Navigation Links
Gene increases risk of tuberculosis

A study in the December 19 issue of The Journal of Experimental Medicine identifies a small genetic change that increases the odds of developing active tuberculosis (TB). Pedro Flores-Villanueva and his colleagues at the University of Texas Health Center (Tyler, TX) studied groups of patients in Mexico and Korea and found that individuals who carry this genetic change were more likely to develop disease when infected with TB-causing bacteria.

Infections with Mycobacterium tuberculosis, the bacterium that causes TB, are on the rise, with an estimated eight million new infections and two million TB-induced deaths occurring annually. But not all people who are exposed to this bug become ill -- a phenomenon largely explained by genetic differences that make some individuals more prone to developing disease than others. Indeed, a recent scientific study found that a particular region on the human chromosome 17 was associated with increased risk of developing active tuberculosis, but the exact gene(s) responsible for this effect was not identified.

Flores-Villanueva and colleagues show that the culprit behind the increased susceptibility to TB was a small change in the gene that encodes a protein called MCP-1 (the MCP-1 gene resides of chromosome 17). The genetic change was a tiny one, with the DNA sequence differing by only a single nucleotide (the building blocks of DNA). This change, which resulted in increased production of the MCP-1 protein, was five times more prevalent in individuals with active TB than in those who were infected but remained healthy.

MCP-1 is a protein that helps attract immune cells to sites of infection. For this reason, this protein is important during the early immune response to TB-causing bacteria. But extremely high levels of MCP-1 can be dangerous, as they inhibit the production of another immune protein called interleukin-12. Interleukin-12 is required to activate the immune cells that fight off the infectio n once they arrive on the scene. In an accompanying commentary article, geneticists Alexandre Alcais, Jean-Laurent Casanova and their colleagues at the University of Paris note that this is the largest genetic impact on adult TB that has ever been described.


'"/>

Source:Journal of Experimental Medicine


Related biology news :

1. Sexual cooperation: Mating increases longevity in ant queens
2. Global warming increases oyster sensitivity to pollution
3. Prenatal exposure to famine increases risk of schizophrenia
4. Male rivalry increases when females at most fertile, say researchers
5. Lack of a key enzyme dramatically increases resistance to sepsis
6. Variation in bitter-taste receptor gene increases risk for alcoholism
7. Gene variation increases SIDS risk in African Americans
8. Single cell amoeba increases MRSA numbers 1000- fold
9. Mosquito spray increases toxicity of pyrethroids in creek, study finds
10. Tropical forest CO2 emissions tied to nutrient increases
11. Pak1 expression increases tamoxifen resistance in breast cancer patients
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/5/2017)... , April 5, 2017  The Allen Institute for ... Cell Explorer: a one-of-a-kind portal and dynamic digital window ... imaging data, the first application of deep learning to ... stem cell lines and a growing suite of powerful ... for these and future publicly available resources created and ...
(Date:4/3/2017)... , April 3, 2017  Data ... precision engineering platform, detected a statistically significant ... product prior to treatment and objective response ... the potential to predict whether cancer patients ... to treatment, as well as to improve ...
(Date:3/29/2017)... , March 29, 2017  higi, the health IT ... North America , today announced a ... the acquisition of EveryMove. The new investment and acquisition ... of tools to transform population health activities through the ... data. higi collects and secures data today ...
Breaking Biology News(10 mins):
(Date:10/11/2017)... ... 2017 , ... Personal eye wash is a basic first aid supply for any work environment, ... eye do you rinse first if a dangerous substance enters both eyes? It’s one less ... with its unique dual eye piece. , “Whether its dirt and debris, or an acid ...
(Date:10/11/2017)... ... October 11, 2017 , ... Disappearing forests and increased emissions are the main ... people each year. Especially those living in larger cities are affected by air pollution ... of the most pollution-affected countries globally - decided to take action. , “I knew ...
(Date:10/10/2017)... ... October 10, 2017 , ... For the second time ... US2020 STEM Mentoring Award. Representatives of the FirstHand program travelled to Washington, D.C. ... US2020. , US2020’s mission is to change the trajectory of STEM education in ...
(Date:10/10/2017)... , ... October 10, 2017 , ... ... of 13 prestigious awards honoring scientists who have made outstanding ... a scheduled symposium during Pittcon 2018, the world’s leading conference and exposition for ...
Breaking Biology Technology: