Navigation Links
Gene screen for breast cancer better than pathologist's 'eye'

Johns Hopkins scientists have found that a method they developed to screen body fluids for certain kinds of cells and some of their genetic blueprint is twice as accurate at spotting breast cancer cells as a pathologist's view with a microscope.

The screen, developed by Sara Sukumar, Ph.D. and Mary Jo Fackler, Ph.D., first separates cells from fluid, then sifts through the cells' DNA for chemical tags on certain genes associated with cancer.

Reporting in the June 1 issue of Clinical Cancer Research, the scientists say they have tested their screening tool on breast fluid, in search of cells shed from growing tumors.

"This screening method can see what the eye cannot see," says Sukumar, who is the Barbara B. Rubenstein Professor of Oncology at the Johns Hopkins Kimmel Cancer Center. "It can be a valuable tool, in combination with pathological review, for breast cancer as well as other diseases where fluid can be obtained relatively easily, such as lung, head and neck cancers, pancreatic and cervical cancers."

Pathologists look for telltale shapes of cells to determine if cancer is present, but molecular changes in cells, especially for early cancers, are beyond the reach of even the most powerful microscopes.

Sukumar's test searches for unusually high amounts of chemical tags embedded by a process called methylation within critical regions of DNA. The tags attach to the "on" switch of genes which starts the message-manufacturing process. Cancer cells have abnormal levels of methylation, which turns the gene switch off halting the assembly line of critical proteins found in normal cells.

The Hopkins test, called quantitative multiplex methylation-specific PCR or QM-MSP, determines the percentage of methylation present in each of five to ten cancer genes. The percentages are added together for a cumulative score, which is compared to a threshold value. Levels above the threshold indicate the potential presen
'"/>

Source:Johns Hopkins Medical Institutions


Page: 1 2

Related biology news :

1. MetaChip provides quick, efficient toxicity screening of potential drugs
2. Boosting HIV screening can increase survival and is cost effective
3. Researchers develop assay that could be applied to drug screening
4. Aptamer-based Biosensor screens Air Force personnel and equipment
5. NIH creates nationwide network of molecular libraries screening centers
6. UT Southwestern researchers develop screening test for cells that activate immune system
7. Newborn screening can cause unnecessary parental stress
8. Handling HPV vaccines and screening: The views of 100 authors
9. Pesticides need sunscreen to beat the heat
10. New sunscreen ingredient to heal sunburn and help prevent skin cancer
11. Hair-growth drug artificially lowers PSA levels in prostate cancer screening, study finds
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Gene screen for breast cancer better than pathologist eye

(Date:7/11/2014)... to study the proteins that let nerve cells send ... stumbled upon a biological tactic that may offer a ... a safe and environmentally responsible way. , Their ... one species and harmless for a closely related onesuggests ... without harming beneficial species like bees. A summary of ...
(Date:7/11/2014)... In the brains of all vertebrates, information is ... electric or chemical signal to be passed from ... are the most abundant type of synapse, can ... crucial for learning, memory, perception and cognition, and ... for brain function. For instance, every time ...
(Date:7/10/2014)... in New Mexico, nearly every public golf course is ... potable water supplies. Across the U.S. Southwest as a ... treated effluent. Reusing the effluent increases the sustainability of ... alike fertilize their lawns during the growing season. The ... State University turfgrass expert has a new vision for ...
Breaking Biology News(10 mins):Potent spider toxin 'electrocutes' German, not American, cockroaches 2Potent spider toxin 'electrocutes' German, not American, cockroaches 3Blame it on the astrocytes 2'Tailored' water -- the latest in lawn care 2
... Friday, October 7, 2011, Cleveland: Researchers have ... diseases like asthma, rheumatoid arthritis, psoriasis, inflammatory bowel ... this pathway may provide opportunities for tailored treatments ... of this pathway was the work of an ...
... researchers from the University of Modena and Reggio Emilia ... that in aphids the two X chromosomes have a different ... . Aphids are insects with a sex determination ... in females and a single X chromosome (XO) in males. ...
... Biological invasions, i.e. the spread of introduced, non-native species, ... bring out the importance of economic activities on ecological ... variety of the interaction of economics with invasion science ... problems. Three researchers, lead by Mark Williamson from ...
Cached Biology News:Chromosome inheritance? Not the same for all the chromosomes 2
(Date:7/10/2014)... 2014 Research and Markets ( http://www.researchandmarkets.com/research/s3bqj2/photonic ... "International Photonic Integrated Circuit (Monolithic Integration, Hybrid Integration, ... report to their offering. ... photonic integration traces its roots in the latter ... photonic integration went unexplored and unfulfilled for several ...
(Date:7/10/2014)... 15, 2014 -- According to the International Atomic ... security comes from terrorists acquiring sufficient quantities of ... a crude nuclear explosive device. The IAEA also ... have involved gram-level quantities, which can be challenging ... to a new study appearing this week in ...
(Date:7/10/2014)... Using microscopic polymer light resonators that expand ... MIT,s Quantum Photonics Laboratory have developed new optical ... range. Optical sensors are ideal for detecting trace ... compact, lightweight nature, and immunity to electromagnetic interference. ... developed before, the MIT team conceived an extremely ...
(Date:7/10/2014)... has been extremely challenging because there are many genetic ... cause disease. Now investigators reporting in the July 3rd ... Cell describe a strategy that may help reveal ... factors or environmental exposures to affect the development of ... that may predispose individuals to schizophrenia. , The ...
Breaking Biology Technology:International Photonic Integrated Circuit (Monolithic Integration, Hybrid Integration, Module Integration) Market - Forecasts to 2019 2Sensitive detection method may help impede illicit nuclear trafficking 2Swell new sensors 2New strategy could uncover genes at the root of psychiatric illnesses 2
... ... ... ... ...
... ... ... ... ...
... ... ... ... ...
Cached Biology Technology:Citius Tech Launches BI-Clinical MUSE for Advanced "Meaningful Use" Reporting and Data Submission, and Performance Management for Healthcare ISVs 2Citius Tech Launches BI-Clinical MUSE for Advanced "Meaningful Use" Reporting and Data Submission, and Performance Management for Healthcare ISVs 3Citius Tech Launches BI-Clinical MUSE for Advanced "Meaningful Use" Reporting and Data Submission, and Performance Management for Healthcare ISVs 4Elsevier Addresses Today's Healthcare Information Crisis With a Renewed Focus on Improving Quality and Efficiency 2Elsevier Addresses Today's Healthcare Information Crisis With a Renewed Focus on Improving Quality and Efficiency 3Elsevier Addresses Today's Healthcare Information Crisis With a Renewed Focus on Improving Quality and Efficiency 4Elsevier Addresses Today's Healthcare Information Crisis With a Renewed Focus on Improving Quality and Efficiency 5Elsevier Addresses Today's Healthcare Information Crisis With a Renewed Focus on Improving Quality and Efficiency 6Elsevier Addresses Today's Healthcare Information Crisis With a Renewed Focus on Improving Quality and Efficiency 7Elsevier Addresses Today's Healthcare Information Crisis With a Renewed Focus on Improving Quality and Efficiency 8Elsevier Addresses Today's Healthcare Information Crisis With a Renewed Focus on Improving Quality and Efficiency 9Peer-reviewed Articles Further Define Clusterin and the Role of a Clusterin Inhibitor, OGX-011, for the Treatment of Cancer 2Peer-reviewed Articles Further Define Clusterin and the Role of a Clusterin Inhibitor, OGX-011, for the Treatment of Cancer 3Peer-reviewed Articles Further Define Clusterin and the Role of a Clusterin Inhibitor, OGX-011, for the Treatment of Cancer 4Peer-reviewed Articles Further Define Clusterin and the Role of a Clusterin Inhibitor, OGX-011, for the Treatment of Cancer 5Peer-reviewed Articles Further Define Clusterin and the Role of a Clusterin Inhibitor, OGX-011, for the Treatment of Cancer 6Peer-reviewed Articles Further Define Clusterin and the Role of a Clusterin Inhibitor, OGX-011, for the Treatment of Cancer 7
Request Info...
Buffer used for mitocapture assays....
... Our entry-level automated perfusion system. For ... perfusion, physiology, biophysics, electrochemistry, or general ... with 10 millisecond accuracy Run ... Microprocessor-based for accuracy and flexibility ...
{3,8-diamino-5-[3-(diethylmethylammonio)propyl]-6-phenylphenanthridinium diiodide}. ,250 ug/ml Propidium Iodide (PI) in PBS....
Biology Products: