Navigation Links
Gene chip technology shows potential for identifying life-threatening blood infection

Right now there's no rapid way to diagnose sepsis, a fast-moving blood infection that is a leading cause of death in hospital intensive care units. The illness unleashes a powerful inflammatory response that can quickly overwhelm the body, causing organ failure and death, often within days.

With a narrow window of opportunity for halting its lethal spread, doctors who suspect sepsis typically rush to prescribe powerful antibiotics, even before laboratory tests can confirm the diagnosis. But this practice invariably leads to the inappropriate treatment of many patients who have life-threatening, uncontrollable inflammation without an underlying infection, a condition also common among ICU patients.

New research now suggests that doctors one day could quickly distinguish sepsis from widespread non-infectious inflammation based on genetic profiles of patients' blood. Testing this method in mice, researchers at Washington University School of Medicine in St. Louis found the profiles could accurately discriminate between the two conditions 94 percent of the time. The molecular profiles measure differences in patterns of gene expression that are unique to sepsis vs. non-infectious inflammation.

"Our findings hold out hope that scientists could develop a simple bedside blood test that would greatly speed the diagnosis of sepsis," says J. Perren Cobb, MD, director of Washington University's Center for Critical Illness and Health Engineering and a surgeon at Barnes-Jewish Hospital. "We could in a few hours determine if a patient had a blood infection and treat them right away."

Such a test could not only be used in intensive care units but also in emergency rooms and other settings where a timely diagnosis of infection is important, adds Cobb, who is also professor of surgery and associate professor of genetics. His team's research was published in the November issue of the Journal of the American College of Surgeons.

"If someon
'"/>

Source:Washington University School of Medicine


Page: 1 2 3 4

Related biology news :

1. Novel technology detects human DNA mutations
2. Novel antiviral technology inhibits RSV infection in mice
3. The BIOS Initiative - open source biotechnology is born
4. Revolutionary nanotechnology illuminates brain cells at work
5. Study: homemade gene expression technology unreliable
6. First technology to remove prions that cause vCJD from blood launched
7. Integration of Agilents MS technology, Proteome Systems software to help scientists in proteomics research
8. Agilent Technologies new genome analysis technology set to accelerate Australia fight against mesothelioma
9. Recombinant DNA technology may enable oral, rather than injectable, delivery of protein drugs
10. First production of human monoclonal antibodies in chicken eggs published in Nature Biotechnology
11. Vietnam war technology could aid elephant conservation
Post Your Comments:
(Date:8/28/2014)... German . ... the help of sophisticated assembly lines. Mobile assembly carriers, on ... of these assembly lines. In the case of a car ... arranged in a precise spatial and chronological sequence, resulting in ... The creation of such an assembly line at molecular level ...
(Date:8/28/2014)... from Washington, Oregon, northern California, and Alaska totaled 515 ... of 2014, an increase of more than 10 percent ... Forest Service,s Pacific Northwest Research Station reported today. During ... 4 percent to 247 million board feet. , The ... than 5 percent to $390 million in the same ...
(Date:8/28/2014)... countries will be fully saturated with pests by the ... to a new study led by the University of ... be found in around half the countries that grow ... current rate, scientists fear that a significant proportion of ... the next 30 years. , Crop pests include fungi, ...
Breaking Biology News(10 mins):Nanoscale assembly line 2Nanoscale assembly line 3West coast log exports up, lumber exports down in second quarter of 2014 2New study charts the global invasion of crop pests 2
... influenza (H5N1), rabies, plague, Bovine Spongiform Encephalopathy (BSE), and ... diseases that have made the leap from animals to ... The University of Nottingham are to lead a project ... monitor emerging and re-emerging infections in wildlife. Sixty ...
... degradation in dryland regions continuing to worsen, the ... scientist-recommended indicators for monitoring and assessing desertification that ... agreement was reached after two weeks of negotiations ... the Ninth Session of the Conference of the ...
... science and technology university has formed a tripartite ... Research (Centre National de la Recherche Scientifique or ... and Thales the French electronics giant and a ... and transportation industries. The alliance known as ...
Cached Biology News:Protecting humans and animals from diseases in wildlife 2Satellite data instrumental in combating desertification 2Satellite data instrumental in combating desertification 3New Singapore-France research alliance to develop state-of-the-art nanotechnologies 2New Singapore-France research alliance to develop state-of-the-art nanotechnologies 3
(Date:8/28/2014)... Calif. , Aug. 28, 2014  Armetheon, ... on developing novel mid- to late-stage cardiovascular drug ... million in its first round of financing. The ... Investments and Hercules Bioventures with participation from investors ... and pharmaceutical executive, Dr. Larry Hsu , ...
(Date:8/28/2014)... A new market research report detailing ... from Strategic Consulting, Inc., the leading information resource ... Review, Fourth Edition: Global Review of Microbiology Testing ... compares microbiology test volumes, market values and methods ... and forecasts future volumes and market values through ...
(Date:8/28/2014)... San Diego, CA (PRWEB) August 28, 2014 ... products, Pipette.com is offering a promotion for ... enables Pipette.com customers to purchase the highest quality ... Centrifuge Tubes are ideal for customers doing chemical, ... benefit lab technicians who are not regularly able ...
(Date:8/27/2014)... 27, 2014 Green & Grow Inc. ... B funding and secured Otter Capital as a significant ... accelerate commercialization of GGI’s Agriplier™ technology, building on recent ... , “Since our first meeting, we have been impressed ... product space,” said Alan Sobba, President and CEO of ...
Breaking Biology Technology:Armetheon Completes $7.0 Million Series A Financing 2Armetheon Completes $7.0 Million Series A Financing 32 Billion Industrial Microbiology Tests Conducted for Product Quality and Safety Worldwide 22 Billion Industrial Microbiology Tests Conducted for Product Quality and Safety Worldwide 3Eppendorf Safe Lock Centrifuge Tube Promotion Now Available at Major Pipette Distributor Pipette.com 2Eppendorf Safe Lock Centrifuge Tube Promotion Now Available at Major Pipette Distributor Pipette.com 3Green & Grow Inc. Secures $6M Series B Funding from Otter Capital 2Green & Grow Inc. Secures $6M Series B Funding from Otter Capital 3
... , , , , ... A New Tool for the Rapid and Efficient Extraction,from Swabs in Research Samples , ... , Swabs are commonly used for sample extraction from a,variety ... procedure, the infectious agents are typically,released into a culture medium or onto a culture plate. ...
... , , ... , Transcriptor Reverse Transcriptase is a new recombinant,reverse ... DNA polymerase activity, unwinding,activity, and, importantly, RNase H activity. , ... , Due to the special recombinant structure of ...
... , , ... , Protector RNase Inhibitor ... of,RNases. , Does not interfere with the performance of enzymes in an ... Inhibitor are needed to protect difficult RNA samples. , Is fully active ...
Cached Biology Technology:S.E.T.S. Swab Extraction Tube System 2Increase the Power and Sensitivity for Your cDNA,Synthesis with the New Transcriptor Reverse Transcriptase 2Increase the Power and Sensitivity for Your cDNA,Synthesis with the New Transcriptor Reverse Transcriptase 3Increase the Power and Sensitivity for Your cDNA,Synthesis with the New Transcriptor Reverse Transcriptase 4Protector RNase Inhibitor Enhance the Protection of,RNA against Degradation 2
... Maxi MB (for aqueous, other low volatility ... systems respond to specific applications of molecular ... concentration of heat-labile samples. The RC systems ... cold traps and a wide selection of ...
... Acid Resistant SpeedVac Model SPD131DDA , Our ... SPD131DDA is designed to handle the rigors and ... slim design, digital display, dual independent timers, an ... chamber and vapor pathway. , , Adjustable ...
...
For absolute protein quantification. 4 peptides in 5 vials x 2 nmol per peptide...
Biology Products: