Navigation Links
Gene increases risk of tuberculosis

A study in the December 19 issue of The Journal of Experimental Medicine identifies a small genetic change that increases the odds of developing active tuberculosis (TB). Pedro Flores-Villanueva and his colleagues at the University of Texas Health Center (Tyler, TX) studied groups of patients in Mexico and Korea and found that individuals who carry this genetic change were more likely to develop disease when infected with TB-causing bacteria.

Infections with Mycobacterium tuberculosis, the bacterium that causes TB, are on the rise, with an estimated eight million new infections and two million TB-induced deaths occurring annually. But not all people who are exposed to this bug become ill -- a phenomenon largely explained by genetic differences that make some individuals more prone to developing disease than others. Indeed, a recent scientific study found that a particular region on the human chromosome 17 was associated with increased risk of developing active tuberculosis, but the exact gene(s) responsible for this effect was not identified.

Flores-Villanueva and colleagues show that the culprit behind the increased susceptibility to TB was a small change in the gene that encodes a protein called MCP-1 (the MCP-1 gene resides of chromosome 17). The genetic change was a tiny one, with the DNA sequence differing by only a single nucleotide (the building blocks of DNA). This change, which resulted in increased production of the MCP-1 protein, was five times more prevalent in individuals with active TB than in those who were infected but remained healthy.

MCP-1 is a protein that helps attract immune cells to sites of infection. For this reason, this protein is important during the early immune response to TB-causing bacteria. But extremely high levels of MCP-1 can be dangerous, as they inhibit the production of another immune protein called interleukin-12. Interleukin-12 is required to activate the immune cells that fight off the infectio n once they arrive on the scene. In an accompanying commentary article, geneticists Alexandre Alcais, Jean-Laurent Casanova and their colleagues at the University of Paris note that this is the largest genetic impact on adult TB that has ever been described.


'"/>

Source:Journal of Experimental Medicine


Related biology news :

1. Sexual cooperation: Mating increases longevity in ant queens
2. Global warming increases oyster sensitivity to pollution
3. Prenatal exposure to famine increases risk of schizophrenia
4. Male rivalry increases when females at most fertile, say researchers
5. Lack of a key enzyme dramatically increases resistance to sepsis
6. Variation in bitter-taste receptor gene increases risk for alcoholism
7. Gene variation increases SIDS risk in African Americans
8. Single cell amoeba increases MRSA numbers 1000- fold
9. Mosquito spray increases toxicity of pyrethroids in creek, study finds
10. Tropical forest CO2 emissions tied to nutrient increases
11. Pak1 expression increases tamoxifen resistance in breast cancer patients
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/23/2016)... WAKEFIELD, Massachusetts , March 23, 2016 ... kombiniert im Interesse erhöhter Sicherheit Gesichts- und ... Xura, Inc. (NASDAQ: MESG ... heute bekannt, dass das Unternehmen mit SpeechPro ... insbesondere aus der Finanzdienstleistungsbranche, wird die Möglichkeit ...
(Date:3/21/2016)... Unique technology combines v ... security   Xura, Inc. ... digital communications services, today announced it is working alongside ... customers, particularly those in the Financial Services Sector, the ... within a mobile app, alongside, and in combination with, ...
(Date:3/15/2016)... --> --> ... Research "Digital Door Lock Systems Market - Global Industry Analysis, ... global digital door lock systems market in terms of revenue ... forecast to grow at a CAGR of 31.8% during the ... enterprises (MSMEs) across the world and high industrial activity driving ...
Breaking Biology News(10 mins):
(Date:5/4/2016)... York, NY (PRWEB) , ... May 04, 2016 ... ... has leveraged recent innovations in biotechnology to help treat hormonal and stress related ... loss, Nutrafol® has captured the hearts of key opinion leaders in the medical ...
(Date:5/3/2016)... Boston, MA (PRWEB) , ... May 03, 2016 , ... ... ranked number 25 out of the state’s 76 fastest-growing private companies; a small percentage ... of Massachusetts, and ranked organizations on the percent change in revenue from 2012 to ...
(Date:5/3/2016)... , ... May 03, 2016 , ... ... accessibility to unique bioresearch materials from laboratories across the globe, today announced the ... to increase the pace of research toward treatment and prevention measures for the ...
(Date:5/3/2016)... , May 3, 2016  Dr. Thomas P. ... in The Woodlands, Texas , now ... percent of treated fat cells in just 25-minutes, leaving ... to 90 percent of Americans report feeling bothered by ... fat reduction procedures are a growing industry. This innovative ...
Breaking Biology Technology: