Navigation Links
Gene screen for breast cancer better than pathologist's 'eye'

Johns Hopkins scientists have found that a method they developed to screen body fluids for certain kinds of cells and some of their genetic blueprint is twice as accurate at spotting breast cancer cells as a pathologist's view with a microscope.

The screen, developed by Sara Sukumar, Ph.D. and Mary Jo Fackler, Ph.D., first separates cells from fluid, then sifts through the cells' DNA for chemical tags on certain genes associated with cancer.

Reporting in the June 1 issue of Clinical Cancer Research, the scientists say they have tested their screening tool on breast fluid, in search of cells shed from growing tumors.

"This screening method can see what the eye cannot see," says Sukumar, who is the Barbara B. Rubenstein Professor of Oncology at the Johns Hopkins Kimmel Cancer Center. "It can be a valuable tool, in combination with pathological review, for breast cancer as well as other diseases where fluid can be obtained relatively easily, such as lung, head and neck cancers, pancreatic and cervical cancers."

Pathologists look for telltale shapes of cells to determine if cancer is present, but molecular changes in cells, especially for early cancers, are beyond the reach of even the most powerful microscopes.

Sukumar's test searches for unusually high amounts of chemical tags embedded by a process called methylation within critical regions of DNA. The tags attach to the "on" switch of genes which starts the message-manufacturing process. Cancer cells have abnormal levels of methylation, which turns the gene switch off halting the assembly line of critical proteins found in normal cells.

The Hopkins test, called quantitative multiplex methylation-specific PCR or QM-MSP, determines the percentage of methylation present in each of five to ten cancer genes. The percentages are added together for a cumulative score, which is compared to a threshold value. Levels above the threshold indicate the potential presen
'"/>

Source:Johns Hopkins Medical Institutions


Page: 1 2

Related biology news :

1. MetaChip provides quick, efficient toxicity screening of potential drugs
2. Boosting HIV screening can increase survival and is cost effective
3. Researchers develop assay that could be applied to drug screening
4. Aptamer-based Biosensor screens Air Force personnel and equipment
5. NIH creates nationwide network of molecular libraries screening centers
6. UT Southwestern researchers develop screening test for cells that activate immune system
7. Newborn screening can cause unnecessary parental stress
8. Handling HPV vaccines and screening: The views of 100 authors
9. Pesticides need sunscreen to beat the heat
10. New sunscreen ingredient to heal sunburn and help prevent skin cancer
11. Hair-growth drug artificially lowers PSA levels in prostate cancer screening, study finds
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Gene screen for breast cancer better than pathologist eye

(Date:6/17/2015)... SAN JOSE, Calif. , June 17, 2015 ... leader in human interface solutions, today announced that ... has adopted the Synaptics ® ClearPad ® ... family of display driver integrated circuits (DDICs) for ... Note Pro. By leveraging ClearPad for full in-cell ...
(Date:6/16/2015)... 16, 2015 Fingerprint Cards (FPC) raises ... it will amount to at least 340 MSEK to that ... rapid increase in market growth and orders received the revenue ... that revenue for 2015 will exceed 1,500 MSEK to an ... 2,200 MSEK. Due to receipt of orders of ...
(Date:6/11/2015)... June 11, 2015 Daon, a global ... that its IdentityX Mobile Authentication Platform v4.0 has ... Alliance is an industry consortium launched in 2013 ... simpler, stronger authentication.  In order to receive certification, ... rigorous series of tests that measure compliance and ...
Breaking Biology News(10 mins):Synaptics Touchscreen and Display Driver IC Solutions Power Xiaomi's Latest Flagship Smartphones 2Synaptics Touchscreen and Display Driver IC Solutions Power Xiaomi's Latest Flagship Smartphones 3Fingerprint Cards Raises the Revenue Guidance for Q2 2015 and for the Full Year 2015 2Fingerprint Cards Raises the Revenue Guidance for Q2 2015 and for the Full Year 2015 3Daon's IdentityX Mobile Authentication Platform One of First Products to be Certified by FIDO Alliance 2
... Cold Spring Harbor, NY A rose by any ... confound scientists interested in understanding the chemical components of its ... That,s because in biology, an organism,s scientific (taxonomic) ... This data on the genetic, ecological, and agricultural particulars ...
... 31, 2012 WestPark Capital, Inc., a Los Angeles based ... non-exclusive engagement agreement with Alliqua, Inc.  During the term ... the company regarding business and finance, private and public ... its securities holders and provide introductions to investors. ...
... they do because large fish and urchins eat most of the ... has found that the greatest impact of all comes from an ... the journal Ecology Letters is the largest of its ... it was led by Associate Professor Alistair Poore, of the UNSW ...
Cached Biology News:New release of Web-based resource resolves confusion over plant names 2New release of Web-based resource resolves confusion over plant names 3WestPark Capital, Inc. Engaged By Alliqua, Inc. 2Grazing snails rule the waves 2
(Date:6/26/2015)... NEW YORK and MUMBAI, India ... (TCS), (BSE: 532540, NSE: TCS) a leading global IT ... has been designated as a Leader in Worldwide Life ... IDC, in the " IDC MarketScape: Worldwide Life Science ... 2015) report. The report evaluated eight ...
(Date:6/26/2015)... ... June 26, 2015 , ... DNA Genotek, a leading ... Technologies, Inc. (Nasdaq: OSUR) today announced that it has awarded grants to three ... Grant Program. The company has awarded its OMNIgene®•GUT fecal/stool collection kits ...
(Date:6/25/2015)... -- Last June, a dedicated global team of Ebola researchers ... genome sequencing. Their research, which was written on the research ... Cell (Park 2015) , reveals critical information about ... the recent Ebola outbreak. Today Authorea is pleased ... full edit history of the paper are available to ...
(Date:6/25/2015)... ... 2015 , ... The American Brain Tumor Association announced today ... Conference, Providing and Pursuing Answers: Advances in Research, Treatment and Care. The conference ... 24-25, 2015. , “As advances in research accelerate the arrival of precision medicine ...
Breaking Biology Technology:TCS Recognized as a Leader in Life Sciences R&D Risk-Based Monitoring by IDC MarketScape 2TCS Recognized as a Leader in Life Sciences R&D Risk-Based Monitoring by IDC MarketScape 3TCS Recognized as a Leader in Life Sciences R&D Risk-Based Monitoring by IDC MarketScape 4DNA Genotek Inc. Announces Recipients of Gut Microbiome Grant Program 2DNA Genotek Inc. Announces Recipients of Gut Microbiome Grant Program 3Open Science Takes Major Leap Forward 2Nationally Recognized Brain Tumor Experts to Speak at American Brain Tumor Association Patient and Family Conference 2
... Dendreon Corporation (Nasdaq: DNDN ) management will host a conference call ... second quarter 2009 financial results. Access to the discussion may be obtained as ... 11:30 AM ET /8:30 AM PT, Date: ... (domestic) or +1-719-325-4873 (international), Webcast: www.dendreon.com (homepage and investor ...
... , , , PITTSBURGH, July 30 ... the three and six months ended June 30, 2009. , , ... Adjusted diluted EPS, which excludes the impact of certain purchase accounting items ... $0.65 for the three and six months ended June 30, 2009, compared to $0.20 ...
... a weakened strain of the malaria parasite that will be ... developed in collaboration with researchers from the US, Japan and ... Malaria kills more than one million people each year and ... of at least 35 million years of healthy, productive human ...
Cached Biology Technology:Dendreon to Hold Conference Call on Tuesday, August 11, 2009 at 11:30 AM ET 2Mylan Reports Adjusted Diluted EPS of $0.32 for the Quarter Ended June 30, 2009 2Mylan Reports Adjusted Diluted EPS of $0.32 for the Quarter Ended June 30, 2009 3Mylan Reports Adjusted Diluted EPS of $0.32 for the Quarter Ended June 30, 2009 4Mylan Reports Adjusted Diluted EPS of $0.32 for the Quarter Ended June 30, 2009 5Mylan Reports Adjusted Diluted EPS of $0.32 for the Quarter Ended June 30, 2009 6Mylan Reports Adjusted Diluted EPS of $0.32 for the Quarter Ended June 30, 2009 7Mylan Reports Adjusted Diluted EPS of $0.32 for the Quarter Ended June 30, 2009 8Mylan Reports Adjusted Diluted EPS of $0.32 for the Quarter Ended June 30, 2009 9Mylan Reports Adjusted Diluted EPS of $0.32 for the Quarter Ended June 30, 2009 10Mylan Reports Adjusted Diluted EPS of $0.32 for the Quarter Ended June 30, 2009 11Mylan Reports Adjusted Diluted EPS of $0.32 for the Quarter Ended June 30, 2009 12Mylan Reports Adjusted Diluted EPS of $0.32 for the Quarter Ended June 30, 2009 13Mylan Reports Adjusted Diluted EPS of $0.32 for the Quarter Ended June 30, 2009 14Mylan Reports Adjusted Diluted EPS of $0.32 for the Quarter Ended June 30, 2009 15Mylan Reports Adjusted Diluted EPS of $0.32 for the Quarter Ended June 30, 2009 16Mylan Reports Adjusted Diluted EPS of $0.32 for the Quarter Ended June 30, 2009 17Mylan Reports Adjusted Diluted EPS of $0.32 for the Quarter Ended June 30, 2009 18First genetically engineered malaria vaccine to enter human trials 2
... 8 micro-bore tubes to 1 outflow ... tips, Rapid (several millisecond) solution change ... prevention , Solid construction 360, 250 ... For mounting on any micromanipulator Available ...
... (BTI-TN-5B1-4) derived from Trichoplusia ni egg ... be capable of expressing significantly higher ... to other insect cells. High Five ... time as adherent cultures- Quick adaptation into ...
... Racks are ideal for storage and transport ... polypropylene racks withstand extreme temperatures, making them ... may also be autoclaved for use in ... side accommodates 0.5ml microcentrifuge tubes, the other ...
... Signet offers the most comprehensive, ... requirements. We have incorporated unprecedented quality ... capabilities. This includes proven detection chemistries ... to the TechMate protocol. It also ...
Biology Products: