "antisense" drugs to interrupt normal Ebola virus replication. The work was performed in collaboration with AVI BioPharma, a U.S. biotechnology firm.

According to the study's authors, antisense drugs are useful against viral diseases because they are designed to enter cells and eliminate viruses by preventing their replication. The drugs, which act by blocking critical viral genetic sequences, may be more potent than anti-virals such as protease inhibitors, which seek to inhibit a protein needed for viral replication.

Ebola virus causes hemorrhagic fever with case fatality rates as high as 80 percent in humans. The virus, which is infectious by aerosol (although more commonly spread through blood and bodily fluids of infected patients), is of concern both as a global health threat and a potential agent of biological warfare or terrorism. Currently there are no available vaccines or therapies.

"One advantage of this strategy is that it directly targets the virus," said the paper's first author, Kelly L. Warfield. "With Ebola infection, the virus grows so fast that it overtakes the host immune system. What we did, essentially, was to hold off the viral replication long enough for the host to mount an immune response and clear the virus."

Working with a class of compounds known as
'"/>

Source:US Army Medical Research Institute of Infectious Diseases


Page: 1 2

Related biology news :

1. Study Links Ebola Outbreaks To Animal Carcasses
2. Scientists discover how Ebola virus infects cells
3. Ebola virus: from wildlife to dogs
4. Poaching, logging, and outbreaks of Ebola threaten central African gorillas and chimpanzees
5. Ebola DNA vaccine produces immune responses in all fully vaccinated volunteers in Phase 1 trial
6. Gorilla susceptibility to Ebola virus: the cost of sociality
7. Researchers discover key mechanism by which lethal viruses Ebola and Marburg cause disease
8. Pattern of human Ebola outbreaks linked to wildlife and climate
9. Ebola-outbreak kills 5000 gorillas
10. Ebola outbreaks killing thousands of gorillas and chimpanzees
11. Hopkins AIDS experts issue warning about global efforts to provide drug therapies
Post Your Comments:
(Date:8/5/2015)... 2015 According to a new ... Software, Services, Vertical (BFSI, Airport, IT & Telecom, Utilities, ... Forecast to 2020", published by MarketsandMarkets, defines and segments ... various segments. The global PIAM Market is estimated to ... by 2019, at a CAGR of 14.9 % from ...
(Date:8/5/2015)... The biosensors market is proving highly attractive ... newer sectors, and development of devices resulting in higher ... seen the entry of multiple participants each year with ... (Photo - http://photos.prnewswire.com/prnh/20150805/255570 ) Recent ... Global Biosensors Market ( http://www.frost.com/nee9 ), finds that ...
(Date:8/4/2015)... Aug. 4, 2015  AMRI (NASDAQ: AMRI ) today reported ... 2015. Highlights: , Second quarter contract revenue ... 2014 , Adjusted contract margins of ... $0.22, including a $0.05 decrease in EPS from royalties in the ... million "We are very pleased to present another ...
Breaking Biology News(10 mins):Physical Identity and Access Management Market Worth $546.2 Million by 2019 2Physical Identity and Access Management Market Worth $546.2 Million by 2019 3Physical Identity and Access Management Market Worth $546.2 Million by 2019 4Innovative Biosensors Incite Use in Non-Traditional Applications 2Innovative Biosensors Incite Use in Non-Traditional Applications 3Innovative Biosensors Incite Use in Non-Traditional Applications 4AMRI Announces Second Quarter 2015 Results 2AMRI Announces Second Quarter 2015 Results 3AMRI Announces Second Quarter 2015 Results 4AMRI Announces Second Quarter 2015 Results 5AMRI Announces Second Quarter 2015 Results 6AMRI Announces Second Quarter 2015 Results 7AMRI Announces Second Quarter 2015 Results 8AMRI Announces Second Quarter 2015 Results 9AMRI Announces Second Quarter 2015 Results 10AMRI Announces Second Quarter 2015 Results 11AMRI Announces Second Quarter 2015 Results 12AMRI Announces Second Quarter 2015 Results 13AMRI Announces Second Quarter 2015 Results 14AMRI Announces Second Quarter 2015 Results 15AMRI Announces Second Quarter 2015 Results 16AMRI Announces Second Quarter 2015 Results 17AMRI Announces Second Quarter 2015 Results 18AMRI Announces Second Quarter 2015 Results 19AMRI Announces Second Quarter 2015 Results 20AMRI Announces Second Quarter 2015 Results 21AMRI Announces Second Quarter 2015 Results 22AMRI Announces Second Quarter 2015 Results 23AMRI Announces Second Quarter 2015 Results 24
... at the University of Leeds are developing methods of ... organic chemicals such as vinegar. , The harmful ... waste from former textiles factories, smelters, and tanneries have ... to problems with the kidneys, liver, lungs and skin. ...
... 3, 2009) When it comes to solving complex ... engineer, looks to nature for solutions. Finding inspiration in ... helping to tackle one of society,s biggest challenges: improving ... the survival rate of cancer patients. Today, ...
... March 2, 2009 Two researchers at UT ... Research Fellows, an award intended to "support the work ... and often at pivotal stages in their work." ... for their work in chemistry. The Alfred P. Sloan ...
Cached Biology News:Cleansing toxic waste -- with vinegar 2MIT student develops new innovations to selectively kill cancer cells 2MIT student develops new innovations to selectively kill cancer cells 3MIT student develops new innovations to selectively kill cancer cells 4Two UT Southwestern researchers awarded Sloan fellowships 2
(Date:9/1/2015)... ... September 01, 2015 , ... ... University of California Los Angeles, Boston University School of Medicine, Frederick National Laboratory ... PLOS One, the world’s first multidisciplinary Open Access journal. , Christopher Ryan ...
(Date:9/1/2015)... Shire plc (LSE: SHP, NASDAQ: ... to its Board of Directors as a Non-Executive Director. Sara ... Risk Committee of the Shire Board. Both appointments will be ... served as Chairman, President and Chief Executive Officer of Dun ... 12-year tenure at D&B, she helped drive the transformation of ...
(Date:8/31/2015)... - BIOREM Inc. (TSXV: BRM) ("Biorem" or "the Company") today ... air emission abatement projects in North America ... for a municipality in the Southern USA ... that failed to meet the customer,s requirements. This demonstrates the value ... S. Webb , President and Chief Executive Officer.  ...
(Date:8/31/2015)... DIEGO , Aug. 31, 2015 MabVax ... development company announces that the Company,s lead antibody, HuMab ... of five separate presentations during the upcoming World Molecular ... September 2-5, 2015. Researchers from the Department ... will present results on the use of MabVax,s lead ...
Breaking Biology Technology:Synedgen’s Director for Pharmaceutical Manufacturing Publishes New Research 2Synedgen’s Director for Pharmaceutical Manufacturing Publishes New Research 3Shire Appoints Sara Mathew to Board of Directors 2MabVax Therapeutics HuMab 5B1 Antibody Is Highlighted at Upcoming World Molecular Imaging Congress in Five Separate Presentations 2MabVax Therapeutics HuMab 5B1 Antibody Is Highlighted at Upcoming World Molecular Imaging Congress in Five Separate Presentations 3MabVax Therapeutics HuMab 5B1 Antibody Is Highlighted at Upcoming World Molecular Imaging Congress in Five Separate Presentations 4
... first-cycle,approval for a new molecular entity (NME) is ... average, according to a new analysis from,PAREXEL Consulting, ... PRXL ),and leading global life sciences consultancy serving ... PAREXEL Consulting,analysis, 60 percent of sales for newly-approved ...
... Medical and Security Detection Applications, ST. LOUIS, ... SAFC(R), a member of the Sigma-Aldrich Group (Nasdaq: ... the scope of its electronic materials,offering with the ... http://www.safchitech.com/halides ). These new raw materials enable the,growth ...
... ... Nutrition and Disease Research, KANNAPOLIS, N.C. ... Research Institute (DHMRI), located at the North,Carolina Research Campus ... that Waters(R) has been selected as the institute,s,primary supplier ...
Cached Biology Technology:PAREXEL Consulting Quantifies Speed to Market: First-Cycle Approval for NME Produces $640 Million in Incremental Revenue on Average 2PAREXEL Consulting Quantifies Speed to Market: First-Cycle Approval for NME Produces $640 Million in Incremental Revenue on Average 3PAREXEL Consulting Quantifies Speed to Market: First-Cycle Approval for NME Produces $640 Million in Incremental Revenue on Average 4PAREXEL Consulting Quantifies Speed to Market: First-Cycle Approval for NME Produces $640 Million in Incremental Revenue on Average 5SAFC Hitech(TM) Expands Electronic Materials Portfolio With the Introduction of Scintillation Crystal Growth Halides 2SAFC Hitech(TM) Expands Electronic Materials Portfolio With the Introduction of Scintillation Crystal Growth Halides 3SAFC Hitech(TM) Expands Electronic Materials Portfolio With the Introduction of Scintillation Crystal Growth Halides 4David H. Murdock Research Institute Taps Waters for Laboratory Technology 2David H. Murdock Research Institute Taps Waters for Laboratory Technology 3
... separation and fractionation of nucleic-acid ... nuclei from cytosolic proteins A ... greatly facilitating study of low-abundance ... acid binding proteins (e.g., transcription ...
... was developed for culturing hybrid cells that ... consists of doubling the amino acids and ... concentrations have been altered as well. This ... liter, which may render it unsuitable for ...
... is an 18 amino acid synthetic peptide whose sequence corresponds to ... peptide is (amino to carboxy terminus): M(1) - A - S ... A - S - P - R - D - A ... peptide may be used for neutralization and control experiments with the ...
... EpiTect Bisulfite Kit enables complete conversion ... less than 6 hours. The highly ... against DNA degradation and a spin-column-based ... fast and reliable results for all ...
Biology Products: