Navigation Links
Gene expression becomes heterogeneous with age in humans and rats

In a study of the effects of aging on gene expression, researchers have found that variation in gene expression among individuals tends to increase with age. The findings, which impact our understanding of the molecular forces that govern age-related changes, are reported in the May 23rd issue of Current Biology by Mehmet Somel and colleagues at the Max Planck Institute for Evolutionary Anthropology and the University of Cambridge.

One long-standing observation concerning the physiological decline that accompanies aging is its variability--some people age better than others. However, there has thus far been little or no evidence supporting the existence of similar heterogeneity at the level of gene expression. Lack of such evidence, in turn, gives support to a "programmed aging" hypothesis and argues against the more commonly accepted "stochastic aging" model, in which random biological events play an important role.

In the new work, researchers put to the test the question of whether gene-expression heterogeneity increases with age. Using a wide range of expression data from both humans and rats, the researchers showed that levels of gene expression become more variable with age. Furthermore, they found that the tendency toward increased variation is not restricted to a specific set of genes, implying that increased heterogeneity is the outcome of random processes such as genetic mutation.

These observations corroborate the notion that aging is underpinned by stochastic events. That said, the authors of the study point out that the observed increases in expression variation are surprisingly small, leaving plenty of room for further explanations regarding the relationship between aging-related changes at the organismal level and the underlying molecular mechanisms of aging. Nevertheless, the new results show that with the increasing amounts of molecular data available to researchers, scientists will now experience improved opportunities to a nswer age-old questions about the nature of aging.


'"/>

Source:Cell Press


Related biology news :

1. Alcohols effects on gene expression in the central nervous system
2. Carnegie Mellon scientists develop tool that uses MRI to visualize gene expression in living animals
3. Towards precise classification of cancers based on robust gene functional expression profiles
4. Expression Project for Oncology (expO) completes first phase of standardized gene expression analyses
5. Study: homemade gene expression technology unreliable
6. Cooperation is key—a new way of looking at MicroRNA and how it controls gene expression
7. Agilent Technologies releases probe sequence, annotation information for all its commercial gene expression microarrays
8. Multiple-drug resistant gene expression pattern predicts treatment outcome for pediatric leukemia
9. Computational verification of protein-protein interactions by orthologous co-expression
10. Random gene expression may drive HIV into hiding
11. Confirmation of human protein interaction data by human expression data
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/29/2016)... BOCA RATON, Florida , March 29, 2016 /PRNewswire/ ... ("LegacyXChange" or the "Company") LegacyXChange "LEGX" and SelectaDNA/CSI Protect ... Synthetic DNA in ink used in a variety of ... preventing theft. Buyers of originally created collectibles from athletes ... authenticity through forensic analysis of the DNA. ...
(Date:3/22/2016)... India , March 22, 2016 /PRNewswire/ ... market research report "Electronic Sensors Market for Consumer ... Proximity, & Others), Application (Communication & IT, ... Geography - Global Forecast to 2022", published ... industry is expected to reach USD 26.76 ...
(Date:3/21/2016)... Unique technology combines v ... security   Xura, Inc. ... digital communications services, today announced it is working alongside ... customers, particularly those in the Financial Services Sector, the ... within a mobile app, alongside, and in combination with, ...
Breaking Biology News(10 mins):
(Date:6/27/2016)... ... June 27, 2016 , ... Rolf K. Hoffmann, former ... of the University of North Carolina Kenan-Flagler Business School effective June ... UNC Kenan-Flagler, with a focus on the school’s international efforts, leading classes and ...
(Date:6/24/2016)... ... 2016 , ... While the majority of commercial spectrophotometers and fluorometers use the ... models are higher end machines that use the more unconventional z-dimension of 20mm. ... the bottom of the cuvette holder. , FireflySci has developed several Agilent flow ...
(Date:6/23/2016)... /PRNewswire/ - FACIT has announced the creation of ... company, Propellon Therapeutics Inc. ("Propellon" or "the Company"), ... portfolio of first-in-class WDR5 inhibitors for the treatment ... represent an exciting class of therapies, possessing the ... cancer patients. Substantial advances have been achieved with ...
(Date:6/23/2016)... NEW YORK , June, 23, 2016  The ... students to envision new ways to harness living systems ... of Modern Art (MoMA) in New York ... more than 130 participating students, showcased projects at MoMA,s ... included Paola Antonelli , MoMA,s senior curator of ...
Breaking Biology Technology: