Navigation Links
Gene controlling circadian rhythms linked to drug addiction

The gene that regulates the body's main biological clocks also may play a pivotal role in drug addiction, researchers at UT Southwestern Medical Center have found.

The Clock gene not only controls the body's circadian rhythms, including sleep and wakefulness, body temperature, hormone levels, blood pressure and heart activity, it may also be a key regulator of the brain's reward system.

UT Southwestern researchers showed that, in mice, the Clock gene regulates the reward response to cocaine, suggesting that similar actions take place in humans. Findings from the multi-center study are available online in the Proceedings of the National Academy of Sciences.

"We found that the Clock gene is not only involved in regulating sleep/wake cycles, but is also very involved in regulating the rewarding responses to drugs of abuse," said Dr. Colleen A. McClung, assistant instructor of psychiatry at UT Southwestern and the study's lead author. "It does so through its actions on dopamine pathways."

Dopamine is a neurotransmitter associated with the "pleasure system" of the brain, providing feelings of enjoyment from certain activities. Dopamine is released by naturally rewarding experiences such as food, sex and the use of certain drugs.

In the study, mice that lacked the Clock gene were injected with cocaine. Not only did the mice experience problems with their circadian cycles - not sleeping as much and becoming more hyperactive - they also found cocaine more rewarding than control mice, demonstrated by their strong preference for the location where the drug was administered.

In addition, Clock-deficient mice produced more dopamine than control mice did, suggesting that the gene controlling circadian rhythms is a key regulator of the brain's reward system and may influence the addictive properties of drugs such as cocaine.

"We tracked dopamine cells in the mice brains and found that these cells fired more rapidly and showed
'"/>

Source:UTSouthwestern


Page: 1 2

Related biology news :

1. Scientists find that protein controls aging by controlling insulin
2. Enzyme affects hypertension by controlling salt levels in body
3. Liquid crystals show promise in controlling embryonic stem cells
4. Important gene controlling tree growth and development found
5. Key gene controlling eye lens development identified
6. Electronic chip, interacting with the brain, modifies pathways for controlling movement
7. Edge density key to controlling gypsy moth spread
8. Key gene controlling kidney development found
9. After a time-shift, mixed signals from the circadian clock
10. The circadian clock: Understanding natures timepiece
11. Temperature regulates circadian clock in zebrafish
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Gene controlling circadian rhythms linked drug addiction

(Date:7/10/2014)... of the International Science and Business Belt project in ... led by professor Won Do Heo, have developed a ... remotely control specific receptors by light. They have named ... neuronal differentiation inducement. , The most significant feature of ... activate neuronal functions without the need of other substances. ...
(Date:7/10/2014)... or soap might not be ape friendly, and the situation ... in the Cell Press journal Current Biology on ... already led to the conversion of Southeast Asian forest into ... guidelines are not put in place very soon, researchers say ... Africa will be bad news for great apes there as ...
(Date:7/10/2014)... microbial megacity, teeming with life too small to be ... of bacteria can be found. Now scientists have ... own daily cyclesnot unlike the residents of a bustling ... eat at the same times., What,s more, it,s not ... energy to help them photosynthesize food from inorganic substanceshave ...
Breaking Biology News(10 mins):New optogenetic tool for controlling neuronal signalling by blue light 2Hunger for vegetable oil means trouble for Africa's great apes 2New research finds ocean's most abundant organisms have clear daily cycles 2New research finds ocean's most abundant organisms have clear daily cycles 3
... embryonic stem cell, which has the potential to become any ... of genes, proteins that bind DNA, and molecules that modify ... from MIT and the University of California at San Francisco ... cells into mature heart cells. The study, the first to ...
... A team of researchers that has been working ... within four years of a near-commercial-scale production level., The ... has received a $2 million National Science Foundation grant ... Devarenne, a Texas A&M AgriLife Research biochemist and collaborator ...
... ultrasound waves, MIT engineers have found a way to ... drug delivery more efficient. This technology could pave the ... to the researchers. "This could be used for ... systemic drugs and proteins such as insulin, as ...
Cached Biology News:Probing matters of the heart 2Probing matters of the heart 3Oil from algae closer to reality through studies by unique collaboration of scientists 2Oil from algae closer to reality through studies by unique collaboration of scientists 3Getting (drugs) under your skin 2Getting (drugs) under your skin 3
(Date:7/10/2014)... Los Angeles, CA (PRWEB) July 10, 2014 ... Analytical and Bioanalytical techniques during 18-20 August, 2014 at ... to critically review the recent developments in Analytical & ... across the globe. , Speaking on this occasion, Dr. ... that Analytica Acta conference is a remarkable one ...
(Date:7/10/2014)... 2014  Kainos Capital, a firm specializing in acquiring ... it has acquired the Slim-Fast brand from Unilever. Unilever ... of the transaction were not disclosed. Slim-Fast ... that markets ready-to-drink shakes, powders, bars and snacks to ... and in the United Kingdom ...
(Date:7/10/2014)... University of Adelaide research may help in the fight ... can detect tiny quantities of explosives with the use ... the journal Sensors and Actuators B: Chemical , ... can detect explosives in concentrations as low as 6.3 ... of only a few minutes. , "Traditionally explosives detection ...
(Date:7/10/2014)... Wash. The lithium-ion batteries that power our laptops ... longer on a single charge with the help of ... porous material to replace the graphite traditionally used in ... than 10 times the energy storage capacity of graphite. ... battery electrode was published today in Nature Communications ...
Breaking Biology Technology:A Critical Review of Analytical Techniques for Improved Living Standards 2A Critical Review of Analytical Techniques for Improved Living Standards 3A Critical Review of Analytical Techniques for Improved Living Standards 4Kainos Capital Acquires Slim-Fast From Unilever 2Detecting trace amounts of explosives with light 2Silicon sponge improves lithium-ion battery performance 2Silicon sponge improves lithium-ion battery performance 3
... security and compliance as their top issues, they dont see ... a big secret that few executives know about in most ... goes beyond knowing virus scans and firewalls. Security should be ... not a low-level function. , ,In several semesters of network ...
... and the progress of six regional firms were discussed on ... held at the Wisconsin Athletic Club. , ,Limited partners, portfolio ... in Milwaukee to hear a speech from Mark Hessen, president ... to updates from six firms that Mason Wells invests in. ...
... Care International Inc. announced on Wednesday that the U.S. Federal ... Bone Care have signed a definitive agreement for Genzyme ... at $33.00 per fully diluted share. The transaction ... at a meeting on June 30, and other customary ...
Cached Biology Technology:To find solid security candidates, look beyond tech certificates 2To find solid security candidates, look beyond tech certificates 3To find solid security candidates, look beyond tech certificates 4VC trends, company progress discussed at Mason Wells portfolio meeting 2VC trends, company progress discussed at Mason Wells portfolio meeting 3VC trends, company progress discussed at Mason Wells portfolio meeting 4
... Characteristics:, Antibody Binding: High, 400 ng ... volume) , Binding Interaction: Hydrophobic/Ionic , Performance ... (bottom): Flat , Maximum Well Volume: 360 ... tray ,Features, Special optically clear ...
...
...
... enables early selection of the best ... quantitative data for sensitivity, dynamic range, ... Furthermore quantitative antibody fingerprints can be ... your antibodies., The full-service package includes ...
Biology Products: