Navigation Links
Gene elevating breast cancer risk also causes prostate cancer

male breast cancer patients, 188 familial and 288 unselected colorectal cancers, as well as 164 familial and 475 unselected prostate cancer patients. In prostate cancer, one multigenerational cancer family was found where cancer occurred in several generations and all patients showed the single mutation in PALB2 that was studied. According to Winqvist, this suggests that this Finnish founder mutation may be important in heritable prostate cancer as well. Male breast cancer and colorectal cancer cases did not display the mutation.

The constitutional mutation elevates the risk of breast cancer four-fold

"Present results show that the discovered PALB2 mutation elevates the risk of breast cancer four-fold. However, we still need more research to better assess the effect on cancer development. As the comprehensive mutation analysis was originally conducted on only 113 cancer families, it may be that there still are other PALB2 genetic defects accounting for heritable breast and prostate cancer susceptibility. Recent results also imply that PALB2 might be a cancer susceptibility gene in other populations as well. It's been shown that two of the mutations identified in Fanconi anemia patients in non-Finnish populations seem to be associated with familial breast cancer," says Winqvist.

Winqvist points out that, in spite of recent advances, known factors can only explain a fraction of heritable susceptibility to breast cancer. He is nonetheless disposed to believe that the evaluation of yet other biologically significant factors will in time improve the situation. "Hopefully, increased knowledge of underlying mechanisms will provide better conditions for cancer prevention, diagnostics and treatment," Winqvist says.


'"/>

Source:Academy of Finland


Page: 1 2

Related biology news :

1. Ritalin packs punch by elevating norepinephrine, suppressing nerve signal transmissions
2. Viral DNA sequence a possible trigger for breast cancer
3. Used in a new way, RNA interference permanently silences key breast cancer gene
4. Biomarkers isolated from saliva successfully predict oral and breast cancer
5. Study reveals dramatic difference between breast cancers in US and Africa
6. Compounds in plastic packaging act as environmental estrogens altering breast genes
7. Alcohol consumption disrupts breastfeeding hormones
8. VCU Massey Cancer Center study shows enzyme linked to spread of breast cancer cells
9. Scientists discover genetic pathway responsible for breast cancer cell growth
10. Study hints at role of stem cell genes in testicular, breast cancers
11. Microarray technology for tailoring breast cancer therapy
Post Your Comments:
(Date:8/20/2008)...netic code of a simple saltwater creature could he...s function in humans and other species. , A stud...ks down the genetic code of Trichoplax , a simple...n the world, even in the common household aquarium...x , genes that are also found in other animals - o...
(Date:8/20/2008)...d tide algae, Karenia brevis, costs approximately ...oast of Florida alone. Scientists at the Georgia I...n reduce the levels of the red tide,s toxicity to ...de,s toxicity to other algae as well. If scientist...city of red tide, they could reduce the vast amoun...
(Date:8/20/2008)...ch Institute (NHGRI), part of the National Institu...illion in grants to develop innovative sequencing ...equence a person,s DNA as a routine part of biomed...o comprehensively sequence any person,s genome is ... of personalized medicine where healthcare provide...
(Date:8/19/2008)...crease invasion of unwanted species, according to ...ted species can completely overtake the reef and e...sing the diversity of marine organisms on the reef...apid change in the dominant biota on a coral reef ...es. , The findings of the study, published in t...
Breaking Biology News(10 mins):Genome of saltwater creature could aid understanding of gene grouping 2Biologists find diatom to reduce red tide's toxicity 2Biologists find diatom to reduce red tide's toxicity 3NHGRI seeks DNA sequencing technologies fit for routine laboratory and medical use 2NHGRI seeks DNA sequencing technologies fit for routine laboratory and medical use 3NHGRI seeks DNA sequencing technologies fit for routine laboratory and medical use 4NHGRI seeks DNA sequencing technologies fit for routine laboratory and medical use 5Shipwrecks on coral reefs harbor unwanted species 2Journal of Antimicrobial Chemotherapy Paper Supports Additional Role for Cethromycin as Potential Treatment for Infections Caused by Community Associ 2523 1Journal of Antimicrobial Chemotherapy Paper Supports Additional Role for Cethromycin as Potential Treatment for Infections Caused by Community Associ 2523 2Journal of Antimicrobial Chemotherapy Paper Supports Additional Role for Cethromycin as Potential Treatment for Infections Caused by Community Associ 2523 3Journal of Antimicrobial Chemotherapy Paper Supports Additional Role for Cethromycin as Potential Treatment for Infections Caused by Community Associ 2523 4Journal of Antimicrobial Chemotherapy Paper Supports Additional Role for Cethromycin as Potential Treatment for Infections Caused by Community Associ 2523 5Global Challenges Chemistry Solutions debuts with focus on drinking water 3764 1Global Challenges Chemistry Solutions debuts with focus on drinking water 3764 2Was it good for you too 3F 22775 1Was it good for you too 3F 22775 2NIAID creates HIV vaccine discovery branch 22771 1NIAID creates HIV vaccine discovery branch 22771 2
...and the bees. But apparently when it comes to bird...the difference is genetic. Species with differenti...le) get around the fact that males and females get...with a balancing act geneticists call dosage compe...nal of Biology shows that birds are extraordinary,...
...use in agriculture now will we meet the acute wate...over the next 50 years. "With earth,s water, land...ugh food for the future ?but it is probable that t...ll lead to crises in many parts of the world" says...national Water Management Institute. , This is the...
...urological Disorders and Stroke (NINDS) today is l...the nutritional supplement creatine can slow the p...atine is not an approved therapy for PD or any oth...cise performance. The potential benefit of creati...s through a new rapid method for screening potenti...
...include a self-assembly stage in which a powerful ...virus,s preformed shell (the capsid). How it manag... but we know that the DNA passes into the capsid s...d the connector. Scientists have speculated that r...A into the capsid as it turns. , In a new study ...
Other Biology News:Bird sex is something else 2Living with water scarcity -- world must act now 2Living with water scarcity -- world must act now 3Living with water scarcity -- world must act now 4Living with water scarcity -- world must act now 5NIH announces phase III clinical trial of creatine for Parkinson's disease 2NIH announces phase III clinical trial of creatine for Parkinson's disease 3The connector rotation hypothesis? Phage do not pack their DNA by rotation 2
(Date:8/21/2008)... NEW YORK, MUNICH, Germany and AMSTERDAM, Neth...thcare and SpePharm Holding, B.V., the,pan-Europea...d that they,have entered into a euro 10 million re...fund SpePharm,s acquisition of Dantrium(R) for Eur...le Pharmaceuticals. At the same,time, TVM Capital,...
(Date:8/20/2008)... VIENNA, Va., Aug. 20 /PRNewswire-USNewswire/ ...0 ranking of the fastest-growing private companies...T) services provider,MicroTech, ranks No. 285 on ... 2008 Inc. 500 list measures revenue growth from 2...U.S.-based, privately held, independent -,no subsi...
(Date:8/20/2008)... INDIANAPOLIS, Ind., Aug. 20 /PRNewswire-First... announced that it has completed the acquisition,o...n Diego-based,biotechnology company focused on dru...y. The completion of the deal followed today,s Spe...SGX stockholders voted in,favor of the merger agre...
(Date:8/20/2008)... Growth Fueled by Popularity with Seniors and ... Marketing, CAMBRIDGE, Mass., Aug. 20 /PRNewswi...hole Health (SWH), a voluntary health care plan fo...ng private company in the,United States., Part of...rowing,companies, SWH had revenue growth of 31,000...
Breaking Biology Technology:TVM Capital, Signet Healthcare Partners and Paul Capital Healthcare Enter into euro 26 Million Financing of SpePharm 2TVM Capital, Signet Healthcare Partners and Paul Capital Healthcare Enter into euro 26 Million Financing of SpePharm 3TVM Capital, Signet Healthcare Partners and Paul Capital Healthcare Enter into euro 26 Million Financing of SpePharm 4TVM Capital, Signet Healthcare Partners and Paul Capital Healthcare Enter into euro 26 Million Financing of SpePharm 5MicroTech Ranks No. 285 on Inc. Magazine's 2008 List of the 500 Fastest Growing Private Companies in America 2Lilly Announces Completion of SGX Acquisition 2Inc. Magazine Names Senior Whole Health the Number One Fastest-Growing Private Company in US 2Inc. Magazine Names Senior Whole Health the Number One Fastest-Growing Private Company in US 3
..., , , , , ... High fidelity cDNA , for clon... RNA , DDDRT a , RAC...T-PCR , One-Step RT-PCR with , ... , Expand Re- , verse Tran...
...p RT-PCR amplification of up to 3 , kb RNA ...units , Cat. No. 1 732 650 500 units , ..., , , Description , , , .... , The Expand High Fidelity PCR System als...elity buffer, 10x conc., with 15 mM MgCl 2 , ...
...ication of GC-rich targets (up to , 5 kb) f...s , , , , , , , Desc...Taq DNA Polymerase and , Pwo DNA Polymerase...xonuclease) , activity]. , The GC-R... An optimized GC-RICH PCR reaction buffer, 5x co...
..., The Polymerase Chain Reaction invented by... the course of modern life science research by ope...ties to study and understand the crucial role of ,... , , , , Roche Applied Science ...hnology , and the necessity to have a therm...
Other Biology Technology:Suggested applications for reverse transcriptases 2Expand High Fidelity PCR System 2Expand High Fidelity PCR System 3GC-RICH PCR System 2Advantages of Roche Applied Science amplification products 2Advantages of Roche Applied Science amplification products 3
Imject Freund's Complete Adjuvant (FCA)
...tion, the secretion of cytoplasmic granules, is a ...s (e.g. basophils, neutrophils, eosinophils, and m...ory granules contain many proinflammatory mediator...ny proteases (Hallgren, 2001). Tryptase, a tetrame...
... DNA gel stain was developed specifically for redu...e for staining DNA in agarose or acrylamide gels. ...hidium bromide but SYBR Safe stain's detection sen...SYBR Safe stain comes as a premixed solution that ...
...ustom Processing Service enables scientists who do...ation and data analysis software to have their bio... to 16 analytes. Its as easy as 1-2-3 Chose the ...es from the S&S antibody menu. Send your samples ...
Biology Products: