( or determining gene function -- does no...)Gene keeps neural cells on correct developmental path

or determining gene function -- does not work for REST because mice lacking the gene die before they are born. Embryonic stem cells provided a way for Mandel to get around this problem. Unexpectedly, they also revealed fundamental ways in which stem cells remain plastic.

"This paper is like a whole story, beginning with the birth of a neuron and ending with the death of REST," Mandel said.

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Source:Howard Hughes Medical Institute


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