Navigation Links
Gene Vaccine Protects Mice Against Development Of Her2/neu Breast Cancer

Based on successful animal studies, a novel vaccine that uses immune cells as factories to produce Her2/neu protein may offer a way to treat some human breast cancers, say researchers at The University of Texas M. D. Anderson Cancer Center. [Ed : Her2/neu is a protein often present / surexpressed in breast cancer] Their study, published in the online journal, Breast Cancer Research, on Nov. 29, 2004, showed that the vaccine protected 86 percent of experimental mice against HER2/neu-associated breast cancer, even though the tumors were implanted directly into mice.

“This is an exciting strategy that seems to elicit a complete immunologic response against HER2/neu,?says the study’s lead author, Lawrence Lachman, Ph.D., a professor in the Department of Experimental Therapeutics. “Now that we have gone as far as we can in animal studies, I hope this agent might be tested clinically both to treat HER2/neu breast tumors, and to prevent them from spreading.?Up to one-third of human breast cancers are associated with over-expression of the HER2/neu cell surface receptor protein, which continuously “tells?the cancer cell to grow, this producing an aggressive disease that is difficult to stop. The drug Herceptin treats this kind of breast cancer by “plugging?these receptors with a monoclonal antibody, but this treatment “produces only a passive and transitory immune reaction,?Lachman said. “This vaccine, however, like many that treat microbial infections, appears to create a memory in the immune system that produces a lasting protective response.?The vaccine used in this study is a “viral-vectored?approach, in which a naturally occurring virus is re-engineered to be propagation defective but still able to function as a delivery system for proteins from the cancer cells that are to be targeted by the animal’s immune system. The basis for this new va
'"/>

Source:M.D. Anderson Cancer Center


Page: 1 2 3

Related biology news :

1. FDA Approves Human Hookworm Vaccine for Phase I Safety Trials
2. Live Recombinant Adenovirus Vaccine Technique Explored
3. NIAID Initiates Trial of Experimental Avian Flu Vaccine
4. Study Models Impact Of Anthrax Vaccine
5. New Insights Into HIV Immunity Suggest Alternative Approach to Vaccines
6. Pathogen-Mimicking Vaccine As Strategy For Cancer Therapy
7. EuroVacc 02 HIV Vaccine Trial Begins
8. Active Vaccine Prevents Mice From Developing Prion Disease
9. New Vaccine To Be Used For First Time In Polio Outbreak Response
10. Boosting The BCG Vaccine To Beat Tuberculosis
11. Visceral Leishmaniasis: Successful Vaccine Trial In Dogs
Post Your Comments:
(Date:7/31/2014)... NCT00518336) shows the sustained efficacy, immunogenicity and ... vaccine Cervarix. Women vaccinated with the HPV-16/18 ... nine years, and vaccine efficacy (VE) against ... longest follow-up report for a licensed HPV ... full paper. , HPV and vaccination ...
(Date:7/31/2014)... news release is available in German . ... can take up gases similar to a sponge that ... suited for storing hydrogen or greenhouse gases. However, loading ... Karlsruhe Institute of Technology (KIT) now report in ... cor-rosion of the MOF surface. This can be prevented ...
(Date:7/31/2014)... Since Alexandre Edmond Becquerel first discovered the photovoltaic effect ... harness the power of sunlight for its own purposes. ... 2014 issue of the FASEB Journal ... exploiting the power of sunlight by focusing on a ... conserved throughout evolution. This conservationor persistence over time and ...
Breaking Biology News(10 mins):Sustained efficacy, immunogenicity, and safety for GlaxoSmithKline's HPV vaccine 2Sustained efficacy, immunogenicity, and safety for GlaxoSmithKline's HPV vaccine 3Free pores for molecule transport 2Scientists shine bright new light on how living things capture energy from the sun 2
... asthma has been shown to help reduce the formation ... is implicated in the development of Alzheimer,s disease, according ... The researchers published their findings, "Pharmacologic Blockade of 5-Lipoxygenase,Improves ... in the American Journal of Pathology . ...
... The long tendrils of this woody vine, or liana, ... But kudzu may be no match for the lianas of ... studies show that lianas are overgrowing trees in every instance. ... forest ecosystems. Tropical forests contain more than half of ...
... The Pancreatic Cancer Action Network and the American Association ... and E. Scott Seeley, M.D., Ph.D., the 2011 Pancreatic ... each totaling $600,000 over five years, will be formally ... April 2-6. "Because of the poor prognoses and ...
Cached Biology News:Asthma drug could help control or treat Alzheimer's disease 2Stranglers of the tropics -- and beyond 2Stranglers of the tropics -- and beyond 3Pancreatic Cancer Action Network-AACR Pathway to Leadership Grants awarded to early-career investigators 2Pancreatic Cancer Action Network-AACR Pathway to Leadership Grants awarded to early-career investigators 3Pancreatic Cancer Action Network-AACR Pathway to Leadership Grants awarded to early-career investigators 4
(Date:7/31/2014)... 2014 Rancho BioSciences , the ... Omicsoft’s Array Suite with tranSMART . Scientists ... to send data in tranSMART to Array Suite for ... of tranSMART including the new 1.2 release. Array ... storage for the analysis of high dimensional quantification data, ...
(Date:7/31/2014)... Although RNA-Sequencing is a relatively ... analyses appearing around 2008, RNA-Sequencing has rapidly evolved ... In the last several years, assays have improved ... smaller input amounts, process degraded RNA, and perform ... the bioinformatics side, there have been improvements in ...
(Date:7/31/2014)...   BioLife Solutions , Inc. (NASDAQ: ... proprietary clinical grade hypothermic storage and ... products for cells and tissues, today announced today ... be released on Thursday, August 7, 2014, and that ... webcast at 4:30 p.m. ET that afternoon. Management will ...
(Date:7/31/2014)... (PRWEB) July 31, 2014 The Kidney Cancer ... of its monthly news magazine, Kidney Cancer News. , ... presence on a website maintained by an international news organization. ... immediate increase in viewers.” , This month’s program highlights news ... tumors analyzed in a recent study. Kidney Cancer News ...
Breaking Biology Technology:Rancho BioSciences, in Partnership with Omicsoft, have Integrated Array Suite with tranSMART 2Rancho BioSciences, in Partnership with Omicsoft, have Integrated Array Suite with tranSMART 3The Evolution of RNA-Sequencing, Upcoming Live Webinar August 22 hosted by Xtalks 2BioLife Solutions to Report Financial Results for Second Quarter 2014 and Provide Business Update on August 7, 2014 2
... has become the first Medical College of Wisconsin ... in Washington, D.C. , ,Whelan, a professor of neurology and ... two-year contract at the Center for Technology and National ... country receiving the appointment, he will be spending approximately 40 ...
... Madison, Wis. The Wisconsin ... serve as general director for the WiSys Technology ... , ,Founded in 2000 as a supplementary organization to ... the other 25 UW System campuses by protecting the ...
... Wisconsin Source: Kerry-Edwards 2004, Inc. from Sharon Farmer. In ... a town hall meeting between Senator John Kerry and technology ... testing the waters of the presidential campaign, and I had ... three years away. , ,Six months later, I had the ...
Cached Biology Technology:Medical College of Wisconsin researcher gets national defense appointment 2WiSys new manager plans system-wide research awareness 2John Kerry talks technology 2John Kerry talks technology 3John Kerry talks technology 4
This STAT antibody sampler pack contains 8 monoclonal ,STAT antibodies....
... Synthetic peptide derived from the C terminal ... This peptide sequence is downstream from ... polyclonal Connexin 36 antibody Cat. No. 51-6300. ... Reactivity: Mouse (positive control: mouse Connexin ...
Kanamycin is used for selection of resistant bacteria. C18H36N4O11xH2SO4. Contains 10 mg/ml kanamycin (base) utilizing kanamycin sulfate in 0.85% saline....
Invitrogen's Calcium Phosphate Transfection Kit provides high-quality reagents to enable the introduction of DNA into tissue culture cells via calcium phosphate co-precipitation....
Biology Products: