Navigation Links
Gene discovery opens door to tackling disease

Western Australian researchers have discovered a new gene that could lead to breakthroughs in breast and prostate cancer, as well as diabetes.

The gene, called SLIRP, was discovered by a team at the Western Australian Institute for Medical Research's (WAIMR) Laboratory for Cancer Medicine, led by Professor Peter Leedman, in collaboration with Professor Bert O'Malley's team at Baylor College of Medicine in Texas.

"When we baited our hook and went fishing in the breast cancer gene library we came up with SLIRP, much to our surprise, as this gene had not been characterised during the mapping of the human genome," said Professor Leedman.

"What's exciting is that SLIRP has the potential to shut down oestrogen in breast cancer cells and testosterone in prostate cancer cells.

"Most of those cancers depend on the hormones to stay alive, so if we can use SLIRP to block the hormones we may be able to help stop those diseases in their tracks."

Professor Leedman said the discovery could open the door to targeted new treatments for the cancers.

"If we can unravel the mystery of how SLIRP works to turn down the hormone action in cancer cells we could potentially develop so-called 'smart' drugs that zoom in on the gene," he said.

"The benefit is that 'smart' drugs can mean fewer nasty side effects for patients as they target specific genes, not entire areas of the body."

The find could also help researchers create blood tests to diagnose breast and prostate cancer.

"A breakthrough in the techniques available to diagnose breast and prostate cancer would hopefully allow for earlier detection and, importantly, lead to better survival rates," said Professor Leedman.

SLIRP has also been shown to turn down genes involved in energy metabolism.

"With its ability to turn off one of the key regulators of energy metabolism, SLIRP could well lead to progress in tackling diabetes and weight problems," Profes sor Leedman said.

The findings are to be published in the international journal, Molecular Cell, today, Friday, June 9.

Professor Leedman and his team have now applied for a patent on the gene.

Professor Leedman, who is also deputy director of WAIMR, is recognized internationally for his work on hormones. Several funding bodies have contributed to this work, including the National Health and Medical Research Council, the National Breast Cancer Foundation, the Cancer Council of WA and the Royal Perth Hospital Medical Research Foundation.

Breast cancer is the most common cancer in Australian women, and about 2500 women and men die each year from breast and prostate cancer.


'"/>

Source:Research Australia


Related biology news :

1. Protein discovery could unlock the secret to better TB treatment
2. Purdue proves concept of using nano-materials for drug discovery
3. UCSD discovery may help extend life of natural pesticide
4. Leprosy microbes lead scientists to immune discovery
5. Biochemists report discovery of structure of major piece of telomerase; implications for cancer
6. Researchers make surprise discovery that some neurons can transmit three signals at once
7. Important discovery about second most fatal cancer
8. Harmless virus may hold key to more effective HIV drug discovery
9. Fundamental discovery -- Bone fracture
10. Genetic discovery could lead to drought-resistant plants
11. Gene discovery sheds light on causes of rare disease, cancer
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/31/2016)... 31, 2016   ... the "Company") LegacyXChange is excited to release ... soon to be launched online site for trading 100% ... ) will also provide potential shareholders a sense of ... to an industry that is notorious for fraud. The ...
(Date:3/23/2016)... , March 23, 2016 ... erhöhter Sicherheit Gesichts- und Stimmerkennung mit Passwörtern ... (NASDAQ: MESG ), ein führender ... das Unternehmen mit SpeechPro zusammenarbeitet, um erstmals ... Finanzdienstleistungsbranche, wird die Möglichkeit angeboten, im Rahmen ...
(Date:3/21/2016)... March 22, 2016 Unique ... passcodes for superior security   ... provider of secure digital communications services, today announced it ... and offer enterprise customers, particularly those in the Financial ... and voice authentication within a mobile app, alongside, and ...
Breaking Biology News(10 mins):
(Date:6/27/2016)... ... 27, 2016 , ... Cancer experts from Austria, Hungary, Switzerland, ... a new and helpful biomarker for malignant pleural mesothelioma. Surviving Mesothelioma has just ... now. , Biomarkers are components in the blood, tissue or body fluids ...
(Date:6/27/2016)... PHILADELPHIA , June 27, 2016  Liquid ... today announced the funding of a Sponsored Research ... study circulating tumor cells (CTCs) from cancer patients.  ... changes in CTC levels correlate with clinical outcomes ... therapies. These data will then be employed to ...
(Date:6/24/2016)... ... June 24, 2016 , ... While the majority of commercial spectrophotometers and fluorometers ... the 6000i models are higher end machines that use the more unconventional z-dimension of ... beam from the bottom of the cuvette holder. , FireflySci has developed several ...
(Date:6/23/2016)... 23, 2016   Boston Biomedical , an ... designed to target cancer stemness pathways, announced that ... Orphan Drug Designation from the U.S. Food and ... cancer, including gastroesophageal junction (GEJ) cancer. Napabucasin is ... inhibit cancer stemness pathways by targeting STAT3, and ...
Breaking Biology Technology: