Navigation Links
Gene increases risk of tuberculosis

A study in the December 19 issue of The Journal of Experimental Medicine identifies a small genetic change that increases the odds of developing active tuberculosis (TB). Pedro Flores-Villanueva and his colleagues at the University of Texas Health Center (Tyler, TX) studied groups of patients in Mexico and Korea and found that individuals who carry this genetic change were more likely to develop disease when infected with TB-causing bacteria.

Infections with Mycobacterium tuberculosis, the bacterium that causes TB, are on the rise, with an estimated eight million new infections and two million TB-induced deaths occurring annually. But not all people who are exposed to this bug become ill -- a phenomenon largely explained by genetic differences that make some individuals more prone to developing disease than others. Indeed, a recent scientific study found that a particular region on the human chromosome 17 was associated with increased risk of developing active tuberculosis, but the exact gene(s) responsible for this effect was not identified.

Flores-Villanueva and colleagues show that the culprit behind the increased susceptibility to TB was a small change in the gene that encodes a protein called MCP-1 (the MCP-1 gene resides of chromosome 17). The genetic change was a tiny one, with the DNA sequence differing by only a single nucleotide (the building blocks of DNA). This change, which resulted in increased production of the MCP-1 protein, was five times more prevalent in individuals with active TB than in those who were infected but remained healthy.

MCP-1 is a protein that helps attract immune cells to sites of infection. For this reason, this protein is important during the early immune response to TB-causing bacteria. But extremely high levels of MCP-1 can be dangerous, as they inhibit the production of another immune protein called interleukin-12. Interleukin-12 is required to activate the immune cells that fight off the infectio
'"/>

Source:Journal of Experimental Medicine


Page: 1 2

Related biology news :

1. Sexual cooperation: Mating increases longevity in ant queens
2. Global warming increases oyster sensitivity to pollution
3. Prenatal exposure to famine increases risk of schizophrenia
4. Male rivalry increases when females at most fertile, say researchers
5. Lack of a key enzyme dramatically increases resistance to sepsis
6. Variation in bitter-taste receptor gene increases risk for alcoholism
7. Gene variation increases SIDS risk in African Americans
8. Single cell amoeba increases MRSA numbers 1000- fold
9. Mosquito spray increases toxicity of pyrethroids in creek, study finds
10. Tropical forest CO2 emissions tied to nutrient increases
11. Pak1 expression increases tamoxifen resistance in breast cancer patients
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Gene increases risk tuberculosis

(Date:8/29/2014)... - In a cell,s nucleus, chromosomal DNA is ... an amalgam biologists call chromatin. Until about two ... "sidekick," the mere packing material around which the ... have developed a greater appreciation for how DNA/histone ... from multiple research institutions studying the sequence of ...
(Date:8/28/2014)... Yale University researchers have identified a handful of bacterial ... as Crohn,s disease and ulcerative colitis, using patients, own ... are published Aug. 28 in the journal Cell ... intestinal microbiota, which plays a critical role in the ... only a small number of bacterial species affect a ...
(Date:8/28/2014)... Mayo Clinic researcher and his collaborators have developed an ... the process of re-engineering cells for biomedical investigation. CellNet ... methods to aid stem cell engineering. Details of CellNet ... in two back-to-back papers in the journal Cell ... of uses for all types of cell-based investigations and ...
Breaking Biology News(10 mins):'K-to-M' histone mutations: How repressing the repressors may drive tissue-specific cancers 2'K-to-M' histone mutations: How repressing the repressors may drive tissue-specific cancers 3Yale study identifies possible bacterial drivers of IBD 2New tool aids stem cell engineering for medical research 2
... Aware, Inc., a leading provider of ... Dr. DSL® Line Diagnostics Platform (LDP) supports the new ... DSL subscriber lines. The recently ratified standard defines ... (MELT) line testing parameters and reference models. Aware,s ...
... announce 7.5 million of funding for a series of projects ... H1N1 2009 or ,swine flu,. The research will look ... pig and human populations, and in hospital intensive care units. ... reported in Mexico in March this year. In June, as ...
... expected for the number of weeks of pregnancy, due to ... severe as brain damage can result. The condition, known ... to track a baby,s health and determine the best time ... obstetricians have had to rely on educated guesses about the ...
Cached Biology News:Aware, Inc. Announces Support for New ITU Testing Standard with Line Diagnostics Platform 2Aware, Inc. Announces Support for New ITU Testing Standard with Line Diagnostics Platform 3Aware, Inc. Announces Support for New ITU Testing Standard with Line Diagnostics Platform 4£7.5 million ($12.6 million) collaborations lead UK research community's response to H1N1 pandemic 2£7.5 million ($12.6 million) collaborations lead UK research community's response to H1N1 pandemic 3£7.5 million ($12.6 million) collaborations lead UK research community's response to H1N1 pandemic 4Healthy babies by the numbers 2
(Date:8/28/2014)... (PRWEB) August 28, 2014 A ... around the world is available from Strategic Consulting, ... companies. “ Industrial Microbiology Market Review, Fourth Edition: ... Market ” (IMMR—4) tracks and compares microbiology test ... North America, Europe and Asia, and forecasts future ...
(Date:8/28/2014)... NY (PRWEB) August 28, 2014 Whitehouse ... its long term partnership with PTI Inspection Systems ... clients with state of the art leak testing method ... the art instruments currently available. As part of this ... High Voltage Leak Detection Instrument developed and ...
(Date:8/27/2014)... In 2013, Lawrence Livermore National ... Security LLC (LLNS), was awarded more than ... laser system for the European Union's Extreme Light ... the Czech Republic. , When commissioned to its ... " High repetition-rate Advanced Petawatt Laser System " ...
(Date:8/27/2014)... The Global and China Trifluoroacetic Acid ... current state of the Trifluoroacetic Acid industry in Global ... of the industry, including definitions, applications and industry chain ... are provided with a focus on history, developments, trends ... the international and Chinese situation is also offered. , ...
Breaking Biology Technology:2 Billion Industrial Microbiology Tests Conducted for Product Quality and Safety Worldwide 22 Billion Industrial Microbiology Tests Conducted for Product Quality and Safety Worldwide 3Whitehouse Labs Renews Partnership with PTI Inspection Systems 2Whitehouse Labs Renews Partnership with PTI Inspection Systems 3LLNL Synchs up with ELI Beamlines on Timing System 2LLNL Synchs up with ELI Beamlines on Timing System 3Trifluoroacetic Acid Industry (Asia, Europe, North America, ROW) Analysis Report Now Available at ReportsnReports.com 2
... lattice with a honeycomb structure, has great potential for ... But applications have been stymied because the semi-metallic graphene, ... effectively as a semiconductor to amplify or switch electronic ... nanoscale ribbons can open up a larger band gap ...
... ... ... ... ...
... have made a breakthrough in an 80-year-old quandary in ... new materials that could make electronic devices smaller and ... first proposed by physicists in the 1920s, the researchers ... a new material before it,s been created. The new ...
Cached Biology Technology:New graphene 'nanomesh' could change the future of electronics 2Creating a Better Health Ecosystem Focus of Presentation by Alere's Dr. Gordon Norman at Population Health & Disease Management Colloquium 2Creating a Better Health Ecosystem Focus of Presentation by Alere's Dr. Gordon Norman at Population Health & Disease Management Colloquium 3Creating a Better Health Ecosystem Focus of Presentation by Alere's Dr. Gordon Norman at Population Health & Disease Management Colloquium 4Creating a Better Health Ecosystem Focus of Presentation by Alere's Dr. Gordon Norman at Population Health & Disease Management Colloquium 5Princeton scientists find an equation for materials innovation 2Princeton scientists find an equation for materials innovation 3Princeton scientists find an equation for materials innovation 4
12 breakable polypropylene strips of 8 wells each held in a rigid frame. Ideal for antibody assays....
... Features A direct, ... molecules to the well surface ... , Maleic anhydride maintains its ... for months under dry, room ...
... a bovine protein-free alternative to StabilCoat Immunoassay ... that contains non-toxic chemicals in a PBS ... 7.2, and does not contain a preservative. ... antibodies and other biomolecules that are absorbed ...
... stabilizer is designed for stabilizing the ... antibodies for immunoassay development. It ... the coating and drying process and ... can also works as a blocking ...
Biology Products: