Navigation Links
Gene controlling circadian rhythms linked to drug addiction

The gene that regulates the body's main biological clocks also may play a pivotal role in drug addiction, researchers at UT Southwestern Medical Center have found.

The Clock gene not only controls the body's circadian rhythms, including sleep and wakefulness, body temperature, hormone levels, blood pressure and heart activity, it may also be a key regulator of the brain's reward system.

UT Southwestern researchers showed that, in mice, the Clock gene regulates the reward response to cocaine, suggesting that similar actions take place in humans. Findings from the multi-center study are available online in the Proceedings of the National Academy of Sciences.

"We found that the Clock gene is not only involved in regulating sleep/wake cycles, but is also very involved in regulating the rewarding responses to drugs of abuse," said Dr. Colleen A. McClung, assistant instructor of psychiatry at UT Southwestern and the study's lead author. "It does so through its actions on dopamine pathways."

Dopamine is a neurotransmitter associated with the "pleasure system" of the brain, providing feelings of enjoyment from certain activities. Dopamine is released by naturally rewarding experiences such as food, sex and the use of certain drugs.

In the study, mice that lacked the Clock gene were injected with cocaine. Not only did the mice experience problems with their circadian cycles - not sleeping as much and becoming more hyperactive - they also found cocaine more rewarding than control mice, demonstrated by their strong preference for the location where the drug was administered.

In addition, Clock-deficient mice produced more dopamine than control mice did, suggesting that the gene controlling circadian rhythms is a key regulator of the brain's reward system and may influence the addictive properties of drugs such as cocaine.

"We tracked dopamine cells in the mice brains and found that these cells fired more rapidly and showed a pattern called bursting, which leads to an usually large dopamine release," Dr. McClung said. "We also found that more dopamine is produced and released in these mice under normal conditions and particularly after exposure to cocaine."

Dr. Eric Nestler, chairman of psychiatry at UT Southwestern and the study's senior author, said the results suggest there may be a link in disruption of circadian rhythms and the tendency to abuse drugs.

"Most work on Clock has focused on the brain's master pacemaker, located in a brain area called the suprachiasmatic nucleus," said Dr. Nestler. "The novelty of Dr. McClung's findings is the role Clock plays in brain reward pathways. The next step is to examine Clock and related genes in human addicts."

Dr. Donald Cooper, assistant professor of psychiatry at UT Southwestern, also contributed to the study, as did researchers from the University of Crete in Heraklion; the Rosalind Franklin University of Medicine and Science in North Chicago; and the Howard Hughes Medical Institute at Northwestern University.

The study was supported by grants from the National Institute on Drug Abuse, the National Institute of Mental Health and the Onassis Public Benefit Foundation.


'"/>

Source:UTSouthwestern


Related biology news :

1. Scientists find that protein controls aging by controlling insulin
2. Enzyme affects hypertension by controlling salt levels in body
3. Liquid crystals show promise in controlling embryonic stem cells
4. Important gene controlling tree growth and development found
5. Key gene controlling eye lens development identified
6. Electronic chip, interacting with the brain, modifies pathways for controlling movement
7. Edge density key to controlling gypsy moth spread
8. Key gene controlling kidney development found
9. After a time-shift, mixed signals from the circadian clock
10. The circadian clock: Understanding natures timepiece
11. Temperature regulates circadian clock in zebrafish
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/28/2016)... and BANGALORE, India , April ... EdgeVerve Systems, a product subsidiary of Infosys (NYSE: ... today announced a global partnership that will provide ... to use mobile banking and payment services.      ... a key innovation area for financial services, but it also ...
(Date:4/15/2016)... 2016  A new partnership announced today will ... decisions in a fraction of the time it ... high-value life insurance policies to consumers without requiring ... Force Diagnostics, rapid testing (A1C, Cotinine and HIV) ... pressure, weight, pulse, BMI, and activity data) available ...
(Date:3/31/2016)... 31, 2016  Genomics firm Nabsys has completed a ... Barrett Bready , M.D., who returned to the company ... technical leadership team, including Chief Technology Officer, John ... Steve Nurnberg and Vice President of Software and Informatics, ... Dr. Bready served as CEO of Nabsys ...
Breaking Biology News(10 mins):
(Date:6/27/2016)... ... , ... Parallel 6 , the leading software as a service (SaaS) ... Virtual Patient Encounter CONSULT module which enables both audio and video telemedicine communication between ... Using the CONSULT module, patients and physicians can schedule a face to face virtual ...
(Date:6/27/2016)... , ... June 27, 2016 , ... ... for Amgen, will join the faculty of the University of North Carolina ... professor of strategy and entrepreneurship at UNC Kenan-Flagler, with a focus on the ...
(Date:6/27/2016)... BOSTON , June 27, 2016   Ginkgo ... biology to industrial engineering, was today awarded as ... a selection of the world,s most innovative companies. ... at scale for the real world in the ... organism engineers work directly with customers including Fortune ...
(Date:6/24/2016)... 2016 Epic Sciences unveiled a liquid ... to PARP inhibitors by targeting homologous recombination deficiency ... new test has already been incorporated into numerous ... types. Over 230 clinical trials are ... including PARP, ATM, ATR, DNA-PK and WEE-1. Drugs ...
Breaking Biology Technology: